The Specificity of Receptor Binding by Vascular Endothelial Growth Factor-D Is Different in Mouse and Man

Human vascular endothelial growth factor-D (VEGF-D) binds and activates VEGFR-2 and VEGFR-3, receptors expressed on vascular and lymphatic endothelial cells. As VEGFR-2 signals for angiogenesis and VEGFR-3 is thought to signal for lymphangiogenesis, it was proposed that VEGF-D stimulates growth of b...

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (22), p.19166-19171
Hauptverfasser:	Baldwin, Megan E., Catimel, Bruno, Nice, Edouard C., Roufail, Sally, Hall, Nathan E., Stenvers, Kaye L., Karkkainen, Marika J., Alitalo, Kari, Stacker, Steven A., Achen, Marc G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Biological Assay Biosensing Techniques Blotting, Western Cross-Linking Reagents - pharmacology Electrophoresis, Polyacrylamide Gel Embryo, Mammalian - metabolism Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - metabolism Endothelium, Vascular - metabolism Epidermis - metabolism Humans Immunohistochemistry In Situ Hybridization Kinetics Ligands Mice Models, Molecular Molecular Sequence Data Mutation Protein Binding Protein Conformation Protein Structure, Tertiary Receptor Protein-Tyrosine Kinases - metabolism Receptors, Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor Sequence Homology, Amino Acid Skin - embryology Skin - metabolism Time Factors Vascular Endothelial Growth Factor D Vascular Endothelial Growth Factor Receptor-3
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