Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire
CD56, an adhesion molecule closely related to neural cell adhesion molecule, is an immunophenotypic marker for several unique populations of PBLS: Although CD56(+) cells derive from multiple lymphocyte lineages, they share a role in immunosurveillance and antitumor responses. We have studied the che...
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| Veröffentlicht in: | The Journal of immunology (1950) 2001-06, Vol.166 (11), p.6477-6482 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 166 |
| creator | Campbell, James J Qin, Shixin Unutmaz, Derya Soler, Dulce Murphy, Kristine E Hodge, Martin R Wu, Lijun Butcher, Eugene C |
| description | CD56, an adhesion molecule closely related to neural cell adhesion molecule, is an immunophenotypic marker for several unique populations of PBLS: Although CD56(+) cells derive from multiple lymphocyte lineages, they share a role in immunosurveillance and antitumor responses. We have studied the chemokine receptor expression patterns and functional migratory responses of three distinct CD56(+) populations from human peripheral blood. NK-T cells were found to differ greatly from NK cells, and CD16(+) NK cells from CD16(-) NK cells. CD16(+) NK cells were the predominant population responding to IL-8 and fractalkine, whereas NK-T cells were the predominant population responding to the CCR5 ligand macrophage-inflammatory protein-1beta. CD16(-) NK cells were the only CD56(+) population that uniformly expressed trafficking molecules necessary for homing into secondary lymphoid organs through high endothelial venule. These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types. |
| doi_str_mv | 10.4049/jimmunol.166.11.6477 |
| format | Article |
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We have studied the chemokine receptor expression patterns and functional migratory responses of three distinct CD56(+) populations from human peripheral blood. NK-T cells were found to differ greatly from NK cells, and CD16(+) NK cells from CD16(-) NK cells. CD16(+) NK cells were the predominant population responding to IL-8 and fractalkine, whereas NK-T cells were the predominant population responding to the CCR5 ligand macrophage-inflammatory protein-1beta. CD16(-) NK cells were the only CD56(+) population that uniformly expressed trafficking molecules necessary for homing into secondary lymphoid organs through high endothelial venule. These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.166.11.6477</identifier><identifier>PMID: 11359797</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Adult ; CD56 Antigen - biosynthesis ; CD56 Antigen - blood ; Cell Movement - immunology ; Chemokines - blood ; Chemokines - physiology ; Chemotaxis, Leukocyte - immunology ; Humans ; Immunophenotyping ; Killer Cells, Natural - metabolism ; Killer Cells, Natural - physiology ; Lymphoid Tissue - cytology ; Lymphoid Tissue - immunology ; Organ Specificity - immunology ; Receptors, Chemokine - biosynthesis ; Receptors, Chemokine - blood ; Receptors, IgG - biosynthesis ; Receptors, IgG - immunology ; T-Lymphocyte Subsets - metabolism ; T-Lymphocyte Subsets - physiology</subject><ispartof>The Journal of immunology (1950), 2001-06, Vol.166 (11), p.6477-6482</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-286c4ffebe39e6ff4e2ed81b79e12caf321bafb489cf00f7a82855f2e042b4ed3</citedby><cites>FETCH-LOGICAL-c382t-286c4ffebe39e6ff4e2ed81b79e12caf321bafb489cf00f7a82855f2e042b4ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11359797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campbell, James J</creatorcontrib><creatorcontrib>Qin, Shixin</creatorcontrib><creatorcontrib>Unutmaz, Derya</creatorcontrib><creatorcontrib>Soler, Dulce</creatorcontrib><creatorcontrib>Murphy, Kristine E</creatorcontrib><creatorcontrib>Hodge, Martin R</creatorcontrib><creatorcontrib>Wu, Lijun</creatorcontrib><creatorcontrib>Butcher, Eugene C</creatorcontrib><title>Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>CD56, an adhesion molecule closely related to neural cell adhesion molecule, is an immunophenotypic marker for several unique populations of PBLS: Although CD56(+) cells derive from multiple lymphocyte lineages, they share a role in immunosurveillance and antitumor responses. We have studied the chemokine receptor expression patterns and functional migratory responses of three distinct CD56(+) populations from human peripheral blood. NK-T cells were found to differ greatly from NK cells, and CD16(+) NK cells from CD16(-) NK cells. CD16(+) NK cells were the predominant population responding to IL-8 and fractalkine, whereas NK-T cells were the predominant population responding to the CCR5 ligand macrophage-inflammatory protein-1beta. CD16(-) NK cells were the only CD56(+) population that uniformly expressed trafficking molecules necessary for homing into secondary lymphoid organs through high endothelial venule. These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types.