Surgically Induced Cryptorchidism-Related Degenerative Changes in Spermatogonia Are Associated with Loss of Cyclic Adenosine Monophosphate-Dependent Phosphodiesterases Type 4 in Abdominal Testes of Rats

The present study was undertaken to investigate the role of phosphodiesterase type 4 (PDE4) enzymes in cryptorchidism-induced apoptosis of the germ cells. Regulation of expression of PDE4 enzymes was studied in the abdominal and scrotal testes of surgically induced cryptorchid rats for 10, 20, and 3...

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Veröffentlicht in:	Biology of reproduction 2001-06, Vol.64 (6), p.1583-1589
Hauptverfasser:	Farooqui, Shakeel M, Al-Bagdadi, Fakhri, Houslay, Miles D, Bolger, Graeme B, Stout, R, Specian, R. D, Cherry, J. A, Conti, M, O'Donnell, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - analysis 3',5'-Cyclic-AMP Phosphodiesterases - metabolism Animals Apoptosis Biological and medical sciences Blotting, Western Contents Cryptorchidism - etiology Cryptorchidism - pathology Cryptorchidism - surgery cyclic adenosine monophosphate Cyclic Nucleotide Phosphodiesterases, Type 4 Epithelium - pathology gametogenesis gene regulation Gynecology. Andrology. Obstetrics Immunohistochemistry Male Male genital diseases Medical sciences Non tumoral diseases phosphodiesterases Rats Rats, Sprague-Dawley Seminiferous Tubules - pathology signal transduction spermatogenesis Spermatozoa - pathology Testis - enzymology
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