Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: A case report and literature review
The association of acanthosis nigricans (AN) with the sign of Leser-Trélat (LT) and gastric carcinoma is rare. Our patient was a 69-year-old man, who presented with hematemesis; a stage IV poorly differentiated, diffuse type, adenocarcinoma of the gastric antrum was diagnosed. The AN was striking, w...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2000-02, Vol.42 (2), p.357-362 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Yeh, James S.M. Munn, Stephanie E. Plunkett, Tim A. Harper, Peter G. Hopster, Deborah J. du Vivier, Anthony W. |
| description | The association of acanthosis nigricans (AN) with the sign of Leser-Trélat (LT) and gastric carcinoma is rare. Our patient was a 69-year-old man, who presented with hematemesis; a stage IV poorly differentiated, diffuse type, adenocarcinoma of the gastric antrum was diagnosed. The AN was striking, with florid cutaneous papillomatosis that also involved the mucous membranes of the mouth and eyelids, and keratoderma. AN and the sign of LT predated tumor detection by 6 months and regressed after chemotherapy in parallel with reduction of the tumor load, demonstrating the dermatoses as paraneoplastic phenomena. The patient died 7 months after completion of chemotherapy. The coexistence of AN and the sign of LT should prompt a search for underlying malignancy. The pathogenesis of both dermatoses is discussed. (J Am Acad Dermatol 2000;42:357-62.) |
| doi_str_mv | 10.1016/S0190-9622(00)90112-9 |
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Our patient was a 69-year-old man, who presented with hematemesis; a stage IV poorly differentiated, diffuse type, adenocarcinoma of the gastric antrum was diagnosed. The AN was striking, with florid cutaneous papillomatosis that also involved the mucous membranes of the mouth and eyelids, and keratoderma. AN and the sign of LT predated tumor detection by 6 months and regressed after chemotherapy in parallel with reduction of the tumor load, demonstrating the dermatoses as paraneoplastic phenomena. The patient died 7 months after completion of chemotherapy. The coexistence of AN and the sign of LT should prompt a search for underlying malignancy. The pathogenesis of both dermatoses is discussed. (J Am Acad Dermatol 2000;42:357-62.)</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/S0190-9622(00)90112-9</identifier><identifier>PMID: 10640933</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Acanthosis Nigricans - diagnosis ; Acanthosis Nigricans - etiology ; Acanthosis Nigricans - pathology ; Adenocarcinoma - complications ; Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Aged ; Biological and medical sciences ; Fatal Outcome ; Gastric Mucosa - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Keratosis, Seborrheic - diagnosis ; Keratosis, Seborrheic - etiology ; Keratosis, Seborrheic - pathology ; Male ; Medical sciences ; Mouth Mucosa - pathology ; Skin - pathology ; Stomach Neoplasms - complications ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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Our patient was a 69-year-old man, who presented with hematemesis; a stage IV poorly differentiated, diffuse type, adenocarcinoma of the gastric antrum was diagnosed. The AN was striking, with florid cutaneous papillomatosis that also involved the mucous membranes of the mouth and eyelids, and keratoderma. AN and the sign of LT predated tumor detection by 6 months and regressed after chemotherapy in parallel with reduction of the tumor load, demonstrating the dermatoses as paraneoplastic phenomena. The patient died 7 months after completion of chemotherapy. The coexistence of AN and the sign of LT should prompt a search for underlying malignancy. The pathogenesis of both dermatoses is discussed. (J Am Acad Dermatol 2000;42:357-62.)