Intestinal mucosal immune response in chickens following intraocular immunization with liposome-associated Salmonella enterica serovar enteritidis antigen
Induction of intestinal mucosal immune responses against Salmonella enterica serovar enteritidis was studied by immunizing chickens with liposome-associated antigen. An ultrasonicated whole cell extract of the bacteria was used for immunizing antigen. Intraocular immunization induced serum IgA, IgG...
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| Veröffentlicht in: | Developmental and comparative immunology 2001-06, Vol.25 (5), p.475-484 |
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| creator | Fukutome, Koichi Watarai, Shinobu Mukamoto, Masafumi Kodama, Hiroshi |
| description | Induction of intestinal mucosal immune responses against
Salmonella enterica serovar
enteritidis was studied by immunizing chickens with liposome-associated antigen. An ultrasonicated whole cell extract of the bacteria was used for immunizing antigen. Intraocular immunization induced serum IgA, IgG and IgM responses. Also, significant IgA and IgG antibodies were detected in the intestinal tract. Immunization with antigen alone induced only IgG response in the intestine.
Salmonella enteritidis-specific antibody-secreting lymphocytes were detected in the spleen and lamina propria of the intestinal tract of immunized chickens. Immunoglobulin (Ig) fractions extracted from intestines of immunized chickens inhibited the adherence of
S. enteritidis to cultured HeLa cells. These results indicate that intraocular immunization with liposome-associated
S. enteritidis elicits specific antibody-producing lymphocytes in the intestinal tract, and that Ig secreted in the intestine inhibits adherence of the bacteria to intestinal epithelial cells, suppressing the spread of bacterial infection in the host. |
| doi_str_mv | 10.1016/S0145-305X(01)00014-3 |
| format | Article |
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Salmonella enterica serovar
enteritidis was studied by immunizing chickens with liposome-associated antigen. An ultrasonicated whole cell extract of the bacteria was used for immunizing antigen. Intraocular immunization induced serum IgA, IgG and IgM responses. Also, significant IgA and IgG antibodies were detected in the intestinal tract. Immunization with antigen alone induced only IgG response in the intestine.
Salmonella enteritidis-specific antibody-secreting lymphocytes were detected in the spleen and lamina propria of the intestinal tract of immunized chickens. Immunoglobulin (Ig) fractions extracted from intestines of immunized chickens inhibited the adherence of
S. enteritidis to cultured HeLa cells. These results indicate that intraocular immunization with liposome-associated
S. enteritidis elicits specific antibody-producing lymphocytes in the intestinal tract, and that Ig secreted in the intestine inhibits adherence of the bacteria to intestinal epithelial cells, suppressing the spread of bacterial infection in the host.</description><identifier>ISSN: 0145-305X</identifier><identifier>EISSN: 1879-0089</identifier><identifier>DOI: 10.1016/S0145-305X(01)00014-3</identifier><identifier>PMID: 11356227</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Antibodies, Bacterial - immunology ; Antigens, Bacterial - immunology ; B-Lymphocytes - immunology ; Bacterial Adhesion ; Chickens ; Drug Administration Routes ; HeLa Cells ; Humans ; Immunity, Mucosal ; Immunization ; Immunoglobulins - blood ; Immunoglobulins - immunology ; Intestinal Mucosa - immunology ; Intraocular immunization ; Liposome ; Liposomes ; Mucosal immunity ; Salmonella enterica enteritidis ; Salmonella enteritidis ; Salmonella enteritidis - immunology ; Spleen - cytology ; Spleen - immunology</subject><ispartof>Developmental and comparative immunology, 2001-06, Vol.25 (5), p.475-484</ispartof><rights>2001 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-ec1411f462ff7735b27fa4181b808e91b74577c54ffaceb5ce241ce8a478d8193</citedby><cites>FETCH-LOGICAL-c392t-ec1411f462ff7735b27fa4181b808e91b74577c54ffaceb5ce241ce8a478d8193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0145-305X(01)00014-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11356227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukutome, Koichi</creatorcontrib><creatorcontrib>Watarai, Shinobu</creatorcontrib><creatorcontrib>Mukamoto, Masafumi</creatorcontrib><creatorcontrib>Kodama, Hiroshi</creatorcontrib><title>Intestinal mucosal immune response in chickens following intraocular immunization with liposome-associated Salmonella enterica serovar enteritidis antigen</title><title>Developmental and comparative immunology</title><addtitle>Dev Comp Immunol</addtitle><description>Induction of intestinal mucosal immune responses against
Salmonella enterica serovar
enteritidis was studied by immunizing chickens with liposome-associated antigen. An ultrasonicated whole cell extract of the bacteria was used for immunizing antigen. Intraocular immunization induced serum IgA, IgG and IgM responses. Also, significant IgA and IgG antibodies were detected in the intestinal tract. Immunization with antigen alone induced only IgG response in the intestine.
