Physiological modeling of a proposed mechanism of enzyme induction by TCDD

A physiological model was previously constructed to facilitate extrapolation of surrogates for the effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) in rat liver to doses comparable to human environmental exposures. The model included induction of P450 isozymes and suggested the presence of mul...

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Veröffentlicht in:	Toxicology (Amsterdam) 2001-05, Vol.162 (3), p.193-208
Hauptverfasser:	Kohn, Michael C., Walker, Nigel J., Kim, Amy H., Portier, Christopher J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Algorithms Animals Aryl Hydrocarbon Hydroxylases Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases CYP1A1 protein CYP1A2 protein CYP1B1 protein Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 - drug effects Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism cytochrome P450 Dioxins - metabolism Disease Models, Animal Dose-Response Relationship, Drug Enzyme induction Enzyme Induction - drug effects Enzyme Induction - genetics Enzyme Induction - physiology Gene expression kinetics Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene Expression Regulation - physiology Kinetics Liver - drug effects Liver - enzymology Medical sciences PBPK modeling Pharmacodynamics Polychlorinated Dibenzodioxins - administration & dosage Polychlorinated Dibenzodioxins - pharmacokinetics Polychlorinated Dibenzodioxins - pharmacology Rats Receptors, Aryl Hydrocarbon - drug effects Receptors, Aryl Hydrocarbon - metabolism RNA, Messenger - drug effects RNA, Messenger - metabolism TCDD Time Factors Toxicology Various organic compounds
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