Compromised development of calves ( [formula omitted][formula omitted]) derived from in vitro-generated embryos and transferred interspecifically into domestic cattle ( [formula omitted][formula omitted])
Advanced reproductive technologies, including IVF and interspecies embryo transfer, are becoming increasingly important for the preservation of endangered species. Previous attempts at interspecies transfer between Bos gaurus and bos taurus have yielded compromised offspring. The goal of this invest...
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| Veröffentlicht in: | Theriogenology 2001-04, Vol.55 (7), p.1447-1455 |
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| creator | Hammer, C.J. Tyler, H.D. Loskutoff, N.M. Armstrong, D.L. Funk, D.J. Lindsey, B.R. Simmons, L.G. |
| description | Advanced reproductive technologies, including IVF and interspecies embryo transfer, are becoming increasingly important for the preservation of endangered species. Previous attempts at interspecies transfer between
Bos
gaurus
and
bos
taurus
have yielded compromised offspring. The goal of this investigation was to characterize the effects of interspecies transfer of IVF-derived embryos on subsequent neonatal outcome. To achieve this goal, fresh
Bos
gaurus
IVF-derived embryos were transferred into Holstein (
Bos
taurus
) recipients. Four fetuses were carried to term. Calf weight, temperature, heart rate, and respiration rate were recorded after birth. Blood samples also were obtained for determination of blood glucose, pH, packed cell volume (PCV), total hemoglobin (tHB), Po
2, and Pco
2. After parturition, milk production and health status of the recipients were recorded. Two calves were alive at birth, and two calves were stillborn. One of the calves that was born alive died within minutes after birth, while the other lived until approximately 26 h of age. Blood samples obtained from the calf that lived for 26 h showed it to be extremely acidotic and hypoglycemic; this calf also had marked difficulty thermoregulating. At necrospy, all calves showed evidence of in utero gasping and hypoxia, suggestive of premature placental separation. None of the recipient cows showed typical signs of impending parturition. After parturition, lactogenesis in all recipient cows was markedly decreased. On gross examination, placentae resulting from the interespecies transfers had fewer cotyledons that were also much larger in size compared to cotyledons from normal gaur placetae. Calves in this study had abnormalities consistent with those noted from previous interspecies transfers and with IVF and nuclear transfer (cloned) calves. Due to the design of this study, it is not possible to differentiate between problems resulting from the IVF process and those resulting from potential interspecies incompatibilities. However, interspecies transfers of in vitro-produced gaur embryos into
Bos
taurus
are strongly discouraged. |
| doi_str_mv | 10.1016/S0093-691X(01)00493-9 |
| format | Article |
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Bos
gaurus
and
bos
taurus
have yielded compromised offspring. The goal of this investigation was to characterize the effects of interspecies transfer of IVF-derived embryos on subsequent neonatal outcome. To achieve this goal, fresh
Bos
gaurus
IVF-derived embryos were transferred into Holstein (
Bos
taurus
) recipients. Four fetuses were carried to term. Calf weight, temperature, heart rate, and respiration rate were recorded after birth. Blood samples also were obtained for determination of blood glucose, pH, packed cell volume (PCV), total hemoglobin (tHB), Po
2, and Pco
2. After parturition, milk production and health status of the recipients were recorded. Two calves were alive at birth, and two calves were stillborn. One of the calves that was born alive died within minutes after birth, while the other lived until approximately 26 h of age. Blood samples obtained from the calf that lived for 26 h showed it to be extremely acidotic and hypoglycemic; this calf also had marked difficulty thermoregulating. At necrospy, all calves showed evidence of in utero gasping and hypoxia, suggestive of premature placental separation. None of the recipient cows showed typical signs of impending parturition. After parturition, lactogenesis in all recipient cows was markedly decreased. On gross examination, placentae resulting from the interespecies transfers had fewer cotyledons that were also much larger in size compared to cotyledons from normal gaur placetae. Calves in this study had abnormalities consistent with those noted from previous interspecies transfers and with IVF and nuclear transfer (cloned) calves. Due to the design of this study, it is not possible to differentiate between problems resulting from the IVF process and those resulting from potential interspecies incompatibilities. However, interspecies transfers of in vitro-produced gaur embryos into
Bos
taurus
