Modulation of in Vivo HSP70 Chaperone Activity by Hip and Bag-1

The chaperone activity of Hsp70 is influenced by the activities of both positive and negative regulatory proteins. In this study, we provide first time evidence for the stimulating effect of the Hsp70-interacting protein Hip on the chaperone activity in the mammalian cytosol. Overexpressing Hip enha...

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Veröffentlicht in:	The Journal of biological chemistry 2001-02, Vol.276 (7), p.4677-4682
Hauptverfasser:	Nollen, Ellen A.A., Kabakov, Alexander E., Brunsting, Jeanette F., Kanon, Bart, Höhfeld, Jörg, Kampinga, Harm H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Bag-1 protein Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line CHO Cells Cricetinae DNA-Binding Proteins hip protein HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Luciferases - metabolism Protein Folding Protein Structure, Tertiary Transcription Factors Transfection Tumor Suppressor Proteins
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