A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia
The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage...
Gespeichert in:
| Veröffentlicht in: | American journal of medical genetics 2001-04, Vol.105 (3), p.236-238 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 238 |
|---|---|
| container_issue | 3 |
| container_start_page | 236 |
| container_title | American journal of medical genetics |
| container_volume | 105 |
| creator | Murad, I. Kremer, I. Dobrusin, M. Muhaheed, M. Bannoura, I. Müller, D.J. Schulze, T.G. Reshef, A. Blanaru, M. Gathas, S. Tsenter, V. Rietschel, M. Belmaker, R.H. Maier, W. Ebstein, Richard P. |
| description | The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi‐square = 0.00, NS). © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.1260 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70873411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70873411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4530-b5a5e958dbe8cdc369e0abcacd2cc5dd37e9f2f9a48a1e066e85918bdde296433</originalsourceid><addsrcrecordid>eNp1kE9v1DAQxS0EosvCgS-ALCEhcUjrv4l9XK1gSylFgiIOHCzHnrAuSRzsrCB8erLaqJw4jTTze29mHkLPKTmnhLALe9d9P6esJA_QihJdFqpk6iFaESpUUTGtz9CTnO8IoXODPUZnlHLJhaAr9G2DG9uFdipqm8HjPB78hGODxz3g7ZQZ_wwJy8tbtsUZUhxjH3qcwMEwxoSH2E5dTMM-5A7Pg-z24U8c9gn6YJ-iR41tMzxb6hp9efvmdntZXH_cvdturgsnJCdFLa0ELZWvQTnveKmB2NpZ55lz0ntegW5Yo61QlgIpS1BSU1V7D0yXgvM1enXyHVL8eYA8mi5kB21re4iHbCqiKi7mn9fo9Ql0KeacoDFDCp1Nk6HEHJM0xyTNMcmZfbGYHuoO_D9yiW4GXi6Azc62TbK9C_me02q2Od52caJ-hRam_-8zm6sPu2VxcVKEPMLve4VNP0xZ8Uqarzc7oz6R90Je3RjB_wKyH5nj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70873411</pqid></control><display><type>article</type><title>A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Murad, I. ; Kremer, I. ; Dobrusin, M. ; Muhaheed, M. ; Bannoura, I. ; Müller, D.J. ; Schulze, T.G. ; Reshef, A. ; Blanaru, M. ; Gathas, S. ; Tsenter, V. ; Rietschel, M. ; Belmaker, R.H. ; Maier, W. ; Ebstein, Richard P.</creator><creatorcontrib>Murad, I. ; Kremer, I. ; Dobrusin, M. ; Muhaheed, M. ; Bannoura, I. ; Müller, D.J. ; Schulze, T.G. ; Reshef, A. ; Blanaru, M. ; Gathas, S. ; Tsenter, V. ; Rietschel, M. ; Belmaker, R.H. ; Maier, W. ; Ebstein, Richard P.</creatorcontrib><description>The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi‐square = 0.00, NS). © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/ajmg.1260</identifier><identifier>PMID: 11353441</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>5HT2C receptor ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Amino Acid Substitution ; Arabs - genetics ; Biological and medical sciences ; European Continental Ancestry Group - genetics ; Family Health ; Female ; Genetic Testing ; genetics ; Germany ; Heterozygote ; Humans ; Infectious Disease Transmission, Vertical ; Male ; Medical sciences ; Middle Aged ; Mothers ; Nuclear Family ; polymorphism ; Polymorphism, Genetic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Receptor, Serotonin, 5-HT2C ; Receptors, Serotonin - genetics ; Schizophrenia ; Schizophrenia - ethnology ; Schizophrenia - etiology ; Schizophrenia - genetics ; transmission disequilibrium test ; Tropical medicine</subject><ispartof>American journal of medical genetics, 2001-04, Vol.105 (3), p.236-238</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4530-b5a5e958dbe8cdc369e0abcacd2cc5dd37e9f2f9a48a1e066e85918bdde296433</citedby><cites>FETCH-LOGICAL-c4530-b5a5e958dbe8cdc369e0abcacd2cc5dd37e9f2f9a48a1e066e85918bdde296433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=981263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11353441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murad, I.