Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells

The modulation of garlic oil (GO) and three allyl compounds, diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS), on the antioxidation system in rat livers and red blood cells was examined. Rats were orally administered GO (200 mg/kg body weight), DAS (20, 80 mg/kg body wei...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Food and chemical toxicology 2001-06, Vol.39 (6), p.563-569
Hauptverfasser:	Wu, C.C, Sheen, L.Y, Chen, H.-W, Tsai, S.-J, Lii, C.-K
Format:	Artikel
Sprache:	eng
Schlagworte:	Allium sativum Allyl compounds Allyl Compounds - administration & dosage Allyl Compounds - pharmacology allyl sulfide Animals Anticarcinogenic Agents - pharmacology Antioxidants Antioxidation Biological and medical sciences Blotting, Western Body Weight - drug effects diallyl disulfide diallyl sulfide diallyl trisulfide Disulfides - pharmacology Electrophoresis, Polyacrylamide Gel Erythrocytes - drug effects Erythrocytes - enzymology Erythrocytes - metabolism Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Garlic oil Glutathione - metabolism Glutathione Disulfide - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism Hemolysis Lipid Peroxidation Liver - drug effects Liver - enzymology Liver - metabolism Male Oxidation-Reduction Rats Rats, Sprague-Dawley Sulfides - administration & dosage Sulfides - pharmacology Thiobarbituric Acid Reactive Substances - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The modulation of garlic oil (GO) and three allyl compounds, diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS), on the antioxidation system in rat livers and red blood cells was examined. Rats were orally administered GO (200 mg/kg body weight), DAS (20, 80 mg/kg body weight), DADS (80 mg/kg body weight) or DATS (70 mg/kg body weight) three times a week for 6 weeks. Control rats received corn oil (2 ml/kg body weight) alone. GO, DADS and DATS treatment significantly increased the glutathione (GSH) content (48–84%) in red blood cells ( P
ISSN:	0278-6915 1873-6351
DOI:	10.1016/S0278-6915(00)00171-X