Perilipin Ablation Results in a Lean Mouse with Aberrant Adipocyte Lipolysis, Enhanced Leptin Production, and Resistance to Diet-Induced Obesity

Perilipin coats the lipid droplets of adipocytes and is thought to have a role in regulating triacylglycerol hydrolysis. To study the role of perilipin in vivo, we have created a perilipin knockout mouse. Perilipin null (peri-/-) and wild-type (peri+/+) mice consume equal amounts of food, but the ad...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2001-05, Vol.98 (11), p.6494-6499
Hauptverfasser: Tansey, J. T., Sztalryd, C., Gruia-Gray, J., Roush, D. L., Zee, J. V., Gavrilova, O., Reitman, M. L., C.-X. Deng, Li, C., Kimmel, A. R., Londos, C.
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Sprache:eng
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