Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease

Prion diseases, or transmissible spongiform encephalopathies, are a relatively rare group of chronic degenerative disorders afflicting both animals and humans, characterized by typical histopathological signs such as amyloid deposition, neuronal loss and spongiform changes. Despite the absence of a...

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Veröffentlicht in:	Glia 2000-02, Vol.29 (4), p.392-396
Hauptverfasser:	Walsh, Desmond T., Perry, V. Hugh, Minghetti, Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences brain macrophages Cyclooxygenase 2 cyclooxygenase II Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Enzyme Induction Female Free Radicals Gliosis - enzymology Hippocampus - enzymology Hippocampus - pathology Immunoenzyme Techniques inflammation Isoenzymes - biosynthesis Isoenzymes - genetics Male Medical sciences Mice Mice, Inbred C57BL Microglia - enzymology Nerve Degeneration neurodegenerative diseases Neurology Prion Diseases - enzymology Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics prostaglandins immunocytochemistry Reactive Oxygen Species
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