Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice
Atherosclerosis involves inflammatory processes between vasculartissues and hematocytes with a hyperlipidemic background. To examinewhether variations of hematocytes constitute one of the geneticcomponents in atherosclerosis, irradiated apolipoprotein E(apoE)‐deficient (apoE−/−) mice with hyperchole...
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| Veröffentlicht in: | Journal of leukocyte biology 2001-05, Vol.69 (5), p.732-740 |
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| creator | Ishimori, Naoki Iwabuchi, Kazuya Fujii, Satoshi Watano, Keiko Iwabuchi, Chikako Ato, Manabu Chiba, Hitoshi Tanaka, Shinya Kitabatake, Akira Onoé, Kazunori |
| description | Atherosclerosis involves inflammatory processes between vasculartissues and hematocytes with a hyperlipidemic background. To examinewhether variations of hematocytes constitute one of the geneticcomponents in atherosclerosis, irradiated apolipoprotein E(apoE)‐deficient (apoE−/−) mice with hypercholesterolemiaand preexisting atherosclerotic lesions were reconstituted withmixed bone marrow cells (BMC) from syngeneic and wild‐type(apoE+/+; atherosclerosis‐resistant SJL or ‐susceptibleB10.S) mice. Stable mixed allogeneic chimeras with small amounts ofserum apoE were established without any detrimentalcomplications. Compared with untreated apoE−/− miceor apoE−/− mice transplanted with syngeneic BMC alone, significant reduction of the cholesterol level and significant lesionregression were observed in the mixed chimeras. Furthermore, mixedchimeras given SJL BMC showed marked reductions in numbers of lesionscompared with those reconstituted with B10.S BMC. Cholesterol levels inthe former SJL chimeras, however, were significantly higher than thosein the latter B10.S chimeras. These findings indicate that theresistance of SJL to atherosclerosis resides in the bone marrow‐derivedcells. |
| doi_str_mv | 10.1189/jlb.69.5.732 |
| format | Article |
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To examinewhether variations of hematocytes constitute one of the geneticcomponents in atherosclerosis, irradiated apolipoprotein E(apoE)‐deficient (apoE−/−) mice with hypercholesterolemiaand preexisting atherosclerotic lesions were reconstituted withmixed bone marrow cells (BMC) from syngeneic and wild‐type(apoE+/+; atherosclerosis‐resistant SJL or ‐susceptibleB10.S) mice. Stable mixed allogeneic chimeras with small amounts ofserum apoE were established without any detrimentalcomplications. Compared with untreated apoE−/− miceor apoE−/− mice transplanted with syngeneic BMC alone, significant reduction of the cholesterol level and significant lesionregression were observed in the mixed chimeras. Furthermore, mixedchimeras given SJL BMC showed marked reductions in numbers of lesionscompared with those reconstituted with B10.S BMC. Cholesterol levels inthe former SJL chimeras, however, were significantly higher than thosein the latter B10.S chimeras. These findings indicate that theresistance of SJL to atherosclerosis resides in the bone marrow‐derivedcells.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1189/jlb.69.5.732</identifier><identifier>PMID: 11358981</identifier><language>eng</language><publisher>United States: Society for Leukocyte Biology</publisher><subject>Animals ; apolipoprotein E ; Apolipoproteins E - immunology ; Arteriosclerosis - blood ; Arteriosclerosis - immunology ; Arteriosclerosis - pathology ; Bone Marrow Cells - immunology ; bone marrow transplantation ; Bone Marrow Transplantation - immunology ; bone marrow‐derived cell ; cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Female ; gene transfer ; hypercholesterolemia ; Hypercholesterolemia - blood ; Hypercholesterolemia - immunology ; Hypercholesterolemia - pathology ; inbred strains ; macrophage ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Transplantation Chimera - blood ; Transplantation Chimera - immunology ; Triglycerides - blood</subject><ispartof>Journal of leukocyte biology, 2001-05, Vol.69 (5), p.732-740</ispartof><rights>2001 Society for Leukocyte