Prolonged postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex in patients with cerebellar ataxia
Postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex (silent period, SP) is supposed to be predominantly mediated by the activation of inhibitory cortical interneurons. Cortical excitability seems to be reduced in patients with cerebellar ataxia. Motor threshold, cen...
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| Veröffentlicht in: | Journal of the neurological sciences 1999-10, Vol.168 (2), p.107-111 |
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| container_title | Journal of the neurological sciences |
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| creator | Oechsner, Matthias Zangemeister, Wolfgang H |
| description | Postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex (silent period, SP) is supposed to be predominantly mediated by the activation of inhibitory cortical interneurons. Cortical excitability seems to be reduced in patients with cerebellar ataxia. Motor threshold, central motor conduction time and the duration of the silent period after a single magnetic stimulus to the motor cortex on both sides were measured in five patients with cerebellar ataxia of different origin and 18 healthy controls. Duration of SP was highly significantly prolonged in patients compared with controls (
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| doi_str_mv | 10.1016/S0022-510X(99)00164-1 |
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P<0.001) while motor threshold and central motor conduction times were not different. Fifteen of 18 control subjects showed late EMG responses after magnetic stimulation but none of the patients did (
P<0.001). These findings support the hypothesis that cerebellar lesions activate inhibitory cortical interneurons or cause a disruption of a normally tonic cerebellar excitation to the motor cortex. Silent period measurement appears to be a sensitive diagnostic tool in the neurophysiological examination of cerebellar diseases.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/S0022-510X(99)00164-1</identifier><identifier>PMID: 10526191</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Ataxia ; Biological and medical sciences ; Cerebellar Ataxia - physiopathology ; Cerebellum ; Cortical silent period ; Electric Stimulation ; Electromyography ; Evoked Potentials, Motor - physiology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Motor Cortex - physiopathology ; Motor cortex excitability ; Muscle Contraction - physiology ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neural Inhibition - physiology ; Neurology ; Reaction Time - physiology ; Sensory Thresholds - physiology ; Time Factors ; Transcranial Magnetic Stimulation</subject><ispartof>Journal of the neurological sciences, 1999-10, Vol.168 (2), p.107-111</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-257fa974f7311d824b4786f14a0e313258e9fc149e089159df8dfe029cd3d1b63</citedby><cites>FETCH-LOGICAL-c390t-257fa974f7311d824b4786f14a0e313258e9fc149e089159df8dfe029cd3d1b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022510X99001641$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1998047$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10526191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oechsner, Matthias</creatorcontrib><creatorcontrib>Zangemeister, Wolfgang H</creatorcontrib><title>Prolonged postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex in patients with cerebellar ataxia</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex (silent period, SP) is supposed to be predominantly mediated by the activation of inhibitory cortical interneurons. Cortical excitability seems to be reduced in patients with cerebellar ataxia. Motor threshold, central motor conduction time and the duration of the silent period after a single magnetic stimulus to the motor cortex on both sides were measured in five patients with cerebellar ataxia of different origin and 18 healthy controls. Duration of SP was highly significantly prolonged in patients compared with controls (
P<0.001) while motor threshold and central motor conduction times were not different. Fifteen of 18 control subjects showed late EMG responses after magnetic stimulation but none of the patients did (
