Synthesis and deconvolution of the first combinatorial library of glycosidase inhibitors

A combinatorial library of 125 compounds with a structure consisting of 1-azafagomine linked at N-1 via an acetic acid linker to a variable tripeptide was synthesised. The library was synthesised by Merrifield split and mix synthesis of the peptide, followed by capping with chloroacetate, regioselec...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1999-09, Vol.7 (9), p.1965-1971
Hauptverfasser:	LOHSE, A, JENSEN, K. B, LUNDGREN, K, BOLS, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carbohydrate Sequence Combinatorial Chemistry Techniques Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General and cellular metabolism. Vitamins Glycoside Hydrolases - antagonists & inhibitors Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Spectrum Analysis
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