Platelet count at term pregnancy: a reappraisal of the threshold
Objective: To assess the safety of a new platelet count threshold for the definition of maternal thrombocytopenia late in pregnancy. Methods: A platelet count was performed in 6770 pregnant women late in pregnancy and in 6103 of their newborns as well as in a control group of 287 age-matched nonpreg...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2000, Vol.95 (1), p.29-33 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Boehlen, Françoise Hohlfeld, Patrick Extermann, Philippe Perneger, Thomas V De Moerloose, Philippe |
| description | Objective: To assess the safety of a new platelet count threshold for the definition of maternal thrombocytopenia late in pregnancy.
Methods: A platelet count was performed in 6770 pregnant women late in pregnancy and in 6103 of their newborns as well as in a control group of 287 age-matched nonpregnant healthy women.
Results: The prevalence of maternal thrombocytopenia (platelet count less than 150 × 10
9/L) was 11.6%. The mean platelet counts (248 compared with 213 × 10
9/L) and 2.5th percentile (164 compared with 116 × 10
9/L) were significantly higher in healthy nonpregnant women than in pregnant women. Among thrombocytopenic pregnant women, 621 (79%) had platelet counts between 116 and 149 × 10
9/L; none (0%; 95% confidence interval 0, 0.6) had complications related to thrombocytopenia, and none of their newborns had severe thrombocytopenia (platelet count less than 20 × 10
9/L).
Conclusion: In healthy pregnant women, a platelet count over 115 × 10
9/L late in pregnancy does not require further investigation during pregnancy and may be considered a safe threshold. |
| doi_str_mv | 10.1016/S0029-7844(99)00537-2 |
| format | Article |
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Methods: A platelet count was performed in 6770 pregnant women late in pregnancy and in 6103 of their newborns as well as in a control group of 287 age-matched nonpregnant healthy women.
Results: The prevalence of maternal thrombocytopenia (platelet count less than 150 × 10
9/L) was 11.6%. The mean platelet counts (248 compared with 213 × 10
9/L) and 2.5th percentile (164 compared with 116 × 10
9/L) were significantly higher in healthy nonpregnant women than in pregnant women. Among thrombocytopenic pregnant women, 621 (79%) had platelet counts between 116 and 149 × 10
9/L; none (0%; 95% confidence interval 0, 0.6) had complications related to thrombocytopenia, and none of their newborns had severe thrombocytopenia (platelet count less than 20 × 10
9/L).
Conclusion: In healthy pregnant women, a platelet count over 115 × 10
9/L late in pregnancy does not require further investigation during pregnancy and may be considered a safe threshold.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1016/S0029-7844(99)00537-2</identifier><identifier>PMID: 10636497</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Management. Prenatal diagnosis ; Medical sciences ; Middle Aged ; Platelet Count ; Pregnancy - physiology ; Pregnancy Complications, Hematologic - diagnosis ; Pregnancy. Fetus. Placenta ; Reference Values ; Thrombocytopenia - diagnosis</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2000, Vol.95 (1), p.29-33</ispartof><rights>2000 The American College of Obstetricians and Gynecologists</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4876-30eb48ff41cc972b9e27dee94a9f0015cb6df6da2e41e17102350e766d46ca2a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1446006$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10636497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boehlen, Françoise</creatorcontrib><creatorcontrib>Hohlfeld, Patrick</creatorcontrib><creatorcontrib>Extermann, Philippe</creatorcontrib><creatorcontrib>Perneger, Thomas V</creatorcontrib><creatorcontrib>De Moerloose, Philippe</creatorcontrib><title>Platelet count at term pregnancy: a reappraisal of the threshold</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Objective: To assess the safety of a new platelet count threshold for the definition of maternal thrombocytopenia late in pregnancy.
Methods: A platelet count was performed in 6770 pregnant women late in pregnancy and in 6103 of their newborns as well as in a control group of 287 age-matched nonpregnant healthy women.
Results: The prevalence of maternal thrombocytopenia (platelet count less than 150 × 10
9/L) was 11.6%. The mean platelet counts (248 compared with 213 × 10
9/L) and 2.5th percentile (164 compared with 116 × 10
9/L) were significantly higher in healthy nonpregnant women than in pregnant women. Among thrombocytopenic pregnant women, 621 (79%) had platelet counts between 116 and 149 × 10
9/L; none (0%; 95% confidence interval 0, 0.6) had complications related to thrombocytopenia, and none of their newborns had severe thrombocytopenia (platelet count less than 20 × 10
9/L).
