Auxotrophic, plasmid-cured Salmonella enterica serovar typhimurium for use as a live vaccine in calves
Calves were vaccinated orally, subcutaneously or intraperitoneally with a smooth, plasmid-cured strain of Salmonella enterica serovar typhimurium, strain 81. Oral vaccination was not effective, as only 1/5 calves survived challenge with virulent S. typhimurium. Strain 81 was attenuated for calves, a...
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| Veröffentlicht in: | Veterinary microbiology 2001-06, Vol.80 (4), p.373-381 |
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| creator | Van der Walt, M.L Vorster, J.H Steyn, H.C Greeff, A.S |
| description | Calves were vaccinated orally, subcutaneously or intraperitoneally with a smooth, plasmid-cured strain of
Salmonella enterica serovar
typhimurium, strain 81. Oral vaccination was not effective, as only 1/5 calves survived challenge with virulent
S. typhimurium. Strain 81 was attenuated for calves, as only a slight rise in rectal temperatures was detected after vaccination. The organism was excreted by some calves in the faeces, but no signs of diarrhoea were observed after vaccination. After parenteral vaccination, strain 81 was able to reach the intestines, gastric associated lymphoid tissues and other internal lymphoid tissues and remained viable for up to 14 days in the bovine host. After oral challenge with a virulent strain, 9/10 vaccinated calves survived challenge as opposed to 4/10 control calves (
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| doi_str_mv | 10.1016/S0378-1135(01)00325-X |
| format | Article |
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Salmonella enterica serovar
typhimurium, strain 81. Oral vaccination was not effective, as only 1/5 calves survived challenge with virulent
S. typhimurium. Strain 81 was attenuated for calves, as only a slight rise in rectal temperatures was detected after vaccination. The organism was excreted by some calves in the faeces, but no signs of diarrhoea were observed after vaccination. After parenteral vaccination, strain 81 was able to reach the intestines, gastric associated lymphoid tissues and other internal lymphoid tissues and remained viable for up to 14 days in the bovine host. After oral challenge with a virulent strain, 9/10 vaccinated calves survived challenge as opposed to 4/10 control calves (
p<0.5). Diarrhoea was present in all calves of the control groups, but in only 4/10 of the vaccinated calves. The clinical reactions of the vaccinated calves were milder than in the control calves, as the rises in rectal temperatures were lower, diarrhoea was less severe, and the challenge strain was present in fewer organs from vaccinated calves than control calves. This study showed that parenterally administered
Salmonella vaccines can induce both mucosal and systemic immunity, and it is postulated that this capability of strain 81 is related to its colonisation of lymphoid tissues and other systemic and intestinal tissues. This study confirmed that plasmid-cured strains were attenuated in the bovine host and conferred significant protection after parenteral vaccination, but not oral vaccination.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/S0378-1135(01)00325-X</identifier><identifier>PMID: 11348774</identifier><identifier>CODEN: VMICDQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Administration, Oral ; Animals ; Applied microbiology ; Biological and medical sciences ; Body Temperature ; Cattle ; Cattle Diseases - prevention & control ; Cattle-bacteria ; Diarrhea - microbiology ; Diarrhea - prevention & control ; Diarrhea - veterinary ; Fundamental and applied biological sciences. Psychology ; Injections, Intraperitoneal - veterinary ; Injections, Subcutaneous - veterinary ; Microbiology ; Plasmid-cured vaccine ; Plasmids ; Salmonella enterica typhimurium ; Salmonella Infections, Animal - immunology ; Salmonella Infections, Animal - prevention & control ; Salmonella typhimurium ; Salmonella typhimurium - immunology ; Salmonella Vaccines - administration & dosage ; Salmonella Vaccines - immunology ; Vaccination - veterinary ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Virology</subject><ispartof>Veterinary microbiology, 2001-06, Vol.80 (4), p.373-381</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-29df9ed46415b34f035f41033354acdb5106a2d85c636612f95eacd1b5b4ac483</citedby><cites>FETCH-LOGICAL-c422t-29df9ed46415b34f035f41033354acdb5106a2d85c636612f95eacd1b5b4ac483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037811350100325X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14160386$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11348774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van der Walt, M.L</creatorcontrib><creatorcontrib>Vorster, J.H</creatorcontrib><creatorcontrib>Steyn, H.C</creatorcontrib><creatorcontrib>Greeff, A.S</creatorcontrib><title>Auxotrophic, plasmid-cured Salmonella enterica serovar typhimurium for use as a live vaccine in calves</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>Calves were vaccinated orally, subcutaneously or intraperitoneally with a smooth, plasmid-cured strain of
Salmonella enterica serovar
typhimurium, strain 81. Oral vaccination was not effective, as only 1/5 calves survived challenge with virulent
S. typhimurium. Strain 81 was attenuated for calves, as only a slight rise in rectal temperatures was detected after vaccination. The organism was excreted by some calves in the faeces, but no signs of diarrhoea were observed after vaccination. After parenteral vaccination, strain 81 was able to reach the intestines, gastric associated lymphoid tissues and other internal lymphoid tissues and remained viable for up to 14 days in the bovine host. After oral challenge with a virulent strain, 9/10 vaccinated calves survived challenge as opposed to 4/10 control calves (
p<0.5). Diarrhoea was present in all calves of the control groups, but in only 4/10 of the vaccinated calves. The clinical reactions of the vaccinated calves were milder than in the control calves, as the rises in rectal temperatures were lower, diarrhoea was less severe, and the challenge strain was present in fewer organs from vaccinated calves than control calves. This study showed that parenterally administered
Salmonella vaccines can induce both mucosal and systemic immunity, and it is postulated that this capability of strain 81 is related to its colonisation of lymphoid tissues and other systemic and intestinal tissues. This study confirmed that plasmid-cured strains were attenuated in the bovine host and conferred significant protection after parenteral vaccination, but not oral vaccination.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Body Temperature</subject><subject>Cattle</subject><subject>Cattle Diseases - prevention & control</subject><subject>Cattle-bacteria</subject><subject>Diarrhea - microbiology</subject><subject>Diarrhea - prevention & control</subject><subject>Diarrhea - veterinary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraperitoneal - veterinary</subject><subject>Injections, Subcutaneous - veterinary</subject><subject>Microbiology</subject><subject>Plasmid-cured vaccine</subject><subject>Plasmids</subject><subject>Salmonella enterica typhimurium</subject><subject>Salmonella Infections, Animal - immunology</subject><subject>Salmonella Infections, Animal - prevention & control</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - immunology</subject><subject>Salmonella Vaccines - administration & dosage</subject><subject>Salmonella Vaccines - immunology</subject><subject>Vaccination - veterinary</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Virology</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rFTEUxYMo9rX6JyjZKAqO3kw-ZmZVSqlaKHTRFroLmeQGIzOTZzIz2P_evL6HXXZ14dzfycc5hLxj8JUBU99ugDdtxRiXn4B9BuC1rO5fkA1rG17VUtQvyeY_ckSOc_4NAKJT8JocFU20TSM2xJ8tf-Oc4vZXsF_odjB5DK6yS0JHb8wwxgmHwVCcZkzBGpoxxdUkOj8Ux7iksIzUx0SXjNRkaugQVqSrsTZMSMNErRlWzG_IK2-GjG8P84Tcfb-4Pf9ZXV3_uDw_u6qsqOu5qjvnO3RCCSZ7Ljxw6QUDzrkUxrpeMlCmdq20iivFat9JLDrrZV_2ouUn5OP-3G2KfxbMsx5DtrsvTBiXrBtoZddIeBZkTduplrMCyj1oU8w5odfbFEaTHjQDvWtCPzahdzFrYPqxCX1ffO8PFyz9iO7JdYi-AB8OgMklJJ_MZEN-4gRTwFtVuNM9hyW3NWDS2QacLLqQ0M7axfDMU_4B73il3g</recordid><startdate>20010622</startdate><enddate>20010622</enddate><creator>Van der Walt, M.L</creator><creator>Vorster, J.H</creator><creator>Steyn, H.C</creator><creator>Greeff, A.S</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010622</creationdate><title>Auxotrophic, plasmid-cured Salmonella enterica serovar typhimurium for use as a live vaccine in calves</title><author>Van der Walt, M.L ; Vorster, J.H ; Steyn, H.C ; Greeff, A.