Effects of endothelin-1 and nitric oxide on glucokinase activity in isolated rat hepatocytes

To test the hypothesis that endothelin-1 (ET-1) and nitrice oxide (NO) influence glucokinase (GK) activity in an opposite manner, we evaluated the effects of ET-1, L-NAME, an inhibitor of NO synthase, and l-arginine, a substrate for NO synthase, on GK activity and glycogen content in isolated rat he...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2000, Vol.49 (1), p.73-80
Hauptverfasser:	Monti, L.D., Valsecchi, G., Costa, S., Sandoli, E.P., Phan, C.V., Pontiroli, A.E., Piatti, P.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - pharmacology Biological and medical sciences Cells, Cultured Cyclic GMP - metabolism Endothelin Receptor Antagonists Endothelin-1 - pharmacology Enzyme Inhibitors - pharmacology Enzymes. Coenzymes. Vitamins. Pigments Fundamental and applied biological sciences. Psychology Glucokinase - antagonists & inhibitors Glucokinase - metabolism Glucose - metabolism Glycogen - metabolism Kinetics Liver - enzymology Male Metabolisms and neurohumoral controls NG-Nitroarginine Methyl Ester - pharmacology Nitrates - metabolism Nitric Oxide - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitrites - metabolism Oligopeptides - pharmacology Piperidines - pharmacology Rats Rats, Sprague-Dawley Vertebrates: anatomy and physiology, studies on body, several organs or systems
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