Antitumor activity of a novel glyco‐nitric oxide conjugate in ovarian carcinoma

BACKGROUND Several studies have shown that nitric oxide (NO)‐releasing agents can kill tumor cells. Unfortunately, currently available NO delivery molecules do not target tumor cells preferentially. To exploit the overexpression of glucose transport proteins and the high level of glucose transport c...

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Veröffentlicht in:	Cancer 2000-01, Vol.88 (2), p.381-388
Hauptverfasser:	Cantuaria, Guilherme, Magalhaes, Albino, Angioli, Roberto, Mendez, Luis, Mirhashemi, Ramin, Wang, Jianqiang, Wang, Peng, Penalver, Manuel, Averette, Hervy, Braunschweiger, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences carcinoma Drug Screening Assays, Antitumor Female General aspects Glut‐1 Humans Immunohistochemistry Medical sciences Monosaccharide Transport Proteins - biosynthesis nitric oxide Nitric Oxide - chemistry Nitric Oxide - pharmacology Nitric Oxide Donors - chemistry Nitric Oxide Donors - pharmacology Ovarian Neoplasms - pathology Ovary Penicillamine - analogs & derivatives Penicillamine - chemistry Penicillamine - pharmacology Pharmacology. Drug treatments S-Nitroso-N-Acetylpenicillamine S‐nitroso‐N‐acetyl‐penicillamine Tumor Cells, Cultured - drug effects
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