Effect of additives on the physicochemical properties of liquid suppository bases
To investigate the effects of additives on the physicochemical properties of in situ gelling and mucoadhesive liquid suppository base, gelation temperature, gel strength and bioadhesive force of liquid suppository base, poloxamer 407 (P 407) and poloxamer 188 (P 188) (15/15%) were evaluated in the p...
Gespeichert in:
| Veröffentlicht in: | International journal of pharmaceutics 1999-11, Vol.190 (1), p.13-19 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 19 |
|---|---|
| container_issue | 1 |
| container_start_page | 13 |
| container_title | International journal of pharmaceutics |
| container_volume | 190 |
| creator | Choi, Han-Gon Lee, Mi-Kyung Kim, Moon-Hee Kim, Chong-Kook |
| description | To investigate the effects of additives on the physicochemical properties of in situ gelling and mucoadhesive liquid suppository base, gelation temperature, gel strength and bioadhesive force of liquid suppository base, poloxamer 407 (P 407) and poloxamer 188 (P 188) (15/15%) were evaluated in the presence of following additives: solvent (ethanol, propylene glycol, glycerin), ionic strength-controlling agent (sodium chloride) and pH-controlling agent (hydrochloric acid, sodium monohydrogen phosphate, sodium dihydrogen phosphate). Among the additives studied, sodium chloride, sodium monohydrogen phosphate and sodium dihydrogen phosphate increased to a great extent the gel strength and the bioadhesive force of P 407/P 188 (15/15%) with a decrease in gelation temperature. Glycerin slightly decreased the gelation temperature and slightly increased the gel strength and bioadhesive force. However, the addition of 1% of sodium chloride, sodium monohydrogen phosphate or sodium dihydrogen phosphate caused a greater than 60-fold increase in gel strength and over a tenfold increase in bioadhesive force with 2–4°C decrease of gelation temperature within optimal range, compared with P 407/P 188 (15/15%) alone. On the other hand, ethanol, propylene glycol and hydrochloric acid increased the gelation temperature and slightly decreased the gel strength and the bioadhesive force. Taken together, these findings indicate that the effect of additives on the physicochemical properties of liquid suppository bases depends on their bonding capacities, in that additives such as sodium chloride, sodium monohydrogen phosphate and sodium dihydrogen phosphate having strong cross-linking bonds with the components of liquid suppository base increase the strength and bioadhesive force of a gel compared to liquid suppository base alone, while additives such as ethanol, propylene glycol and hydrochloric acid having weaker hydrogen bonding result in a weaker response. Thus, sodium chloride and sodium phosphates appear to be promising additives for in situ gelling and mucoadhesive liquid suppository base, if used in adequate amounts. |
| doi_str_mv | 10.1016/S0378-5173(99)00225-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70861294</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517399002252</els_id><sourcerecordid>70861294</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-b94e30410c12e046378df522999e0b428456df0fe666fd5baa3e6abbd2feb8d53</originalsourceid><addsrcrecordid>eNqF0E2LFDEQgOEgijuu_gQlBxE9tFaS7nTnJLKsH7Agop5DOqkwkZ5Jb6p7Yf69mZ1BvXnK5alK8TL2XMBbAUK_-w6qH5pO9Oq1MW8ApOwa-YBtxNCrRrW9fsg2f8gFe0L0CwC0FOoxuxDQyQGM3LBv1zGiX3iO3IWQlnSHxPOeL1vk8_ZAyWe_xV3ybuJzyTOWJR1F5FO6XVPgtM5zprTkcuCjI6Sn7FF0E-Gz83vJfn68_nH1ubn5-unL1YebxredXprRtKigFeCFRGh1PTXETkpjDMLYyqGqECGi1jqGbnROoXbjGGTEcQidumSvTnvrWbcr0mJ3iTxOk9tjXsn2MGghTVthd4K-ZKKC0c4l7Vw5WAH22NLet7THUNYYe9_Syjr34vzBOu4w_DN1ilfByzNwVPvE4vY-0V8n-mFQprL3J4a1xl3CYskn3HsMqdT0NuT0n0t-A6DRkWc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70861294</pqid></control><display><type>article</type><title>Effect of additives on the physicochemical properties of liquid suppository bases</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Choi, Han-Gon ; Lee, Mi-Kyung ; Kim, Moon-Hee ; Kim, Chong-Kook</creator><creatorcontrib>Choi, Han-Gon ; Lee, Mi-Kyung ; Kim, Moon-Hee ; Kim, Chong-Kook</creatorcontrib><description>To investigate the effects of additives on the physicochemical properties of in situ gelling and mucoadhesive liquid suppository