</creatorcontrib><creatorcontrib>Kremer, I.</creatorcontrib><creatorcontrib>Dobrusin, M.</creatorcontrib><creatorcontrib>Muhaheed, M.</creatorcontrib><creatorcontrib>Bannoura, I.</creatorcontrib><creatorcontrib>Müller, D.J.</creatorcontrib><creatorcontrib>Schulze, T.G.</creatorcontrib><creatorcontrib>Reshef, A.</creatorcontrib><creatorcontrib>Blanaru, M.</creatorcontrib><creatorcontrib>Gathas, S.</creatorcontrib><creatorcontrib>Tsenter, V.</creatorcontrib><creatorcontrib>Rietschel, M.</creatorcontrib><creatorcontrib>Belmaker, R.H.</creatorcontrib><creatorcontrib>Maier, W.</creatorcontrib><creatorcontrib>Ebstein, Richard P.</creatorcontrib><title>A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia</title><title>American journal of medical genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi‐square = 0.00, NS). © 2001 Wiley‐Liss, Inc.</description><subject>5HT2C receptor</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Amino Acid Substitution</subject><subject>Arabs - genetics</subject><subject>Biological and medical sciences</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Family Health</subject><subject>Female</subject><subject>Genetic Testing</subject><subject>genetics</subject><subject>Germany</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mothers</subject><subject>Nuclear Family</subject><subject>polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Receptor, Serotonin, 5-HT2C</subject><subject>Receptors, Serotonin - genetics</subject><subject>Schizophrenia</subject><subject>Schizophrenia - ethnology</subject><subject>Schizophrenia - etiology</subject><subject>Schizophrenia - genetics</subject><subject>transmission disequilibrium test</subject><subject>Tropical medicine</subject><issn>0148-7299</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9v1DAQxS0EosvCgS-ALCEhcUjrv4l9XK1gSylFgiIOHCzHnrAuSRzsrCB8erLaqJw4jTTze29mHkLPKTmnhLALe9d9P6esJA_QihJdFqpk6iFaESpUUTGtz9CTnO8IoXODPUZnlHLJhaAr9G2DG9uFdipqm8HjPB78hGODxz3g7ZQZ_wwJy8tbtsUZUhxjH3qcwMEwxoSH2E5dTMM-5A7Pg-z24U8c9gn6YJ-iR41tMzxb6hp9efvmdntZXH_cvdturgsnJCdFLa0ELZWvQTnveKmB2NpZ55lz0ntegW5Yo61QlgIpS1BSU1V7D0yXgvM1enXyHVL8eYA8mi5kB21re4iHbCqiKi7mn9fo9Ql0KeacoDFDCp1Nk6HEHJM0xyTNMcmZfbGYHuoO_D9yiW4GXi6Azc62TbK9C_me02q2Od52caJ-hRam_-8zm6sPu2VxcVKEPMLve4VNP0xZ8Uqarzc7oz6R90Je3RjB_wKyH5nj</recordid><startdate>20010408</startdate><enddate>20010408</enddate><creator>Murad, I.</creator><creator>Kremer, I.</creator><creator>Dobrusin, M.</creator><creator>Muhaheed, M.</creator><creator>Bannoura, I.</creator><creator>Müller, D.J.</creator><creator>Schulze, T.G.</creator><creator>Reshef, A.</creator><creator>Blanaru, M.</creator><creator>Gathas, S.</creator><creator>Tsenter, V.</creator><creator>Rietschel, M.</creator><creator>Belmaker, R.H.</creator><creator>Maier, W.</creator><creator>Ebstein, Richard P.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010408</creationdate><title>A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia</title><author>Murad, I. ; Kremer, I. ; Dobrusin, M. ; Muhaheed, M. ; Bannoura, I. ; Müller, D.J. ; Schulze, T.G. ; Reshef, A. ; Blanaru, M. ; Gathas, S. ; Tsenter, V. ; Rietschel, M. ; Belmaker, R.H. ; Maier, W. ; Ebstein, Richard P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4530-b5a5e958dbe8cdc369e0abcacd2cc5dd37e9f2f9a48a1e066e85918bdde296433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>5HT2C receptor</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Amino Acid Substitution</topic><topic>Arabs - genetics</topic><topic>Biological and medical sciences</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Family