Coumestrol Antagonizes Neuroendocrine Actions of Estrogen via the Estrogen Receptor α

The phytoestrogen coumestrol has estrogenic actions on peripheral reproductive tissues. Yet in the brain this compound has both estrogenic and anti-estrogenic effects. We used estrogen receptor α knockout mice (ERαKO) to determine whether coumestrol has estrogenic actions in mice and also if these e...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2001-04, Vol.226 (4), p.301-306
Hauptverfasser:	Jacob, Dena A., Temple, Jennifer L., Patisaul, Heather B., Young, Larry J., Rissman, Emilie F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Coumestrol - administration & dosage Coumestrol - pharmacology Drug Evaluation, Preclinical Estradiol - administration & dosage Estradiol - pharmacology Estrogen Receptor alpha Estrogens, Non-Steroidal - pharmacology Female Hypothalamus - drug effects Hypothalamus - metabolism Luteinizing Hormone - blood Mice Mice, Knockout Ovariectomy Receptors, Estrogen - antagonists & inhibitors Receptors, Estrogen - deficiency Receptors, Estrogen - genetics Receptors, Progesterone - analysis
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