Salmonella enteritidis-specific antibody-secreting lymphocytes were detected in the spleen and lamina propria of the intestinal tract of immunized chickens. Immunoglobulin (Ig) fractions extracted from intestines of immunized chickens inhibited the adherence of
S. enteritidis to cultured HeLa cells. These results indicate that intraocular immunization with liposome-associated
S. enteritidis elicits specific antibody-producing lymphocytes in the intestinal tract, and that Ig secreted in the intestine inhibits adherence of the bacteria to intestinal epithelial cells, suppressing the spread of bacterial infection in the host.</description><subject>Animals</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antigens, Bacterial - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Bacterial Adhesion</subject><subject>Chickens</subject><subject>Drug Administration Routes</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Immunity, Mucosal</subject><subject>Immunization</subject><subject>Immunoglobulins - blood</subject><subject>Immunoglobulins - immunology</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intraocular immunization</subject><subject>Liposome</subject><subject>Liposomes</subject><subject>Mucosal immunity</subject><subject>Salmonella enterica enteritidis</subject><subject>Salmonella enteritidis</subject><subject>Salmonella enteritidis - immunology</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><issn>0145-305X</issn><issn>1879-0089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EotvCI4B8QnAIeJJ47ZxQVUGpVIlDQeJmOc6kHUjsxXZawaPwtHibFRx7Gs3o--cfzc_YCxBvQcD23ZWAVlaNkN9eC3gjRGmr5hHbgFZdJYTuHrPNP-SIHaf0vUBCg3jKjgAaua1rtWF_LnzGlMnbic-LC6lUmufFI4-YdsEn5OS5uyH3A33iY5imcEf-ukxztMEtk42rgn7bTMHzO8o3fKJdSGHGyqYUHNmMA7-y0xw8TpPlWFwjOcsTxnBbNqyDTAMlbn2ma_TP2JPRTgmfH-oJ-_rxw5ezT9Xl5_OLs9PLyjVdnSt00AKM7bYeR6Ua2ddqtC1o6LXQ2EGvWqmUk-04Woe9dFi34FDbVulBQ9ecsFfr3l0MP5fyDDNTcvszPYYlGSX0tpHiYbB4bmUn2gLKFXQxpBRxNLtIs42_DAizT8_cp2f20RgB5j490xTdy4PB0s84_Fcd4irA-xXA8o9bwmiSI_QOB4roshkCPWDxF7osrzE</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Fukutome, Koichi</creator><creator>Watarai, Shinobu</creator><creator>Mukamoto, Masafumi</creator><creator>Kodama, Hiroshi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Intestinal mucosal immune response in chickens following intraocular immunization with liposome-associated Salmonella enterica serovar enteritidis antigen</title><author>Fukutome, Koichi ; Watarai, Shinobu ; Mukamoto, Masafumi ; Kodama, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-ec1411f462ff7735b27fa4181b808e91b74577c54ffaceb5ce241ce8a478d8193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Antigens, Bacterial - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Bacterial Adhesion</topic><topic>Chickens</topic><topic>Drug Administration Routes</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Immunity, Mucosal</topic><topic>Immunization</topic><topic>Immunoglobulins - blood</topic><topic>Immunoglobulins - immunology</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intraocular immunization</topic><topic>Liposome</topic><topic>Liposomes</topic><topic>Mucosal immunity</topic><topic>Salmonella enterica enteritidis</topic><topic>Salmonella enteritidis</topic><topic>Salmonella enteritidis - immunology</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukutome, Koichi</creatorcontrib><creatorcontrib>Watarai, Shinobu</creatorcontrib><creatorcontrib>Mukamoto, Masafumi</creatorcontrib><creatorcontrib>Kodama, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental and comparative immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukutome, Koichi</au><au>Watarai, Shinobu</au><au>Mukamoto, Masafumi</au><au>Kodama, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal mucosal immune response in chickens following intraocular immunization with liposome-associated Salmonella enterica serovar enteritidis antigen</atitle><jtitle>Developmental and comparative immunology</jtitle><addtitle>Dev Comp Immunol</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>25</volume><issue>5</issue><spage>475</spage><epage>484</epage><pages>475-484</pages><issn>0145-305X</issn><eissn>1879-0089</eissn><abstract>Induction of intestinal mucosal immune responses against
Salmonella enterica serovar
enteritidis was studied by immunizing chickens with liposome-associated antigen. An ultrasonicated whole cell extract of the bacteria was used for immunizing antigen. Intraocular immunization induced serum IgA, IgG and IgM responses. Also, significant IgA and IgG antibodies were detected in the intestinal tract. Immunization with antigen alone induced only IgG response in the intestine.
Salmonella enteritidis-specific antibody-secreting lymphocytes were detected in the spleen and lamina propria of the intestinal tract of immunized chickens. Immunoglobulin (Ig) fractions extracted from intestines of immunized chickens inhibited the adherence of
S. enteritidis to cultured HeLa cells. These results indicate that intraocular immunization with liposome-associated
S. enteritidis elicits specific antibody-producing lymphocytes in the intestinal tract, and that Ig secreted in the intestine inhibits adherence of the bacteria to intestinal epithelial cells, suppressing the spread of bacterial infection in the host.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>11356227</pmid><doi>10.1016/S0145-305X(01)00014-3</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antibodies, Bacterial - immunology Antigens, Bacterial - immunology B-Lymphocytes - immunology Bacterial Adhesion Chickens Drug Administration Routes HeLa Cells Humans Immunity, Mucosal Immunization Immunoglobulins - blood Immunoglobulins - immunology Intestinal Mucosa - immunology Intraocular immunization Liposome Liposomes Mucosal immunity Salmonella enterica enteritidis Salmonella enteritidis Salmonella enteritidis - immunology Spleen - cytology Spleen - immunology |
| title | Intestinal mucosal immune response in chickens following intraocular immunization with liposome-associated Salmonella enterica serovar enteritidis antigen |
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