Static Pressure Regulates Connective Tissue Growth Factor Expression in Human Mesangial Cells

Connective tissue growth factor (CTGF) is overexpressed in a variety of fibrotic disorders such as renal fibrosis and atherosclerosis. Fibrosis is a common final pathway of renal diseases of diverse etiology, including inflammation, hemodynamics, and metabolic injury. Mechanical strains such as stre...

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Veröffentlicht in:	The Journal of biological chemistry 2001-05, Vol.276 (20), p.16797-16803
Hauptverfasser:	Hishikawa, K, Oemar, B S, Nakaki, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - physiology Base Sequence Cell Division Cell Survival Cells, Cultured Collagen - genetics Connective Tissue Growth Factor CTGF protein DNA Fragmentation Enzyme Inhibitors - pharmacology Extracellular Matrix Proteins - genetics Gene Expression Regulation - physiology Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism glomerulosclerosis Growth Substances - genetics Growth Substances - pharmacology Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - pharmacology Intercellular Signaling Peptides and Proteins Laminin - genetics mesangium Mitogens - pharmacology Oligodeoxyribonucleotides, Antisense - pharmacology Pressure Protein Kinase C - metabolism Recombinant Proteins - pharmacology Transforming Growth Factor beta - immunology Transforming Growth Factor beta - physiology
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