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-29df9ed46415b34f035f41033354acdb5106a2d85c636612f95eacd1b5b4ac483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Body Temperature</topic><topic>Cattle</topic><topic>Cattle Diseases - prevention & control</topic><topic>Cattle-bacteria</topic><topic>Diarrhea - microbiology</topic><topic>Diarrhea - prevention & control</topic><topic>Diarrhea - veterinary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraperitoneal - veterinary</topic><topic>Injections, Subcutaneous - veterinary</topic><topic>Microbiology</topic><topic>Plasmid-cured vaccine</topic><topic>Plasmids</topic><topic>Salmonella enterica typhimurium</topic><topic>Salmonella Infections, Animal - immunology</topic><topic>Salmonella Infections, Animal - prevention & control</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - immunology</topic><topic>Salmonella Vaccines - administration & dosage</topic><topic>Salmonella Vaccines - immunology</topic><topic>Vaccination - veterinary</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van der Walt, M.L</creatorcontrib><creatorcontrib>Vorster, J.H</creatorcontrib><creatorcontrib>Steyn, H.C</creatorcontrib><creatorcontrib>Greeff, A.S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van der Walt, M.L</au><au>Vorster, J.H</au><au>Steyn, H.C</au><au>Greeff, A.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auxotrophic, plasmid-cured Salmonella enterica serovar typhimurium for use as a live vaccine in calves</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>2001-06-22</date><risdate>2001</risdate><volume>80</volume><issue>4</issue><spage>373</spage><epage>381</epage><pages>373-381</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><coden>VMICDQ</coden><abstract>Calves were vaccinated orally, subcutaneously or intraperitoneally with a smooth, plasmid-cured strain of
Salmonella enterica serovar
typhimurium, strain 81. Oral vaccination was not effective, as only 1/5 calves survived challenge with virulent
S. typhimurium. Strain 81 was attenuated for calves, as only a slight rise in rectal temperatures was detected after vaccination. The organism was excreted by some calves in the faeces, but no signs of diarrhoea were observed after vaccination. After parenteral vaccination, strain 81 was able to reach the intestines, gastric associated lymphoid tissues and other internal lymphoid tissues and remained viable for up to 14 days in the bovine host. After oral challenge with a virulent strain, 9/10 vaccinated calves survived challenge as opposed to 4/10 control calves (
p<0.5). Diarrhoea was present in all calves of the control groups, but in only 4/10 of the vaccinated calves. The clinical reactions of the vaccinated calves were milder than in the control calves, as the rises in rectal temperatures were lower, diarrhoea was less severe, and the challenge strain was present in fewer organs from vaccinated calves than control calves. This study showed that parenterally administered
Salmonella vaccines can induce both mucosal and systemic immunity, and it is postulated that this capability of strain 81 is related to its colonisation of lymphoid tissues and other systemic and intestinal tissues. This study confirmed that plasmid-cured strains were attenuated in the bovine host and conferred significant protection after parenteral vaccination, but not oral vaccination.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11348774</pmid><doi>10.1016/S0378-1135(01)00325-X</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-1135 |
| ispartof | Veterinary microbiology, 2001-06, Vol.80 (4), p.373-381 |
| issn | 0378-1135 1873-2542 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Animals Applied microbiology Biological and medical sciences Body Temperature Cattle Cattle Diseases - prevention & control Cattle-bacteria Diarrhea - microbiology Diarrhea - prevention & control Diarrhea - veterinary Fundamental and applied biological sciences. Psychology Injections, Intraperitoneal - veterinary Injections, Subcutaneous - veterinary Microbiology Plasmid-cured vaccine Plasmids Salmonella enterica typhimurium Salmonella Infections, Animal - immunology Salmonella Infections, Animal - prevention & control Salmonella typhimurium Salmonella typhimurium - immunology Salmonella Vaccines - administration & dosage Salmonella Vaccines - immunology Vaccination - veterinary Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology |
| title | Auxotrophic, plasmid-cured Salmonella enterica serovar typhimurium for use as a live vaccine in calves |
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