Regulation of FRTL-5 Thyroid Cell Growth by Phosphatidylinositol (OH) 3 Kinase-Dependent Akt-Mediated Signaling

Thyrotropin (TSH)-initiated cell cycle progression from G 1 to S phase in FRTL-5 thyroid cells requires serum, insulin, or insulin-like growth factor 1 (IGF-1) and involves activation of 3-hydroxy-3-methylglutaryl-CoA reductase, geranylgeranylation of RhoA, p27 Kip1 degradation, and activation of cy...

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Veröffentlicht in:	Thyroid (New York, N.Y.) N.Y.), 2001-04, Vol.11 (4), p.339-351
Hauptverfasser:	Saito, Jun, Kohn, Aimee D., Roth, Richard A., Noguchi, Yoshihiko, Tatsumo, Ichiro, Hirai, Aizan, Suzuki, Koichi, Kohn, Leonard D., Saji, Motoyasu, Ringel, Matthew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Cell Division Cell Line DNA - biosynthesis Hydroxymethylglutaryl CoA Reductases - genetics Insulin - pharmacology Insulin-Like Growth Factor I - pharmacology Laboratory Research Reports Phosphatidylinositol 3-Kinases - physiology Phosphorylation Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-akt Rats Thyroid Gland - cytology Thyrotropin - pharmacology
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