</description><subject>Acanthosis Nigricans - diagnosis</subject><subject>Acanthosis Nigricans - etiology</subject><subject>Acanthosis Nigricans - pathology</subject><subject>Adenocarcinoma - complications</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Fatal Outcome</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Keratosis, Seborrheic - diagnosis</subject><subject>Keratosis, Seborrheic - etiology</subject><subject>Keratosis, Seborrheic - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mouth Mucosa - pathology</subject><subject>Skin - pathology</subject><subject>Stomach Neoplasms - complications</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU2O1DAQRi0EYpqBI4C8QAgWgbITxSk2o1GLP6klFgxrq-JUuo3STmO7GTgF5-AcXAxnpoFVydarT_rqCfFYwUsFqn31CRRCha3WzwFeICilK7wjVgrQVK3pzF2x-oeciQcpfQEAbGpzX5wpaBvAul6Jn-uZv_uUOTiW8yjJUci7Ofkkg99GX55JUhhk3rFMfhsWaMOJY3UVf_-aKEsfJMkDZc8hy2ufd3JLKZdVSQOH2VF0Psx7ei0vpaPEMvJhjvkmdfKZI-VjXH6_eb5-KO6NNCV-dJrn4vPbN1fr99Xm47sP68tNxRp1LqVKLRzRtI1B1evOadMpp5BgIOg09l0PrdOq7xvQ6Bo3OOU6NGhoBNXX5-LZbe4hzl-PnLLd--R4mijwfEzWQNciaCjgkxN47Pc82EP0e4o_7N8TFuDpCaDkaBojBefTf053RU1TsItbjEur0jTa5Pxy9cFHdtkOsy-ZdnFrb9zaRZyFMhe3Fus_IhOWzA</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Yeh, James S.M.</creator><creator>Munn, Stephanie E.</creator><creator>Plunkett, Tim A.</creator><creator>Harper, Peter G.</creator><creator>Hopster, Deborah J.</creator><creator>du Vivier, Anthony W.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: A case report and literature review</title><author>Yeh, James S.M. ; Munn, Stephanie E. ; Plunkett, Tim A. ; Harper, Peter G. ; Hopster, Deborah J. ; du Vivier, Anthony W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e292t-969629f9764791b28c2781c19a0da0829b8b06c21bb4029c4cdc1c89797af01b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acanthosis Nigricans - diagnosis</topic><topic>Acanthosis Nigricans - etiology</topic><topic>Acanthosis Nigricans - pathology</topic><topic>Adenocarcinoma - complications</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Fatal Outcome</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Keratosis, Seborrheic - diagnosis</topic><topic>Keratosis, Seborrheic - etiology</topic><topic>Keratosis, Seborrheic - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mouth Mucosa - pathology</topic><topic>Skin - pathology</topic><topic>Stomach Neoplasms - complications</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, James S.M.</creatorcontrib><creatorcontrib>Munn, Stephanie E.</creatorcontrib><creatorcontrib>Plunkett, Tim A.</creatorcontrib><creatorcontrib>Harper, Peter G.</creatorcontrib><creatorcontrib>Hopster, Deborah J.</creatorcontrib><creatorcontrib>du Vivier, Anthony W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, James S.M.</au><au>Munn, Stephanie E.</au><au>Plunkett, Tim A.</au><au>Harper, Peter G.</au><au>Hopster, Deborah J.</au><au>du Vivier, Anthony W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: A case report and literature review</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>42</volume><issue>2</issue><spage>357</spage><epage>362</epage><pages>357-362</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>The association of acanthosis nigricans (AN) with the sign of Leser-Trélat (LT) and gastric carcinoma is rare. Our patient was a 69-year-old man, who presented with hematemesis; a stage IV poorly differentiated, diffuse type, adenocarcinoma of the gastric antrum was diagnosed. The AN was striking, with florid cutaneous papillomatosis that also involved the mucous membranes of the mouth and eyelids, and keratoderma. AN and the sign of LT predated tumor detection by 6 months and regressed after chemotherapy in parallel with reduction of the tumor load, demonstrating the dermatoses as paraneoplastic phenomena. The patient died 7 months after completion of chemotherapy. The coexistence of AN and the sign of LT should prompt a search for underlying malignancy. The pathogenesis of both dermatoses is discussed. (J Am Acad Dermatol 2000;42:357-62.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>10640933</pmid><doi>10.1016/S0190-9622(00)90112-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Acanthosis Nigricans - diagnosis Acanthosis Nigricans - etiology Acanthosis Nigricans - pathology Adenocarcinoma - complications Adenocarcinoma - diagnosis Adenocarcinoma - pathology Aged Biological and medical sciences Fatal Outcome Gastric Mucosa - pathology Gastroenterology. Liver. Pancreas. Abdomen Humans Keratosis, Seborrheic - diagnosis Keratosis, Seborrheic - etiology Keratosis, Seborrheic - pathology Male Medical sciences Mouth Mucosa - pathology Skin - pathology Stomach Neoplasms - complications Stomach Neoplasms - diagnosis Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: A case report and literature review |
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