Development of new urea-functionalized silica stationary phases: Characterization and chromatographic performance
New urea-functionalized silica stationary phases were prepared by a single-step surface modification through reaction of LiChrosorb Si100 (5 μm particle size) with a homologous series of alkoxysilanes, synthesized in our laboratory, with the general formula (CH 3CH 2O) 3Si(CH 2) 3NHC(O)NH(CH 2) n CH...
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| Veröffentlicht in: | Journal of Chromatography A 2001-04, Vol.913 (1), p.65-73 |
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| creator | Silva, Cesar Ricardo Jardim, Isabel Cristina Sales Fontes Airoldi, Claudio |
| description | New urea-functionalized silica stationary phases were prepared by a single-step surface modification through reaction of LiChrosorb Si100 (5 μm particle size) with a homologous series of alkoxysilanes, synthesized in our laboratory, with the general formula (CH
3CH
2O)
3Si(CH
2)
3NHC(O)NH(CH
2)
n
CH
3, where
n=4, 6 and 11. The modified silicas were characterized by elemental analysis of carbon and nitrogen, solid-state
29Si- and
13C-cross polarization magic angle spinning nuclear magnetic resonance and nitrogen adsorption isotherms at 77 K. Chromatographic evaluation of the three urea-functionalized silicas in 150×3.9 mm I.D. HPLC columns was carried out by the separation of a test mixture composed of uracil, acetophenone, benzene, toluene and naphthalene, using acetonitrile–water as mobile phase. These new stationary phases, with embedded polar urea groups, are very promising when compared with amide phases prepared by the conventional two-step modification process. A single-step reaction process silica modification is better for obtaining a well-characterized and homogeneous modified surface. |
| doi_str_mv | 10.1016/S0021-9673(00)01028-1 |
| format | Article |
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3CH
2O)
3Si(CH
2)
3NHC(O)NH(CH
2)
n
CH
3, where
n=4, 6 and 11. The modified silicas were characterized by elemental analysis of carbon and nitrogen, solid-state
29Si- and
13C-cross polarization magic angle spinning nuclear magnetic resonance and nitrogen adsorption isotherms at 77 K. Chromatographic evaluation of the three urea-functionalized silicas in 150×3.9 mm I.D. HPLC columns was carried out by the separation of a test mixture composed of uracil, acetophenone, benzene, toluene and naphthalene, using acetonitrile–water as mobile phase. These new stationary phases, with embedded polar urea groups, are very promising when compared with amide phases prepared by the conventional two-step modification process. A single-step reaction process silica modification is better for obtaining a well-characterized and homogeneous modified surface.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/S0021-9673(00)01028-1</identifier><identifier>PMID: 11355845</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analytical chemistry ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, High Pressure Liquid - instrumentation ; Exact sciences and technology ; Magnetic Resonance Spectroscopy ; Other chromatographic methods ; Silicon Dioxide - chemistry ; Urea - chemistry</subject><ispartof>Journal of Chromatography A, 2001-04, Vol.913 (1), p.65-73</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0021-9673(00)01028-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,23929,23930,25139,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=962681$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11355845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Cesar Ricardo</creatorcontrib><creatorcontrib>Jardim, Isabel Cristina Sales Fontes</creatorcontrib><creatorcontrib>Airoldi, Claudio</creatorcontrib><title>Development of new urea-functionalized silica stationary phases: Characterization and chromatographic performance</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>New urea-functionalized silica stationary phases were prepared by a single-step surface modification through reaction of LiChrosorb Si100 (5 μm particle size) with a homologous series of alkoxysilanes, synthesized in our laboratory, with the general formula (CH
3CH
2O)
3Si(CH
2)
3NHC(O)NH(CH
2)
n
CH
3, where
n=4, 6 and 11. The modified silicas were characterized by elemental analysis of carbon and nitrogen, solid-state
29Si- and
