Secretagogue response of goblet cells and columnar cells in human colonic crypts

Crypts of Lieberkühn were isolated from human colon, and differential interference contrast microscopy distinguished goblet and columnar cells. Activation with carbachol (CCh, 100 microM) or histamine (10 microM) released contents from goblet granules. Stimulation with prostaglandin E(2) (PGE(2), 5...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2000-01, Vol.278 (1), p.C212-C233
Hauptverfasser:	Halm, D R, Halm, S T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Biological Transport - drug effects Body Fluids - metabolism Carbachol - pharmacology Cell Size Cholecystokinin - pharmacology Cholinergic Agonists - pharmacology Colon - cytology Cytoplasmic Granules - metabolism Dinoprostone - metabolism Goblet Cells - classification Goblet Cells - drug effects Goblet Cells - secretion Histamine - pharmacology Humans Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Mathematics Microscopy, Interference Microtomy - methods Mucus - secretion
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