Differences in genetic predisposition to high anxiety in two inbred rat strains : role of substance P, diazepam binding inhibitor fragment and neuropeptide Y

Regulatory neuropeptide systems appear to modulate anxiety and emotionality, since anxiety in rats can be increased by intracerebroventricular (ICV) administration of diazepam-binding-inhibitor fragment (DBI) and decreased by ICV administration of neuropeptide Y (NPY) or substance P (SP). Involvemen...

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Veröffentlicht in:	Psychopharmacologia 2001-04, Vol.154 (4), p.327-335
Hauptverfasser:	SUDAKOV, S. K, MEDVEDEVA, O. F, RUSAKOVA, I. V, TEREBILINA, N. N, GOLDBERG, S. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety Anxiety - genetics Anxiety - metabolism Behavior, Animal - drug effects Behavior, Animal - physiology Diazepam diazepam-binding-inhibitor fragment Genetic Predisposition to Disease - genetics Hippocampus Hippocampus - metabolism Hypothalamus Hypothalamus - metabolism Inbreeding Intracerebroventricular administration Male Mesencephalon Mesencephalon - metabolism Neuropeptide Y Neuropeptide Y - genetics Neuropeptide Y - metabolism Neuropeptide Y - pharmacology Neuropeptides Rats Rats, Inbred F344 Rats, Wistar Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Species Specificity Stress, Physiological - genetics Stress, Physiological - metabolism Substance P Substance P - genetics Substance P - metabolism Substance P - physiology
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