Conclusion: In healthy pregnant women, a platelet count over 115 × 10
9/L late in pregnancy does not require further investigation during pregnancy and may be considered a safe threshold.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet Count</subject><subject>Pregnancy - physiology</subject><subject>Pregnancy Complications, Hematologic - diagnosis</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Reference Values</subject><subject>Thrombocytopenia - diagnosis</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq0K1G6X_oSiHFBVDgF_xY65FFTxUakSSFCpN2vWmbAp3iTYTqv-e7ybVeHGYWTLel7PzEPIKaNvGGXq7XdKuSl1LeW5Ma8prYQu-QFZsFqLkgtx-4wsnpAjchzjHaU5aMQhOWJUCSWNXpD33zwk9JgKN0x9KiAVCcOmGAP-7KF3j-8KKALCOAboIvhiaIu0xlwB43rwzQvyvAUf8WR_LsnNp48_Lr-U118_X11-uC6drLUqBcWVrNtWMueM5iuDXDeIRoJp81iVW6mmVQ1wlAyZZpSLiqJWqpHKAQexJGfzv2MYfk8Yk9100aH30OMwRatprfPaLIPVDLowxBiwtWPoNhAeLaN2q87u1NmtF2uM3amzPOde7htMqw02_6RmVxl4tQcgOvBtyHq6-JeTUtHMLomcsYfBZ5Xxl58eMNg1gk_r3C0zvKIl395YrnL3lGMXcwyzxPsuJ6LrsHfYdAFdss3Q_WeBP6sumZc</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Boehlen, Françoise</creator><creator>Hohlfeld, Patrick</creator><creator>Extermann, Philippe</creator><creator>Perneger, Thomas V</creator><creator>De Moerloose, Philippe</creator><general>Elsevier Inc</general><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>Platelet count at term pregnancy: a reappraisal of the threshold</title><author>Boehlen, Françoise ; Hohlfeld, Patrick ; Extermann, Philippe ; Perneger, Thomas V ; De Moerloose, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4876-30eb48ff41cc972b9e27dee94a9f0015cb6df6da2e41e17102350e766d46ca2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet Count</topic><topic>Pregnancy - physiology</topic><topic>Pregnancy Complications, Hematologic - diagnosis</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Reference Values</topic><topic>Thrombocytopenia - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boehlen, Françoise</creatorcontrib><creatorcontrib>Hohlfeld, Patrick</creatorcontrib><creatorcontrib>Extermann, Philippe</creatorcontrib><creatorcontrib>Perneger, Thomas V</creatorcontrib><creatorcontrib>De Moerloose, Philippe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boehlen, Françoise</au><au>Hohlfeld, Patrick</au><au>Extermann, Philippe</au><au>Perneger, Thomas V</au><au>De Moerloose, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet count at term pregnancy: a reappraisal of the threshold</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2000</date><risdate>2000</risdate><volume>95</volume><issue>1</issue><spage>29</spage><epage>33</epage><pages>29-33</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Objective: To assess the safety of a new platelet count threshold for the definition of maternal thrombocytopenia late in pregnancy.
Methods: A platelet count was performed in 6770 pregnant women late in pregnancy and in 6103 of their newborns as well as in a control group of 287 age-matched nonpregnant healthy women.
Results: The prevalence of maternal thrombocytopenia (platelet count less than 150 × 10
9/L) was 11.6%. The mean platelet counts (248 compared with 213 × 10
9/L) and 2.5th percentile (164 compared with 116 × 10
9/L) were significantly higher in healthy nonpregnant women than in pregnant women. Among thrombocytopenic pregnant women, 621 (79%) had platelet counts between 116 and 149 × 10
9/L; none (0%; 95% confidence interval 0, 0.6) had complications related to thrombocytopenia, and none of their newborns had severe thrombocytopenia (platelet count less than 20 × 10
9/L).
Conclusion: In healthy pregnant women, a platelet count over 115 × 10
9/L late in pregnancy does not require further investigation during pregnancy and may be considered a safe threshold.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10636497</pmid><doi>10.1016/S0029-7844(99)00537-2</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 2000, Vol.95 (1), p.29-33 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Biological and medical sciences Female Gynecology. Andrology. Obstetrics Humans Management. Prenatal diagnosis Medical sciences Middle Aged Platelet Count Pregnancy - physiology Pregnancy Complications, Hematologic - diagnosis Pregnancy. Fetus. Placenta Reference Values Thrombocytopenia - diagnosis |
| title | Platelet count at term pregnancy: a reappraisal of the threshold |
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