Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine a, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days

Transplantation of adult porcine islets (APIs) offers a possible means of treating diabetes. However, isolating APIs has been notoriously difficult. Furthermore, islet xenograft rejection must be prevented. APIs were isolated by a modified automated method. API quality was assessed by static glucose...

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Veröffentlicht in:	Transplantation 2001-04, Vol.71 (8), p.1024-1033
Hauptverfasser:	WENNBERG, Lars, ZHENSUN SONG, BENNET, William, JIANG ZHANG, NAVA, Silvia, SUNDBERG, Bent, BARI, Selina, GUSTAV GROTH, Carl, KORSGREN, Olle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Heterophile - blood Biological and medical sciences Blood Glucose - metabolism C-Peptide - blood Cell Culture Techniques Cell Separation cyclosporin A Cyclosporine - therapeutic use Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - surgery Drug Therapy, Combination Female Graft Survival - drug effects Graft Survival - immunology Immunoglobulin G - blood Immunoglobulin M - blood Immunosuppressive Agents - therapeutic use Islets of Langerhans - cytology Islets of Langerhans Transplantation - immunology Islets of Langerhans Transplantation - pathology Isoxazoles - therapeutic use Leflunomide Liver, biliary tract, pancreas, portal circulation, spleen Macrophages - pathology Medical sciences Mice Mice, Nude mycophenolate mofetil Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - therapeutic use Rats Rats, Inbred Lew Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Swine Transplantation, Heterologous - immunology Transplantation, Heterologous - pathology
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