Potentially malignant oral lesions in Northern Ireland: a 20-year population-based perspective of malignant transformation
This retrospective laboratory-based study investigates the potential for malignant transformation of oral mucosal lesions in a population of 1.6 million. Over the 20-year period there were 745 patients diagnosed with primary intra-oral squamous cell carcinoma (OSCC), 165 patients with dysplasia and...
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| Veröffentlicht in: | Oral diseases 2001, Vol.7 (1), p.18-24 |
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| creator | COWAN, C. G GREGG, T. A NAPIER, S. S MCKENNA, S. M KEE, F |
| description | This retrospective laboratory-based study investigates the potential for malignant transformation of oral mucosal lesions in a population of 1.6 million. Over the 20-year period there were 745 patients diagnosed with primary intra-oral squamous cell carcinoma (OSCC), 165 patients with dysplasia and 1182 patients with 'non-dysplastic' lesions (epithelial hyperplasia, hyperkeratosis epithelial atrophy, lichen planus and lupus erythematosus). Malignant transformation occurred in 15% of dysplasias and in 1% of 'non-dysplastic' lesions at average intervals after diagnosis of 48 and 65 months respectively. Only 6% of patients with OSCC had a pre-invasive lesion biopsied. These data suggest that white lesions are only rarely the pre-invasive phase of OSCC. It is possible therefore that early changes are red, small or even microscopic with carcinoma developing without a clinically observable phase. More effective management strategies will require the development of tissue markers to enhance early detection. |
| doi_str_mv | 10.1034/j.1601-0825.2001.0070104.x |
| format | Article |
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G ; GREGG, T. A ; NAPIER, S. S ; MCKENNA, S. M ; KEE, F</creator><creatorcontrib>COWAN, C. G ; GREGG, T. A ; NAPIER, S. S ; MCKENNA, S. M ; KEE, F</creatorcontrib><description>This retrospective laboratory-based study investigates the potential for malignant transformation of oral mucosal lesions in a population of 1.6 million. Over the 20-year period there were 745 patients diagnosed with primary intra-oral squamous cell carcinoma (OSCC), 165 patients with dysplasia and 1182 patients with 'non-dysplastic' lesions (epithelial hyperplasia, hyperkeratosis epithelial atrophy, lichen planus and lupus erythematosus). Malignant transformation occurred in 15% of dysplasias and in 1% of 'non-dysplastic' lesions at average intervals after diagnosis of 48 and 65 months respectively. Only 6% of patients with OSCC had a pre-invasive lesion biopsied. These data suggest that white lesions are only rarely the pre-invasive phase of OSCC. It is possible therefore that early changes are red, small or even microscopic with carcinoma developing without a clinically observable phase. More effective management strategies will require the development of tissue markers to enhance early detection.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1034/j.1601-0825.2001.0070104.x</identifier><identifier>PMID: 11354915</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinoma, Squamous Cell - epidemiology ; Cell Transformation, Neoplastic - pathology ; Dentistry ; Epithelial Cells - pathology ; Female ; General aspects ; Humans ; Leukoplakia, Oral - epidemiology ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - epidemiology ; Northern Ireland - epidemiology ; Otorhinolaryngology. Stomatology ; Precancerous Conditions - epidemiology ; Retrospective Studies ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Oral diseases, 2001, Vol.7 (1), p.18-24</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c259t-6fb48864d808eb16b24166e18945bf45a44716075af1f585b1de85295368fc43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1051026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11354915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COWAN, C. G</creatorcontrib><creatorcontrib>GREGG, T. A</creatorcontrib><creatorcontrib>NAPIER, S. S</creatorcontrib><creatorcontrib>MCKENNA, S. M</creatorcontrib><creatorcontrib>KEE, F</creatorcontrib><title>Potentially malignant oral lesions in Northern Ireland: a 20-year population-based perspective of malignant transformation</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>This retrospective laboratory-based study investigates the potential for malignant transformation of oral mucosal lesions in a population of 1.6 million. Over the 20-year period there were 745 patients diagnosed with primary intra-oral squamous cell carcinoma (OSCC), 165 patients with dysplasia and 1182 patients with 'non-dysplastic' lesions (epithelial hyperplasia, hyperkeratosis epithelial atrophy, lichen planus and lupus erythematosus). Malignant transformation occurred in 15% of dysplasias and in 1% of 'non-dysplastic' lesions at average intervals after diagnosis of 48 and 65 months respectively. Only 6% of patients with OSCC had a pre-invasive lesion biopsied. These data suggest that white lesions are only rarely the pre-invasive phase of OSCC. It is possible therefore that early changes are red, small or even microscopic with carcinoma developing without a clinically observable phase. More effective management strategies will require the development of tissue markers to enhance early detection.