Insulin Resistance: Cellular and Clinical Concepts
Insulin resistance is defined as a clinical state in which a normal or elevated insulin level produces an attenuated biologic response. Specifically, the biologic response most studied is insulin-stimulated glucose disposal, yet the precise cellular mechanism responsible is not yet known. However, t...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 2001-01, Vol.226 (1), p.13-26 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
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| creator | Cefalu, William T. |
| description | Insulin resistance is defined as a clinical state in which a normal or elevated insulin level produces an attenuated biologic response. Specifically, the biologic response most studied is insulin-stimulated glucose disposal, yet the precise cellular mechanism responsible is not yet known. However, the presence of insulin resistance is observed many years before the onset of clinical hyperglycemia and the diagnosis of Type 2 diabetes. Insulin resistance at this stage appears to be significantly associated with a clustering of cardiovascular risk factors predisposing the individual to accelerated cardiovascular disease. An overview of insulin resistance and the associated clinical insulin resistant state will be discussed. |
| doi_str_mv | 10.1177/153537020122600103 |
| format | Article |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 2001-01, Vol.226 (1), p.13-26 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological Transport Cardiovascular Diseases - etiology Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - prevention & control Glucose - metabolism Glycogen - biosynthesis Humans Hyperglycemia - etiology Hyperglycemia - prevention & control Insulin - blood Insulin - physiology Insulin Resistance Models, Chemical Signal Transduction Syndrome |
| title | Insulin Resistance: Cellular and Clinical Concepts |
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