Description of Japanese twins with cleft lip, cleft palate, or both
Cleft lip and palate is relatively common among congenital external malformations; however, the pathogenesis of this condition remains unclear. Cleft lip and palate has long been considered to be a multifactorial hereditary disease in which not only genetic factors, but also environmental factors, m...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2000-01, Vol.89 (1), p.6-8 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | Natsume, Nagato Sato, Fumihiko Hara, Kouji Kawai, Tsuyoshi Ogi, Nobumi |
| description | Cleft lip and palate is relatively common among congenital external malformations; however, the pathogenesis of this condition remains unclear. Cleft lip and palate has long been considered to be a multifactorial hereditary disease in which not only genetic factors, but also environmental factors, may be related in a complex manner. We have been studying the pathogenesis of cleft lip and palate in Japan and report here on some recent findings. We reviewed 32 pairs of Japanese monozygotic twins who had cleft lip and palate and compared these twins with non-twins who had cleft lip and palate in order to elucidate genetic factors that may cause this malformation. |
| doi_str_mv | 10.1016/S1079-2104(00)80004-9 |
| format | Article |
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Cleft lip and palate has long been considered to be a multifactorial hereditary disease in which not only genetic factors, but also environmental factors, may be related in a complex manner. We have been studying the pathogenesis of cleft lip and palate in Japan and report here on some recent findings. 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Cleft lip and palate has long been considered to be a multifactorial hereditary disease in which not only genetic factors, but also environmental factors, may be related in a complex manner. We have been studying the pathogenesis of cleft lip and palate in Japan and report here on some recent findings. We reviewed 32 pairs of Japanese monozygotic twins who had cleft lip and palate and compared these twins with non-twins who had cleft lip and palate in order to elucidate genetic factors that may cause this malformation.</description><subject>Biological and medical sciences</subject><subject>Cleft Lip - ethnology</subject><subject>Cleft Lip - genetics</subject><subject>Cleft Palate - ethnology</subject><subject>Cleft Palate - genetics</subject><subject>Dentistry</subject><subject>Diseases in Twins - ethnology</subject><subject>Diseases in Twins - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Twins, Monozygotic</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMofv8EpQcRBauTtNkmJ5H1G8GDCt5Cmk4w0m1rknXx3xvdFb15mvfwvDPDQ8gOhWMKdHTyQKGSOaNQHgAcCgAoc7lE1ilnIi8kf15O-QdZIxshvCZmVEi5StZoCiCLYp2MzzEY74bo-i7rbXarB91hwCzOXBeymYsvmWnRxqx1w9EiDrrVEY-y3md1H1-2yIrVbcDtxdwkT5cXj-Pr_O7-6mZ8dpebQkLMK2Zq2RjkUEHBG6wLtNxYYCXnpTY1swwaNhIjbIRppJW04jZRuqpEWfGy2CT7872D79-mGKKauGCwbdPH_TSoCgQHIUUC-Rw0vg_Bo1WDdxPtPxQF9WVPfdtTX2oUgPq2p2Tq7S4OTOsJNn9ac10J2FsAOhjdWq8748Ivx0pGBU_Y6RzDZOPdoVfBOOwMNs6jiarp3T-ffAK9e4qv</recordid><startdate>200001</startdate><enddate>200001</enddate><creator>Natsume, Nagato</creator><creator>Sato, Fumihiko</creator><creator>Hara, Kouji</creator><creator>Kawai, Tsuyoshi</creator><creator>Ogi, Nobumi</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200001</creationdate><title>Description of Japanese twins with cleft lip, cleft palate, or both</title><author>Natsume, Nagato ; Sato, Fumihiko ; Hara, Kouji ; Kawai, Tsuyoshi ; Ogi, Nobumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-72cb9dce507035deb3ef5cf024554acb2f20d2686ed8cd9f9175feb3a77847543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Cleft Lip - ethnology</topic><topic>Cleft Lip - genetics</topic><topic>Cleft Palate - ethnology</topic><topic>Cleft Palate - genetics</topic><topic>Dentistry</topic><topic>Diseases in Twins - ethnology</topic><topic>Diseases in Twins - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. 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| fulltext | fulltext |
| identifier | ISSN: 1079-2104 |
| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2000-01, Vol.89 (1), p.6-8 |
| issn | 1079-2104 1528-395X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70850898 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Cleft Lip - ethnology Cleft Lip - genetics Cleft Palate - ethnology Cleft Palate - genetics Dentistry Diseases in Twins - ethnology Diseases in Twins - genetics Female Humans Incidence Japan - epidemiology Male Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Twins, Monozygotic Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Description of Japanese twins with cleft lip, cleft palate, or both |
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