Disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and d-amphetamine in rats

The locomotor stimulant effects of nicotine and amphetamine appear to be dependent on dopamine transmission in the nucleus accumbens. The present aim was to elucidate the contributions of the accumbens core and medial shell to these effects. In the first experiment, rats received bilateral intra-acc...

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Veröffentlicht in:	Neuropharmacology 2001-05, Vol.40 (6), p.792-805
Hauptverfasser:	Boye, Sandra M, Grant, Rebecca J, Clarke, Paul B.S
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Adrenergic Agents Amphetamine Animals Biological and medical sciences Dextroamphetamine - pharmacology Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Drug addictions Eticlopride Locomotion Male Medical sciences Motor Activity - drug effects Motor Activity - physiology Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - injuries Nucleus Accumbens - physiology Oxidopamine Rats Rats, Sprague-Dawley Tobacco, tobacco smoking Toxicology
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