Health</topic><topic>Female</topic><topic>Genetic Testing</topic><topic>genetics</topic><topic>Germany</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mothers</topic><topic>Nuclear Family</topic><topic>polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Receptor, Serotonin, 5-HT2C</topic><topic>Receptors, Serotonin - genetics</topic><topic>Schizophrenia</topic><topic>Schizophrenia - ethnology</topic><topic>Schizophrenia - etiology</topic><topic>Schizophrenia - genetics</topic><topic>transmission disequilibrium test</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murad, I.</creatorcontrib><creatorcontrib>Kremer, I.</creatorcontrib><creatorcontrib>Dobrusin, M.</creatorcontrib><creatorcontrib>Muhaheed, M.</creatorcontrib><creatorcontrib>Bannoura, I.</creatorcontrib><creatorcontrib>Müller, D.J.</creatorcontrib><creatorcontrib>Schulze, T.G.</creatorcontrib><creatorcontrib>Reshef, A.</creatorcontrib><creatorcontrib>Blanaru, M.</creatorcontrib><creatorcontrib>Gathas, S.</creatorcontrib><creatorcontrib>Tsenter, V.</creatorcontrib><creatorcontrib>Rietschel, M.</creatorcontrib><creatorcontrib>Belmaker, R.H.</creatorcontrib><creatorcontrib>Maier, W.</creatorcontrib><creatorcontrib>Ebstein, Richard P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murad, I.</au><au>Kremer, I.</au><au>Dobrusin, M.</au><au>Muhaheed, M.</au><au>Bannoura, I.</au><au>Müller, D.J.</au><au>Schulze, T.G.</au><au>Reshef, A.</au><au>Blanaru, M.</au><au>Gathas, S.</au><au>Tsenter, V.</au><au>Rietschel, M.</au><au>Belmaker, R.H.</au><au>Maier, W.</au><au>Ebstein, Richard P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia</atitle><jtitle>American journal of medical genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2001-04-08</date><risdate>2001</risdate><volume>105</volume><issue>3</issue><spage>236</spage><epage>238</epage><pages>236-238</pages><issn>0148-7299</issn><eissn>1096-8628</eissn><coden>AJMGDA</coden><abstract>The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi‐square = 0.00, NS). © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11353441</pmid><doi>10.1002/ajmg.1260</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-7299 |
| ispartof | American journal of medical genetics, 2001-04, Vol.105 (3), p.236-238 |
| issn | 0148-7299 1096-8628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70873411 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 5HT2C receptor Adolescent Adult Adult and adolescent clinical studies Amino Acid Substitution Arabs - genetics Biological and medical sciences European Continental Ancestry Group - genetics Family Health Female Genetic Testing genetics Germany Heterozygote Humans Infectious Disease Transmission, Vertical Male Medical sciences Middle Aged Mothers Nuclear Family polymorphism Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptor, Serotonin, 5-HT2C Receptors, Serotonin - genetics Schizophrenia Schizophrenia - ethnology Schizophrenia - etiology Schizophrenia - genetics transmission disequilibrium test Tropical medicine |
| title | A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T20%3A12%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20family-based%20study%20of%20the%20Cys23Ser%205HT2C%20serotonin%20receptor%20polymorphism%20in%20schizophrenia&rft.jtitle=American%20journal%20of%20medical%20genetics&rft.au=Murad,%20I.&rft.date=2001-04-08&rft.volume=105&rft.issue=3&rft.spage=236&rft.epage=238&rft.pages=236-238&rft.issn=0148-7299&rft.eissn=1096-8628&rft.coden=AJMGDA&rft_id=info:doi/10.1002/ajmg.1260&rft_dat=%3Cproquest_cross%3E70873411%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70873411&rft_id=info:pmid/11353441&rfr_iscdi=true |