</description><subject>Adult</subject><subject>CD56 Antigen - biosynthesis</subject><subject>CD56 Antigen - blood</subject><subject>Cell Movement - immunology</subject><subject>Chemokines - blood</subject><subject>Chemokines - physiology</subject><subject>Chemotaxis, Leukocyte - immunology</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Killer Cells, Natural - physiology</subject><subject>Lymphoid Tissue - cytology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Organ Specificity - immunology</subject><subject>Receptors, Chemokine - biosynthesis</subject><subject>Receptors, Chemokine - blood</subject><subject>Receptors, IgG - biosynthesis</subject><subject>Receptors, IgG - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>T-Lymphocyte Subsets - physiology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMFu1DAURS0EokPLHyDkFaqEMtiOYydLmLZQMYIK2rXlJM_ExYmNnWiYDd9eVzMIVld6OvdK7yD0ipI1J7x5d2_HcZm8W1Mh1pSuBZfyCVrRqiKFEEQ8RStCGCuoFPIEvUjpnhAiCOPP0QmlZdXIRq7Qn7vJ_loAf1_a4MPi9Gz9lLA3eHNRibf4y2espz5HcYtvINowQNQOf3De93i7H8Pgu_0MCV_3MM3WWOhxu8ebAUb_006Av0EHYfYRX_4OEVLK8_kWIM7eRjhDz4x2CV4e8xTdXV3ebj4V268frzfvt0VX1mwuWC06bgy0UDYgjOHAoK9pKxugrNOmZLTVpuV10xlCjNQ1q6vKMCCctRz68hS9OeyG6PO7aVajTR04pyfwS1KS1FUpmzqD_AB20acUwagQ7ajjXlGiHr2rv95V9q4oVY_ec-31cX9pR-j_lY6iM3B-AAb7Y9jlz1UatXMZp2q32_2_9QANRZD9</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Campbell, James J</creator><creator>Qin, Shixin</creator><creator>Unutmaz, Derya</creator><creator>Soler, Dulce</creator><creator>Murphy, Kristine E</creator><creator>Hodge, Martin R</creator><creator>Wu, Lijun</creator><creator>Butcher, Eugene C</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire</title><author>Campbell, James J ; Qin, Shixin ; Unutmaz, Derya ; Soler, Dulce ; Murphy, Kristine E ; Hodge, Martin R ; Wu, Lijun ; Butcher, Eugene C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-286c4ffebe39e6ff4e2ed81b79e12caf321bafb489cf00f7a82855f2e042b4ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>CD56 Antigen - biosynthesis</topic><topic>CD56 Antigen - blood</topic><topic>Cell Movement - immunology</topic><topic>Chemokines - blood</topic><topic>Chemokines - physiology</topic><topic>Chemotaxis, Leukocyte - immunology</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Killer Cells, Natural - physiology</topic><topic>Lymphoid Tissue - cytology</topic><topic>Lymphoid Tissue - immunology</topic><topic>Organ Specificity - immunology</topic><topic>Receptors, Chemokine - biosynthesis</topic><topic>Receptors, Chemokine - blood</topic><topic>Receptors, IgG - biosynthesis</topic><topic>Receptors, IgG - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>T-Lymphocyte Subsets - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campbell, James J</creatorcontrib><creatorcontrib>Qin, Shixin</creatorcontrib><creatorcontrib>Unutmaz, Derya</creatorcontrib><creatorcontrib>Soler, Dulce</creatorcontrib><creatorcontrib>Murphy, Kristine E</creatorcontrib><creatorcontrib>Hodge, Martin R</creatorcontrib><creatorcontrib>Wu, Lijun</creatorcontrib><creatorcontrib>Butcher, Eugene C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campbell, James J</au><au>Qin, Shixin</au><au>Unutmaz, Derya</au><au>Soler, Dulce</au><au>Murphy, Kristine E</au><au>Hodge, Martin R</au><au>Wu, Lijun</au><au>Butcher, Eugene C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>166</volume><issue>11</issue><spage>6477</spage><epage>6482</epage><pages>6477-6482</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>CD56, an adhesion molecule closely related to neural cell adhesion molecule, is an immunophenotypic marker for several unique populations of PBLS: Although CD56(+) cells derive from multiple lymphocyte lineages, they share a role in immunosurveillance and antitumor responses. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult CD56 Antigen - biosynthesis CD56 Antigen - blood Cell Movement - immunology Chemokines - blood Chemokines - physiology Chemotaxis, Leukocyte - immunology Humans Immunophenotyping Killer Cells, Natural - metabolism Killer Cells, Natural - physiology Lymphoid Tissue - cytology Lymphoid Tissue - immunology Organ Specificity - immunology Receptors, Chemokine - biosynthesis Receptors, Chemokine - blood Receptors, IgG - biosynthesis Receptors, IgG - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - physiology |
| title | Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire |
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