base, gelation temperature, gel strength and bioadhesive force of liquid suppository base, poloxamer 407 (P 407) and poloxamer 188 (P 188) (15/15%) were evaluated in the presence of following additives: solvent (ethanol, propylene glycol, glycerin), ionic strength-controlling agent (sodium chloride) and pH-controlling agent (hydrochloric acid, sodium monohydrogen phosphate, sodium dihydrogen phosphate). Among the additives studied, sodium chloride, sodium monohydrogen phosphate and sodium dihydrogen phosphate increased to a great extent the gel strength and the bioadhesive force of P 407/P 188 (15/15%) with a decrease in gelation temperature. Glycerin slightly decreased the gelation temperature and slightly increased the gel strength and bioadhesive force. However, the addition of 1% of sodium chloride, sodium monohydrogen phosphate or sodium dihydrogen phosphate caused a greater than 60-fold increase in gel strength and over a tenfold increase in bioadhesive force with 2–4°C decrease of gelation temperature within optimal range, compared with P 407/P 188 (15/15%) alone. On the other hand, ethanol, propylene glycol and hydrochloric acid increased the gelation temperature and slightly decreased the gel strength and the bioadhesive force. Taken together, these findings indicate that the effect of additives on the physicochemical properties of liquid suppository bases depends on their bonding capacities, in that additives such as sodium chloride, sodium monohydrogen phosphate and sodium dihydrogen phosphate having strong cross-linking bonds with the components of liquid suppository base increase the strength and bioadhesive force of a gel compared to liquid suppository base alone, while additives such as ethanol, propylene glycol and hydrochloric acid having weaker hydrogen bonding result in a weaker response. Thus, sodium chloride and sodium phosphates appear to be promising additives for in situ gelling and mucoadhesive liquid suppository base, if used in adequate amounts.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/S0378-5173(99)00225-2</identifier><identifier>PMID: 10528092</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adhesiveness ; Bioadhesive force ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; Drug Compounding ; Ethanol - chemistry ; Gel strength ; Gelation temperature ; Gels ; General pharmacology ; Glycerol - chemistry ; Hydrochloric Acid - chemistry ; Hydrogen-Ion Concentration ; Liquid suppository base ; Medical sciences ; Osmolar Concentration ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Phosphates - chemistry ; Poloxamer ; Poloxamer - chemistry ; Propylene Glycol - chemistry ; Sodium Chloride - chemistry ; Solvents - chemistry ; Suppositories - chemistry ; Temperature</subject><ispartof>International journal of pharmaceutics, 1999-11, Vol.190 (1), p.13-19</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-b94e30410c12e046378df522999e0b428456df0fe666fd5baa3e6abbd2feb8d53</citedby><cites>FETCH-LOGICAL-c456t-b94e30410c12e046378df522999e0b428456df0fe666fd5baa3e6abbd2feb8d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517399002252$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1178839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10528092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Han-Gon</creatorcontrib><creatorcontrib>Lee, Mi-Kyung</creatorcontrib><creatorcontrib>Kim, Moon-Hee</creatorcontrib><creatorcontrib>Kim, Chong-Kook</creatorcontrib><title>Effect of additives on the physicochemical properties of liquid suppository bases</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>To investigate the effects of additives on the physicochemical properties of in situ gelling and mucoadhesive liquid suppository base, gelation temperature, gel strength and bioadhesive force of liquid suppository base, poloxamer 407 (P 407) and poloxamer 188 (P 188) (15/15%) were evaluated in the presence of following additives: solvent (ethanol, propylene glycol, glycerin), ionic strength-controlling agent (sodium chloride) and pH-controlling agent (hydrochloric acid, sodium monohydrogen phosphate, sodium dihydrogen phosphate). Among the additives studied, sodium chloride, sodium monohydrogen phosphate and sodium dihydrogen phosphate increased to a great extent the gel strength and