Structure of the Unliganded cAMP-Dependent Protein Kinase Catalytic Subunit from Saccharomyces cerevisiae

The structure of TPK1Δ, a truncated variant of the cAMP-dependent protein kinase catalytic subunit from Saccharomyces cerevisiae, was determined in an unliganded state at 2.8 Å resolution and refined to a crystallographic R-factor of 19.4%. Comparison of this structure to that of its fully liganded...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2001-03, Vol.387 (1), p.11-19
Hauptverfasser:	Mashhoon, Neda, Carmel, Gilles, Pflugrath, James W., Kuret, Jeff
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Catalysis Catalytic Domain Crystallography, X-Ray Cyclic AMP-Dependent Protein Kinases - chemistry Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Evolution, Molecular Ligands Models, Molecular Molecular Sequence Data Mutation Peptide Fragments Protein Conformation protein kinase protein structure Protein Subunits Saccharomyces cerevisiae - enzymology Sequence Deletion Sequence Homology, Amino Acid Species Specificity Substrate Specificity X-ray crystallography
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