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Dentistry</subject><subject>Epithelial Cells - pathology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Leukoplakia, Oral - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - epidemiology</subject><subject>Northern Ireland - epidemiology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Precancerous Conditions - epidemiology</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMFO3DAQhi1UBFvgFSqrqrgl2I7tOHurUGlXQsCBAzfLScZtVk6c2t5ql6cngahwmpHmmxn9H0JfKckpKfjVNqeS0IwoJnJGCM0JKQklPN8fodX_0aepLwTPBCueTtHnGLcTWlYFO0GndJ5UVKzQ84NPMKTOOHfAvXHd78EMCftgHHYQOz9E3A34zof0B8KANwGcGdo1NpiR7AAm4NGPO2fShGa1idDiEUIcoUndP8Defriaghmi9aF_pc_RsTUuwsVSz9DjzY_H61_Z7f3PzfX326xhokqZtDVXSvJWEQU1lTXjVEqgquKitlwYzsspdCmMpVYoUdMWlGCVKKSyDS_O0OXb2TH4vzuISfddbMBNMcDvoi6JklTwGVy_gU3wMQawegxdb8JBU6Jn8XqrZ7t6tqtn8XoRr_fT8pfly67uoX1fXUxPwLcFMLExzk4qmi5-eCEoYbJ4AezijY0</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>COWAN, C. 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M ; KEE, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-6fb48864d808eb16b24166e18945bf45a44716075af1f585b1de85295368fc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Dentistry</topic><topic>Epithelial Cells - pathology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Leukoplakia, Oral - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - epidemiology</topic><topic>Northern Ireland - epidemiology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Precancerous Conditions - epidemiology</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COWAN, C. G</creatorcontrib><creatorcontrib>GREGG, T. A</creatorcontrib><creatorcontrib>NAPIER, S. S</creatorcontrib><creatorcontrib>MCKENNA, S. M</creatorcontrib><creatorcontrib>KEE, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COWAN, C. G</au><au>GREGG, T. A</au><au>NAPIER, S. S</au><au>MCKENNA, S. M</au><au>KEE, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potentially malignant oral lesions in Northern Ireland: a 20-year population-based perspective of malignant transformation</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2001</date><risdate>2001</risdate><volume>7</volume><issue>1</issue><spage>18</spage><epage>24</epage><pages>18-24</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>This retrospective laboratory-based study investigates the potential for malignant transformation of oral mucosal lesions in a population of 1.6 million. Over the 20-year period there were 745 patients diagnosed with primary intra-oral squamous cell carcinoma (OSCC), 165 patients with dysplasia and 1182 patients with 'non-dysplastic' lesions (epithelial hyperplasia, hyperkeratosis epithelial atrophy, lichen planus and lupus erythematosus). Malignant transformation occurred in 15% of dysplasias and in 1% of 'non-dysplastic' lesions at average intervals after diagnosis of 48 and 65 months respectively. Only 6% of patients with OSCC had a pre-invasive lesion biopsied. These data suggest that white lesions are only rarely the pre-invasive phase of OSCC. It is possible therefore that early changes are red, small or even microscopic with carcinoma developing without a clinically observable phase. More effective management strategies will require the development of tissue markers to enhance early detection.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>11354915</pmid><doi>10.1034/j.1601-0825.2001.0070104.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Oral diseases, 2001, Vol.7 (1), p.18-24 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Age Distribution Aged Aged, 80 and over Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Squamous Cell - epidemiology Cell Transformation, Neoplastic - pathology Dentistry Epithelial Cells - pathology Female General aspects Humans Leukoplakia, Oral - epidemiology Male Medical sciences Middle Aged Mouth Neoplasms - epidemiology Northern Ireland - epidemiology Otorhinolaryngology. Stomatology Precancerous Conditions - epidemiology Retrospective Studies Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Potentially malignant oral lesions in Northern Ireland: a 20-year population-based perspective of malignant transformation |
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