the bioadhesive force of P 407/P 188 (15/15%) with a decrease in gelation temperature. Glycerin slightly decreased the gelation temperature and slightly increased the gel strength and bioadhesive force. However, the addition of 1% of sodium chloride, sodium monohydrogen phosphate or sodium dihydrogen phosphate caused a greater than 60-fold increase in gel strength and over a tenfold increase in bioadhesive force with 2–4°C decrease of gelation temperature within optimal range, compared with P 407/P 188 (15/15%) alone. On the other hand, ethanol, propylene glycol and hydrochloric acid increased the gelation temperature and slightly decreased the gel strength and the bioadhesive force. Taken together, these findings indicate that the effect of additives on the physicochemical properties of liquid suppository bases depends on their bonding capacities, in that additives such as sodium chloride, sodium monohydrogen phosphate and sodium dihydrogen phosphate having strong cross-linking bonds with the components of liquid suppository base increase the strength and bioadhesive force of a gel compared to liquid suppository base alone, while additives such as ethanol, propylene glycol and hydrochloric acid having weaker hydrogen bonding result in a weaker response. Thus, sodium chloride and sodium phosphates appear to be promising additives for in situ gelling and mucoadhesive liquid suppository base, if used in adequate amounts.</description><subject>Adhesiveness</subject><subject>Bioadhesive force</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Drug Compounding</subject><subject>Ethanol - chemistry</subject><subject>Gel strength</subject><subject>Gelation temperature</subject><subject>Gels</subject><subject>General pharmacology</subject><subject>Glycerol - chemistry</subject><subject>Hydrochloric Acid - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Liquid suppository base</subject><subject>Medical sciences</subject><subject>Osmolar Concentration</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphates - chemistry</subject><subject>Poloxamer</subject><subject>Poloxamer - chemistry</subject><subject>Propylene Glycol - chemistry</subject><subject>Sodium Chloride - chemistry</subject><subject>Solvents - chemistry</subject><subject>Suppositories - chemistry</subject><subject>Temperature</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E2LFDEQgOEgijuu_gQlBxE9tFaS7nTnJLKsH7Agop5DOqkwkZ5Jb6p7Yf69mZ1BvXnK5alK8TL2XMBbAUK_-w6qH5pO9Oq1MW8ApOwa-YBtxNCrRrW9fsg2f8gFe0L0CwC0FOoxuxDQyQGM3LBv1zGiX3iO3IWQlnSHxPOeL1vk8_ZAyWe_xV3ybuJzyTOWJR1F5FO6XVPgtM5zprTkcuCjI6Sn7FF0E-Gz83vJfn68_nH1ubn5-unL1YebxredXprRtKigFeCFRGh1PTXETkpjDMLYyqGqECGi1jqGbnROoXbjGGTEcQidumSvTnvrWbcr0mJ3iTxOk9tjXsn2MGghTVthd4K-ZKKC0c4l7Vw5WAH22NLet7THUNYYe9_Syjr34vzBOu4w_DN1ilfByzNwVPvE4vY-0V8n-mFQprL3J4a1xl3CYskn3HsMqdT0NuT0n0t-A6DRkWc</recordid><startdate>19991110</startdate><enddate>19991110</enddate><creator>Choi, Han-Gon</creator><creator>Lee, Mi-Kyung</creator><creator>Kim, Moon-Hee</creator><creator>Kim, Chong-Kook</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991110</creationdate><title>Effect of additives on the physicochemical properties of liquid suppository bases</title><author>Choi, Han-Gon ; Lee, Mi-Kyung ; Kim, Moon-Hee ; Kim, Chong-Kook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-b94e30410c12e046378df522999e0b428456df0fe666fd5baa3e6abbd2feb8d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adhesiveness</topic><topic>Bioadhesive force</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Drug Compounding</topic><topic>Ethanol - chemistry</topic><topic>Gel strength</topic><topic>Gelation temperature</topic><topic>Gels</topic><topic>General pharmacology</topic><topic>Glycerol - chemistry</topic><topic>Hydrochloric Acid - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Liquid suppository base</topic><topic>Medical sciences</topic><topic>Osmolar Concentration</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphates - chemistry</topic><topic>Poloxamer</topic><topic>Poloxamer - chemistry</topic><topic>Propylene Glycol - chemistry</topic><topic>Sodium Chloride - chemistry</topic><topic>Solvents - chemistry</topic><topic>Suppositories - chemistry</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Han-Gon</creatorcontrib><creatorcontrib>Lee, Mi-Kyung</creatorcontrib><creatorcontrib>Kim, Moon-Hee</creatorcontrib><creatorcontrib>Kim, Chong-Kook</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Han-Gon</au><au>Lee, Mi-Kyung</au><au>Kim, Moon-Hee</au><au>Kim, Chong-Kook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of additives on the physicochemical properties of liquid suppository bases</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>1999-11-10</date><risdate>1999</risdate><volume>190</volume><issue>1</issue><spage>13</spage><epage>19</epage><pages>13-19</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>To investigate the effects of additives on the physicochemical properties of in situ gelling and mucoadhesive liquid suppository base, gelation temperature, gel strength and bioadhesive force of liquid suppository base, poloxamer 407 (P 407) and poloxamer 188 (P 188) (15/15%) were evaluated in the presence of following additives: solvent (ethanol, propylene glycol, glycerin), ionic strength-controlling agent (sodium chloride) and pH-controlling agent (hydrochloric acid, sodium monohydrogen phosphate, sodium dihydrogen phosphate). Among the additives studied, sodium chloride, sodium monohydrogen phosphate and sodium dihydrogen phosphate increased to a great extent the gel strength and the bioadhesive force of P 407/P 188 (15/15%) with a decrease in gelation temperature. Glycerin slightly decreased the gelation temperature and slightly increased the gel strength and bioadhesive force. However, the addition of 1% of sodium chloride, sodium monohydrogen phosphate or sodium dihydrogen phosphate caused a greater than 60-fold increase in gel strength and over a tenfold increase in bioadhesive force with 2–4°C decrease of gelation temperature within optimal range, compared with P 407/P 188 (15/15%) alone. On the other hand, ethanol, propylene glycol and hydrochloric acid increased the gelation temperature and slightly decreased the gel strength and the bioadhesive force. Taken together, these findings indicate that the effect of additives on the physicochemical properties of liquid suppository bases depends on their bonding capacities, in that additives such as sodium chloride, sodium monohydrogen phosphate and sodium dihydrogen phosphate having strong cross-linking bonds with the components of liquid suppository base increase the strength and bioadhesive force of a gel compared to liquid suppository base alone, while additives such as ethanol, propylene glycol and hydrochloric acid having weaker hydrogen bonding result in a weaker response. Thus, sodium chloride and sodium phosphates appear to be promising additives for in situ gelling and mucoadhesive liquid suppository base, if used in adequate amounts.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10528092</pmid><doi>10.1016/S0378-5173(99)00225-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 1999-11, Vol.190 (1), p.13-19 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70861294 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adhesiveness Bioadhesive force Biological and medical sciences Chemical Phenomena Chemistry, Physical Drug Compounding Ethanol - chemistry Gel strength Gelation temperature Gels General pharmacology Glycerol - chemistry Hydrochloric Acid - chemistry Hydrogen-Ion Concentration Liquid suppository base Medical sciences Osmolar Concentration Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphates - chemistry Poloxamer Poloxamer - chemistry Propylene Glycol - chemistry Sodium Chloride - chemistry Solvents - chemistry Suppositories - chemistry Temperature |
| title | Effect of additives on the physicochemical properties of liquid suppository bases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A21%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20additives%20on%20the%20physicochemical%20properties%20of%20liquid%20suppository%20bases&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.au=Choi,%20Han-Gon&rft.date=1999-11-10&rft.volume=190&rft.issue=1&rft.spage=13&rft.epage=19&rft.pages=13-19&rft.issn=0378-5173&rft.eissn=1873-3476&rft.coden=IJPHDE&rft_id=info:doi/10.1016/S0378-5173(99)00225-2&rft_dat=%3Cproquest_cross%3E70861294%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70861294&rft_id=info:pmid/10528092&rft_els_id=S0378517399002252&rfr_iscdi=true |