Immunostimulant oxidized β-glucan conjugates
β-Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many β-Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the β-Glucan from Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore...
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| Veröffentlicht in: | International immunopharmacology 2001-03, Vol.1 (3), p.539-550 |
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| creator | Cross, G.G Jennings, H.J Whitfield, D.M Penney, C.L Zacharie, B Gagnon, L |
| description | β-Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many β-Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the β-Glucan from
Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized β-glucan and its conjugates with
O-β-alanyl-5-[6-(
N,
N′-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells and macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess. |
| doi_str_mv | 10.1016/S1567-5769(00)00021-7 |
| format | Article |
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Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized β-glucan and its conjugates with
O-β-alanyl-5-[6-(
N,
N′-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells and macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/S1567-5769(00)00021-7</identifier><identifier>PMID: 11367537</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adjuvants, Immunologic - chemistry ; Adjuvants, Immunologic - isolation & purification ; Adjuvants, Immunologic - pharmacology ; Animals ; B-Lymphocytes - drug effects ; B-Lymphocytes - immunology ; Biological and medical sciences ; Carbohydrate Sequence ; Cytotoxic T-lymphocytes ; Female ; glucans ; Glucans - chemistry ; Glucans - isolation & purification ; Glucans - pharmacology ; Humans ; Immunomodulators ; Immunostimulant ; In Vitro Techniques ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - immunology ; Macrophages - drug effects ; Macrophages - immunology ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Natural killer cells ; Oxidation ; Oxidation-Reduction ; Pharmacology. Drug treatments ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - chemistry ; T-Lymphocytes, Cytotoxic - drug effects ; T-Lymphocytes, Cytotoxic - immunology ; β-Glucan</subject><ispartof>International immunopharmacology, 2001-03, Vol.1 (3), p.539-550</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-5a320509aa159528aab04ffaeec20a4f651cb0f889a9b451005a7a1796b34bd13</citedby><cites>FETCH-LOGICAL-c420t-5a320509aa159528aab04ffaeec20a4f651cb0f889a9b451005a7a1796b34bd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1567-5769(00)00021-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=988152$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11367537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cross, G.G</creatorcontrib><creatorcontrib>Jennings, H.J</creatorcontrib><creatorcontrib>Whitfield, D.M</creatorcontrib><creatorcontrib>Penney, C.L</creatorcontrib><creatorcontrib>Zacharie, B</creatorcontrib><creatorcontrib>Gagnon, L</creatorcontrib><title>Immunostimulant oxidized β-glucan conjugates</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>β-Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many β-Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the β-Glucan from
Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized β-glucan and its conjugates with
O-β-alanyl-5-[6-(
N,
N′-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells and macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess.</description><subject>Adjuvants, Immunologic - chemistry</subject><subject>Adjuvants, Immunologic - isolation & purification</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Sequence</subject><subject>Cytotoxic T-lymphocytes</subject><subject>Female</subject><subject>glucans</subject><subject>Glucans - chemistry</subject><subject>Glucans - isolation & purification</subject><subject>Glucans - pharmacology</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Immunostimulant</subject><subject>In Vitro Techniques</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - immunology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>Natural killer cells</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology. Drug treatments</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - chemistry</subject><subject>T-Lymphocytes, Cytotoxic - drug effects</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>β-Glucan</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1Kw0AQxxdRbK0-glIQRA_RmSSb3ZxEih-Fggf1vEw2m7IlHzWbiPpYPojPZNpGPfY0w_CbmT8_xo4RLhEwunpCHgmPiyg-B7gAAB89scOGKIX0UADf7fpfZMAOnFsAdPMQ99kAMYgED8SQedOiaMvKNbZocyqbcfVuU_tp0vH3lzfPW03lWFflop1TY9wh28sod-aoryP2cnf7PHnwZo_308nNzNOhD43HKfCBQ0yEPOa-JEogzDIyRvtAYRZx1AlkUsYUJyFHAE6CUMRREoRJisGInW3uLuvqtTWuUYV12uRdQlO1TgmQUez720GUIACk34F8A-q6cq42mVrWtqD6QyGolVC1FqpWthSAWgtVots76R-0SWHS_63eYAec9gA5TXlWU6mt--NiKZGv3l9vKNNZe7OmVk5bU2qT2troRqWV3RLkB4AKkTE</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Cross, G.G</creator><creator>Jennings, H.J</creator><creator>Whitfield, D.M</creator><creator>Penney, C.L</creator><creator>Zacharie, B</creator><creator>Gagnon, L</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Immunostimulant oxidized β-glucan conjugates</title><author>Cross, G.G ; Jennings, H.J ; Whitfield, D.M ; Penney, C.L ; Zacharie, B ; Gagnon, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-5a320509aa159528aab04ffaeec20a4f651cb0f889a9b451005a7a1796b34bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adjuvants, Immunologic - chemistry</topic><topic>Adjuvants, Immunologic - isolation & purification</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Carbohydrate Sequence</topic><topic>Cytotoxic T-lymphocytes</topic><topic>Female</topic><topic>glucans</topic><topic>Glucans - chemistry</topic><topic>Glucans - isolation & purification</topic><topic>Glucans - pharmacology</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>Immunostimulant</topic><topic>In Vitro Techniques</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - immunology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>Natural killer cells</topic><topic>Oxidation</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology. Drug treatments</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - chemistry</topic><topic>T-Lymphocytes, Cytotoxic - drug effects</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>β-Glucan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cross, G.G</creatorcontrib><creatorcontrib>Jennings, H.J</creatorcontrib><creatorcontrib>Whitfield, D.M</creatorcontrib><creatorcontrib>Penney, C.L</creatorcontrib><creatorcontrib>Zacharie, B</creatorcontrib><creatorcontrib>Gagnon, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cross, G.G</au><au>Jennings, H.J</au><au>Whitfield, D.M</au><au>Penney, C.L</au><au>Zacharie, B</au><au>Gagnon, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunostimulant oxidized β-glucan conjugates</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>1</volume><issue>3</issue><spage>539</spage><epage>550</epage><pages>539-550</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>β-Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many β-Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the β-Glucan from
Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized β-glucan and its conjugates with
O-β-alanyl-5-[6-(
N,
N′-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells and macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11367537</pmid><doi>10.1016/S1567-5769(00)00021-7</doi><tpages>12</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - isolation & purification Adjuvants, Immunologic - pharmacology Animals B-Lymphocytes - drug effects B-Lymphocytes - immunology Biological and medical sciences Carbohydrate Sequence Cytotoxic T-lymphocytes Female glucans Glucans - chemistry Glucans - isolation & purification Glucans - pharmacology Humans Immunomodulators Immunostimulant In Vitro Techniques Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Macrophages - drug effects Macrophages - immunology Medical sciences Mice Mice, Inbred C57BL Molecular Sequence Data Natural killer cells Oxidation Oxidation-Reduction Pharmacology. Drug treatments Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology β-Glucan |
| title | Immunostimulant oxidized β-glucan conjugates |
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