Biology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3902-1786dc18f809dbe1327a93573eb7cb8132ceb949ff2d8a39f20d68523d0f94af3</citedby><cites>FETCH-LOGICAL-c3902-1786dc18f809dbe1327a93573eb7cb8132ceb949ff2d8a39f20d68523d0f94af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1189%2Fjlb.69.5.732$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1189%2Fjlb.69.5.732$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11358981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishimori, Naoki</creatorcontrib><creatorcontrib>Iwabuchi, Kazuya</creatorcontrib><creatorcontrib>Fujii, Satoshi</creatorcontrib><creatorcontrib>Watano, Keiko</creatorcontrib><creatorcontrib>Iwabuchi, Chikako</creatorcontrib><creatorcontrib>Ato, Manabu</creatorcontrib><creatorcontrib>Chiba, Hitoshi</creatorcontrib><creatorcontrib>Tanaka, Shinya</creatorcontrib><creatorcontrib>Kitabatake, Akira</creatorcontrib><creatorcontrib>Onoé, Kazunori</creatorcontrib><title>Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>Atherosclerosis involves inflammatory processes between vasculartissues and hematocytes with a hyperlipidemic background. To examinewhether variations of hematocytes constitute one of the geneticcomponents in atherosclerosis, irradiated apolipoprotein E(apoE)‐deficient (apoE−/−) mice with hypercholesterolemiaand preexisting atherosclerotic lesions were reconstituted withmixed bone marrow cells (BMC) from syngeneic and wild‐type(apoE+/+; atherosclerosis‐resistant SJL or ‐susceptibleB10.S) mice. Stable mixed allogeneic chimeras with small amounts ofserum apoE were established without any detrimentalcomplications. Compared with untreated apoE−/− miceor apoE−/− mice transplanted with syngeneic BMC alone, significant reduction of the cholesterol level and significant lesionregression were observed in the mixed chimeras. Furthermore, mixedchimeras given SJL BMC showed marked reductions in numbers of lesionscompared with those reconstituted with B10.S BMC. Cholesterol levels inthe former SJL chimeras, however, were significantly higher than thosein the latter B10.S chimeras. These findings indicate that theresistance of SJL to atherosclerosis resides in the bone marrow‐derivedcells.</description><subject>Animals</subject><subject>apolipoprotein E</subject><subject>Apolipoproteins E - immunology</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - immunology</subject><subject>Arteriosclerosis - pathology</subject><subject>Bone Marrow Cells - immunology</subject><subject>bone marrow transplantation</subject><subject>Bone Marrow Transplantation - immunology</subject><subject>bone marrow‐derived cell</subject><subject>cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Female</subject><subject>gene transfer</subject><subject>hypercholesterolemia</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - immunology</subject><subject>Hypercholesterolemia - pathology</subject><subject>inbred strains</subject><subject>macrophage</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Transplantation Chimera - blood</subject><subject>Transplantation Chimera - immunology</subject><subject>Triglycerides - blood</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctv3CAQxlHVqtlue8s58qU51VswfsAxidKXtuqlPSMMQzwRfgS8cva_L5FX6S29DIz045vh-wg5Z3THmJCf7327q-Wu2jW8eEU2THKR87rhr8mGNiXLq5LSM_IuxntKKS9q-pacMcYrIQXbkOknPoLNtPfjHQyAJjMd9hAw9tmCc5eKt_l8nCCLc9A4xEz34HEMeoZ0nzsIYzT-qWLMcMj0NHqcximMM6T2Nrfg0CAMc9ajgffkjdM-wofTuSV_vtz-vvmW7399_X5ztc8Nl7TIWSNqa5hwgkrbAuNFoyWvGg5tY1qRegOtLKVzhRWaS1dQW4uq4JY6WWrHt-Ry1U2LPBwgzqrHaMB7PcB4iKqhouJ1Sf8Lpk1EVSfHtuTTCpr01xjAqSlgr8NRMaqeolApClVLVakURcIvTrqHtgf7Dz55nwC2AsliOL4opn7sr-kq-nF90-Fdt2AAFfuUXRpRqGVZnof_BcF6o3I</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Ishimori, Naoki</creator><creator>Iwabuchi, Kazuya</creator><creator>Fujii, Satoshi</creator><creator>Watano, Keiko</creator><creator>Iwabuchi, Chikako</creator><creator>Ato, Manabu</creator><creator>Chiba, Hitoshi</creator><creator>Tanaka, Shinya</creator><creator>Kitabatake, Akira</creator><creator>Onoé, Kazunori</creator><general>Society for Leukocyte Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200105</creationdate><title>Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice</title><author>Ishimori, Naoki ; Iwabuchi, Kazuya ; Fujii, Satoshi ; Watano, Keiko ; Iwabuchi, Chikako ; Ato, Manabu ; Chiba, Hitoshi ; Tanaka, Shinya ; Kitabatake, Akira ; Onoé, Kazunori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3902-1786dc18f809dbe1327a93573eb7cb8132ceb949ff2d8a39f20d68523d0f94af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>apolipoprotein E</topic><topic>Apolipoproteins E - immunology</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - immunology</topic><topic>Arteriosclerosis - pathology</topic><topic>Bone Marrow Cells - immunology</topic><topic>bone marrow transplantation</topic><topic>Bone Marrow Transplantation - immunology</topic><topic>bone marrow‐derived cell</topic><topic>cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Female</topic><topic>gene transfer</topic><topic>hypercholesterolemia</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - immunology</topic><topic>Hypercholesterolemia - pathology</topic><topic>inbred strains</topic><topic>macrophage</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Transplantation Chimera - blood</topic><topic>Transplantation Chimera - immunology</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishimori, Naoki</creatorcontrib><creatorcontrib>Iwabuchi, Kazuya</creatorcontrib><creatorcontrib>Fujii, Satoshi</creatorcontrib><creatorcontrib>Watano, Keiko</creatorcontrib><creatorcontrib>Iwabuchi, Chikako</creatorcontrib><creatorcontrib>Ato, Manabu</creatorcontrib><creatorcontrib>Chiba, Hitoshi</creatorcontrib><creatorcontrib>Tanaka, Shinya</creatorcontrib><creatorcontrib>Kitabatake, Akira</creatorcontrib><creatorcontrib>Onoé, Kazunori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishimori, Naoki</au><au>Iwabuchi, Kazuya</au><au>Fujii, Satoshi</au><au>Watano, Keiko</au><au>Iwabuchi, Chikako</au><au>Ato, Manabu</au><au>Chiba, Hitoshi</au><au>Tanaka, Shinya</au><au>Kitabatake, Akira</au><au>Onoé, Kazunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2001-05</date><risdate>2001</risdate><volume>69</volume><issue>5</issue><spage>732</spage><epage>740</epage><pages>732-740</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>Atherosclerosis involves inflammatory processes between vasculartissues and hematocytes with a hyperlipidemic background. To examinewhether variations of hematocytes constitute one of the geneticcomponents in atherosclerosis, irradiated apolipoprotein E(apoE)‐deficient (apoE−/−) mice with hypercholesterolemiaand preexisting atherosclerotic lesions were reconstituted withmixed bone marrow cells (BMC) from syngeneic and wild‐type(apoE+/+; atherosclerosis‐resistant SJL or ‐susceptibleB10.S) mice. Stable mixed allogeneic chimeras with small amounts ofserum apoE were established without any detrimentalcomplications. Compared with untreated apoE−/− miceor apoE−/− mice transplanted with syngeneic BMC alone, significant reduction of the cholesterol level and significant lesionregression were observed in the mixed chimeras. Furthermore, mixedchimeras given SJL BMC showed marked reductions in numbers of lesionscompared with those reconstituted with B10.S BMC. Cholesterol levels inthe former SJL chimeras, however, were significantly higher than thosein the latter B10.S chimeras. These findings indicate that theresistance of SJL to atherosclerosis resides in the bone marrow‐derivedcells.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>11358981</pmid><doi>10.1189/jlb.69.5.732</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of leukocyte biology, 2001-05, Vol.69 (5), p.732-740 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals apolipoprotein E Apolipoproteins E - immunology Arteriosclerosis - blood Arteriosclerosis - immunology Arteriosclerosis - pathology Bone Marrow Cells - immunology bone marrow transplantation Bone Marrow Transplantation - immunology bone marrow‐derived cell cholesterol Cholesterol - blood Cholesterol, HDL - blood Female gene transfer hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - immunology Hypercholesterolemia - pathology inbred strains macrophage Mice Mice, Inbred C57BL Mice, Knockout Transplantation Chimera - blood Transplantation Chimera - immunology Triglycerides - blood |
| title | Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice |
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