are strongly discouraged.</description><identifier>ISSN: 0093-691X</identifier><identifier>EISSN: 1879-3231</identifier><identifier>DOI: 10.1016/S0093-691X(01)00493-9</identifier><identifier>PMID: 11354705</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acidosis - veterinary ; Animals ; Cattle - embryology ; Cattle Diseases - pathology ; embryo transfer ; Embryo Transfer - veterinary ; Female ; Fertilization in Vitro - veterinary ; Fetal Death - veterinary ; Fetal Hypoxia - pathology ; Fetal Hypoxia - veterinary ; Hypoglycemia - veterinary ; in-vitro fertilization ; Lactation ; Male ; neonatal development ; Placenta - pathology ; Pregnancy ; Species Specificity</subject><ispartof>Theriogenology, 2001-04, Vol.55 (7), p.1447-1455</ispartof><rights>2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-a1b7e90f9137f26b0d8296a074745f9d8f052567f1c308397a1e4a2158854ecd3</citedby><cites>FETCH-LOGICAL-c361t-a1b7e90f9137f26b0d8296a074745f9d8f052567f1c308397a1e4a2158854ecd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0093691X01004939$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27902,27903,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11354705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammer, C.J.</creatorcontrib><creatorcontrib>Tyler, H.D.</creatorcontrib><creatorcontrib>Loskutoff, N.M.</creatorcontrib><creatorcontrib>Armstrong, D.L.</creatorcontrib><creatorcontrib>Funk, D.J.</creatorcontrib><creatorcontrib>Lindsey, B.R.</creatorcontrib><creatorcontrib>Simmons, L.G.</creatorcontrib><title>Compromised development of calves ( [formula omitted][formula omitted]) derived from in vitro-generated embryos and transferred interspecifically into domestic cattle ( [formula omitted][formula omitted])</title><title>Theriogenology</title><addtitle>Theriogenology</addtitle><description>Advanced reproductive technologies, including IVF and interspecies embryo transfer, are becoming increasingly important for the preservation of endangered species. Previous attempts at interspecies transfer between
Bos
gaurus
and
bos
taurus
have yielded compromised offspring. The goal of this investigation was to characterize the effects of interspecies transfer of IVF-derived embryos on subsequent neonatal outcome. To achieve this goal, fresh
Bos
gaurus
IVF-derived embryos were transferred into Holstein (
Bos
taurus
) recipients. Four fetuses were carried to term. Calf weight, temperature, heart rate, and respiration rate were recorded after birth. Blood samples also were obtained for determination of blood glucose, pH, packed cell volume (PCV), total hemoglobin (tHB), Po
2, and Pco
2. After parturition, milk production and health status of the recipients were recorded. Two calves were alive at birth, and two calves were stillborn. One of the calves that was born alive died within minutes after birth, while the other lived until approximately 26 h of age. Blood samples obtained from the calf that lived for 26 h showed it to be extremely acidotic and hypoglycemic; this calf also had marked difficulty thermoregulating. At necrospy, all calves showed evidence of in utero gasping and hypoxia, suggestive of premature placental separation. None of the recipient cows showed typical signs of impending parturition. After parturition, lactogenesis in all recipient cows was markedly decreased. On gross examination, placentae resulting from the interespecies transfers had fewer cotyledons that were also much larger in size compared to cotyledons from normal gaur placetae. Calves in this study had abnormalities consistent with those noted from previous interspecies transfers and with IVF and nuclear transfer (cloned) calves. Due to the design of this study, it is not possible to differentiate between problems resulting from the IVF process and those resulting from potential interspecies incompatibilities. However, interspecies transfers of in vitro-produced gaur embryos into
Bos
taurus
are strongly discouraged.</description><subject>Acidosis - veterinary</subject><subject>Animals</subject><subject>Cattle - embryology</subject><subject>Cattle Diseases - pathology</subject><subject>embryo transfer</subject><subject>Embryo Transfer - veterinary</subject><subject>Female</subject><subject>Fertilization in Vitro - veterinary</subject><subject>Fetal Death - veterinary</subject><subject>Fetal Hypoxia - pathology</subject><subject>Fetal Hypoxia - veterinary</subject><subject>Hypoglycemia - veterinary</subject><subject>in-vitro fertilization</subject><subject>Lactation</subject><subject>Male</subject><subject>neonatal development</subject><subject>Placenta - pathology</subject><subject>Pregnancy</subject><subject>Species Specificity</subject><issn>0093-691X</issn><issn>1879-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-KFDEQxoMo7rj6CEpOsntorZp0dzonkcF_sOBBBUEkZJKKRLo7Y5JpmHf0oczsDHrwoKeQ4vdVfVUfY48RniFg__wDgBJNr_DzFeA1QFt_6g5b4SBVI9YC77LVb-SCPcj5OwCIvsf77AJRdK2EbsV-buK0S3EKmRx3tNAYdxPNhUfPrRkXyvyKf_ExTfvR8MqVQu7rX4Xrqk1hqT18bcbDzJdQUmy-0UzJVILTtE2HmLmZHS_JzNlTSrUe5kIp78gGH-rA8XCsRO7iRLkEW02UMtL_mXjI7nkzZnp0fi_Zp9evPm7eNjfv37zbvLxprOixNAa3khR4hUL6db8FN6xVb0C2su28coOHbt310qMVMAglDVJr1tgNQ9eSdeKSPT31rZf7sa8-db2fpXE0M8V91hKGKpeigt0JtCnmnMjrXQqTSQeNoI8x6tsY9TEjDahvY9Sq6p6cB-y3E7k_qnNuFXhxAqiuuQRKOttAsyUXEtmiXQz_GPELIVey8A</recordid><startdate>20010415</startdate><enddate>20010415</enddate><creator>Hammer, C.J.</creator><creator>Tyler, H.D.</creator><creator>Loskutoff, N.M.</creator><creator>Armstrong, D.L.</creator><creator>Funk, D.J.</creator><creator>Lindsey, B.R.