13C-cross polarization magic angle spinning nuclear magnetic resonance and nitrogen adsorption isotherms at 77 K. Chromatographic evaluation of the three urea-functionalized silicas in 150×3.9 mm I.D. HPLC columns was carried out by the separation of a test mixture composed of uracil, acetophenone, benzene, toluene and naphthalene, using acetonitrile–water as mobile phase. These new stationary phases, with embedded polar urea groups, are very promising when compared with amide phases prepared by the conventional two-step modification process. A single-step reaction process silica modification is better for obtaining a well-characterized and homogeneous modified surface.</description><subject>Analytical chemistry</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Exact sciences and technology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Other chromatographic methods</subject><subject>Silicon Dioxide - chemistry</subject><subject>Urea - chemistry</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtv2zAQhHlIUDtuf0IDAgGC5KBkKYp65BIETh8BDOSQ9kysqFXNQhJlUnJQ__rKjpPTArMfBpgZxr4KuBEg0tsXgFhERZrJK4BrEBDnkThh8w95xs5C-AsgMsjiT2wmhFQqT9ScbR5pS43rW-oG7mre0SsfPWFUj50ZrOuwsTuqeLCNNcjDgAfR_-P9GgOFO75co0czkLe7w49jV3Gz9q7Fwf3x2K-t4T352vkWO0Of2WmNTaAvx7tgv79_-7X8Ga2efzwtH1YRxYUYogSlKk2Wp0VWQiUVyUSRgcqAzGtJdVzKVCYAUCoScaFyIDAJprHJUpGrWi7Y5Ztv791mpDDo1gZDTYMduTHoDHIlYWpiwc6P4Fi2VOne23YKqN9LmoCLI4DBYFP7KYYNH1yRxmm-t7l_o2gKtbXkdTCWpsCV9WQGXTmrBej9YPowmN4vowH0YTAt5H_oGYq0</recordid><startdate>20010413</startdate><enddate>20010413</enddate><creator>Silva, Cesar Ricardo</creator><creator>Jardim, Isabel Cristina Sales Fontes</creator><creator>Airoldi, Claudio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20010413</creationdate><title>Development of new urea-functionalized silica stationary phases: Characterization and chromatographic performance</title><author>Silva, Cesar Ricardo ; Jardim, Isabel Cristina Sales Fontes ; Airoldi, Claudio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e291t-4a35bc78697b0d35e345ec0dc038f3ef2b3634000b5e129580e0c4a62c76185f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Analytical chemistry</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, High Pressure Liquid - instrumentation</topic><topic>Exact sciences and technology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Other chromatographic methods</topic><topic>Silicon Dioxide - chemistry</topic><topic>Urea - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Cesar Ricardo</creatorcontrib><creatorcontrib>Jardim, Isabel Cristina Sales Fontes</creatorcontrib><creatorcontrib>Airoldi, Claudio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Cesar Ricardo</au><au>Jardim, Isabel Cristina Sales Fontes</au><au>Airoldi, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of new urea-functionalized silica stationary phases: Characterization and chromatographic performance</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2001-04-13</date><risdate>2001</risdate><volume>913</volume><issue>1</issue><spage>65</spage><epage>73</epage><pages>65-73</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>New urea-functionalized silica stationary phases were prepared by a single-step surface modification through reaction of LiChrosorb Si100 (5 μm particle size) with a homologous series of alkoxysilanes, synthesized in our laboratory, with the general formula (CH
3CH
2O)
3Si(CH
2)
3NHC(O)NH(CH
2)
n
CH
3, where
n=4, 6 and 11. The modified silicas were characterized by elemental analysis of carbon and nitrogen, solid-state
29Si- and
13C-cross polarization magic angle spinning nuclear magnetic resonance and nitrogen adsorption isotherms at 77 K. Chromatographic evaluation of the three urea-functionalized silicas in 150×3.9 mm I.D. HPLC columns was carried out by the separation of a test mixture composed of uracil, acetophenone, benzene, toluene and naphthalene, using acetonitrile–water as mobile phase. These new stationary phases, with embedded polar urea groups, are very promising when compared with amide phases prepared by the conventional two-step modification process. A single-step reaction process silica modification is better for obtaining a well-characterized and homogeneous modified surface.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11355845</pmid><doi>10.1016/S0021-9673(00)01028-1</doi><tpages>9</tpages></addata></record> |
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| issn | 0021-9673 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - instrumentation Exact sciences and technology Magnetic Resonance Spectroscopy Other chromatographic methods Silicon Dioxide - chemistry Urea - chemistry |
| title | Development of new urea-functionalized silica stationary phases: Characterization and chromatographic performance |
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