Vitronectin in clotting factor IX concentrates

Highly purified, plasma‐derived factor IX (FIX) concentrates are produced in large part by a combination of anion exchange and heparin affinity chromatography. However, the concentrates still contain some accompanying proteins. The main impurity has turned out to be the adhesive glycoprotein, vitron...

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Veröffentlicht in:	Haemophilia : the official journal of the World Federation of Hemophilia 2001-05, Vol.7 (3), p.250-257
Hauptverfasser:	Josic, D., Kannicht, C., Löster, K., Pock, K., Iberer, G., Buchacher, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	binding Blood Coagulation Factors - chemistry Blood Coagulation Factors - isolation & purification Blood Coagulation Factors - standards Chromatography, High Pressure Liquid coagulation factor IX concentrates Dimerization Drug Contamination Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay heparin Humans multimeric forms Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization vitronectin Vitronectin - analysis Vitronectin - immunology Vitronectin - metabolism
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