</creator><creator>Simmons, L.G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010415</creationdate><title>Compromised development of calves ( [formula omitted][formula omitted]) derived from in vitro-generated embryos and transferred interspecifically into domestic cattle ( [formula omitted][formula omitted])</title><author>Hammer, C.J. ; Tyler, H.D. ; Loskutoff, N.M. ; Armstrong, D.L. ; Funk, D.J. ; Lindsey, B.R. ; Simmons, L.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-a1b7e90f9137f26b0d8296a074745f9d8f052567f1c308397a1e4a2158854ecd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acidosis - veterinary</topic><topic>Animals</topic><topic>Cattle - embryology</topic><topic>Cattle Diseases - pathology</topic><topic>embryo transfer</topic><topic>Embryo Transfer - veterinary</topic><topic>Female</topic><topic>Fertilization in Vitro - veterinary</topic><topic>Fetal Death - veterinary</topic><topic>Fetal Hypoxia - pathology</topic><topic>Fetal Hypoxia - veterinary</topic><topic>Hypoglycemia - veterinary</topic><topic>in-vitro fertilization</topic><topic>Lactation</topic><topic>Male</topic><topic>neonatal development</topic><topic>Placenta - pathology</topic><topic>Pregnancy</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammer, C.J.</creatorcontrib><creatorcontrib>Tyler, H.D.</creatorcontrib><creatorcontrib>Loskutoff, N.M.</creatorcontrib><creatorcontrib>Armstrong, D.L.</creatorcontrib><creatorcontrib>Funk, D.J.</creatorcontrib><creatorcontrib>Lindsey, B.R.</creatorcontrib><creatorcontrib>Simmons, L.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Theriogenology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammer, C.J.</au><au>Tyler, H.D.</au><au>Loskutoff, N.M.</au><au>Armstrong, D.L.</au><au>Funk, D.J.</au><au>Lindsey, B.R.</au><au>Simmons, L.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compromised development of calves ( [formula omitted][formula omitted]) derived from in vitro-generated embryos and transferred interspecifically into domestic cattle ( [formula omitted][formula omitted])</atitle><jtitle>Theriogenology</jtitle><addtitle>Theriogenology</addtitle><date>2001-04-15</date><risdate>2001</risdate><volume>55</volume><issue>7</issue><spage>1447</spage><epage>1455</epage><pages>1447-1455</pages><issn>0093-691X</issn><eissn>1879-3231</eissn><abstract>Advanced reproductive technologies, including IVF and interspecies embryo transfer, are becoming increasingly important for the preservation of endangered species. Previous attempts at interspecies transfer between
Bos
gaurus
and
bos
taurus
have yielded compromised offspring. The goal of this investigation was to characterize the effects of interspecies transfer of IVF-derived embryos on subsequent neonatal outcome. To achieve this goal, fresh
Bos
gaurus
IVF-derived embryos were transferred into Holstein (
Bos
taurus
) recipients. Four fetuses were carried to term. Calf weight, temperature, heart rate, and respiration rate were recorded after birth. Blood samples also were obtained for determination of blood glucose, pH, packed cell volume (PCV), total hemoglobin (tHB), Po
2, and Pco
2. After parturition, milk production and health status of the recipients were recorded. Two calves were alive at birth, and two calves were stillborn. One of the calves that was born alive died within minutes after birth, while the other lived until approximately 26 h of age. Blood samples obtained from the calf that lived for 26 h showed it to be extremely acidotic and hypoglycemic; this calf also had marked difficulty thermoregulating. At necrospy, all calves showed evidence of in utero gasping and hypoxia, suggestive of premature placental separation. None of the recipient cows showed typical signs of impending parturition. After parturition, lactogenesis in all recipient cows was markedly decreased. On gross examination, placentae resulting from the interespecies transfers had fewer cotyledons that were also much larger in size compared to cotyledons from normal gaur placetae. Calves in this study had abnormalities consistent with those noted from previous interspecies transfers and with IVF and nuclear transfer (cloned) calves. Due to the design of this study, it is not possible to differentiate between problems resulting from the IVF process and those resulting from potential interspecies incompatibilities. However, interspecies transfers of in vitro-produced gaur embryos into
Bos
taurus
are strongly discouraged.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11354705</pmid><doi>10.1016/S0093-691X(01)00493-9</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0093-691X |
| ispartof | Theriogenology, 2001-04, Vol.55 (7), p.1447-1455 |
| issn | 0093-691X 1879-3231 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70856773 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acidosis - veterinary Animals Cattle - embryology Cattle Diseases - pathology embryo transfer Embryo Transfer - veterinary Female Fertilization in Vitro - veterinary Fetal Death - veterinary Fetal Hypoxia - pathology Fetal Hypoxia - veterinary Hypoglycemia - veterinary in-vitro fertilization Lactation Male neonatal development Placenta - pathology Pregnancy Species Specificity |
| title | Compromised development of calves ( [formula omitted][formula omitted]) derived from in vitro-generated embryos and transferred interspecifically into domestic cattle ( [formula omitted][formula omitted]) |
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