Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action

In pancreatic beta-cells, glucose metabolism signals insulin secretion by altering the cellular array of messenger molecules. ATP is particularly important, given its role in regulating cation channel activity, exocytosis, and events dependent upon its hydrolysis. Uncoupling protein (UCP)-2 is propo...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2001-06, Vol.50 (6), p.1302-1310
Hauptverfasser:	CHAN, Catherine B, DE LEO, Domenica, JOSEPH, Jamie W, MCQUAID, Timothy S, XIAO FANG HA, FANG XU, TSUSHIMA, Robert G, PENNEFATHER, Peter S, SALAPATEK, Anne Marie F, WHEELER, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - physiology Animals Biological and medical sciences Dextrose Diabetes Diabetes research Diabetes. Impaired glucose tolerance Dietary Fats - administration & dosage Dietary Fats - pharmacology Electrophysiology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose Glucose - pharmacology Humans Insulin Insulin - metabolism Insulin Secretion Intracellular Membranes - drug effects Intracellular Membranes - physiology Ion Channels Islets of Langerhans - drug effects Islets of Langerhans - metabolism Medical sciences Membrane Transport Proteins Mitochondria - drug effects Mitochondria - physiology Mitochondrial Proteins Physiological aspects Potassium Channels - metabolism Proteins - genetics Proteins - metabolism Rats Reference Values RNA, Messenger - metabolism Rubidium - metabolism Uncoupling Protein 2
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