P<0.001). These findings support the hypothesis that cerebellar lesions activate inhibitory cortical interneurons or cause a disruption of a normally tonic cerebellar excitation to the motor cortex. Silent period measurement appears to be a sensitive diagnostic tool in the neurophysiological examination of cerebellar diseases.</description><subject>Adult</subject><subject>Ataxia</subject><subject>Biological and medical sciences</subject><subject>Cerebellar Ataxia - physiopathology</subject><subject>Cerebellum</subject><subject>Cortical silent period</subject><subject>Electric Stimulation</subject><subject>Electromyography</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Cortex - physiopathology</subject><subject>Motor cortex excitability</subject><subject>Muscle Contraction - physiology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neural Inhibition - physiology</subject><subject>Neurology</subject><subject>Reaction Time - physiology</subject><subject>Sensory Thresholds - physiology</subject><subject>Time Factors</subject><subject>Transcranial Magnetic Stimulation</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEuLFTEQRoM4ONfRn6BkIaKL1qp-JiuRwcfAgIIK7kI6qcyNdHeuSa7ObP3l5j4YZ-cmBalTXxWHsScIrxCwf_0FoK6rDuH7CylfQvlqK7zHVigGUXVCNPfZ6hY5ZQ9T-gEAvRDyATtF6OoeJa7Yn88xTGG5Iss3IWW6Nj7rHOIN98vajz77sHDtMkWeo16SKY_XE5_11ULZG56yn7eT3nPB8bwmPocSwE2IJa7E8E3p0pIT_-3zmhuKNNI06ch11tdeP2InTk-JHh_rGfv2_t3X84_V5acPF-dvLyvTSMhV3Q1Oy6F1Q4NoRd2O7SB6h60GarCpO0HSGWwlgZDYSeuEdQS1NLaxOPbNGXt-yN3E8HNLKavZJ7O7ZKGwTWoA0fZDhwXsDqCJIaVITm2in3W8UQhqJ1_t5audWSWl2stXu7mnxwXbcSZ7Z-pguwDPjoBORk-uuDQ-_eOkFNAOBXtzwKjY-OUpqmSKQEPWRzJZ2eD_c8lf8bWkSw</recordid><startdate>19991015</startdate><enddate>19991015</enddate><creator>Oechsner, Matthias</creator><creator>Zangemeister, Wolfgang H</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991015</creationdate><title>Prolonged postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex in patients with cerebellar ataxia</title><author>Oechsner, Matthias ; Zangemeister, Wolfgang H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-257fa974f7311d824b4786f14a0e313258e9fc149e089159df8dfe029cd3d1b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Ataxia</topic><topic>Biological and medical sciences</topic><topic>Cerebellar Ataxia - physiopathology</topic><topic>Cerebellum</topic><topic>Cortical silent period</topic><topic>Electric Stimulation</topic><topic>Electromyography</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Cortex - physiopathology</topic><topic>Motor cortex excitability</topic><topic>Muscle Contraction - physiology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neural Inhibition - physiology</topic><topic>Neurology</topic><topic>Reaction Time - physiology</topic><topic>Sensory Thresholds - physiology</topic><topic>Time Factors</topic><topic>Transcranial Magnetic Stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oechsner, Matthias</creatorcontrib><creatorcontrib>Zangemeister, Wolfgang H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oechsner, Matthias</au><au>Zangemeister, Wolfgang H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex in patients with cerebellar ataxia</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1999-10-15</date><risdate>1999</risdate><volume>168</volume><issue>2</issue><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex (silent period, SP) is supposed to be predominantly mediated by the activation of inhibitory cortical interneurons. Cortical excitability seems to be reduced in patients with cerebellar ataxia. Motor threshold, central motor conduction time and the duration of the silent period after a single magnetic stimulus to the motor cortex on both sides were measured in five patients with cerebellar ataxia of different origin and 18 healthy controls. Duration of SP was highly significantly prolonged in patients compared with controls (
P<0.001) while motor threshold and central motor conduction times were not different. Fifteen of 18 control subjects showed late EMG responses after magnetic stimulation but none of the patients did (
P<0.001). These findings support the hypothesis that cerebellar lesions activate inhibitory cortical interneurons or cause a disruption of a normally tonic cerebellar excitation to the motor cortex. Silent period measurement appears to be a sensitive diagnostic tool in the neurophysiological examination of cerebellar diseases.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>10526191</pmid><doi>10.1016/S0022-510X(99)00164-1</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Ataxia Biological and medical sciences Cerebellar Ataxia - physiopathology Cerebellum Cortical silent period Electric Stimulation Electromyography Evoked Potentials, Motor - physiology Female Humans Male Medical sciences Middle Aged Motor Cortex - physiopathology Motor cortex excitability Muscle Contraction - physiology Nervous system (semeiology, syndromes) Nervous system as a whole Neural Inhibition - physiology Neurology Reaction Time - physiology Sensory Thresholds - physiology Time Factors Transcranial Magnetic Stimulation |
| title | Prolonged postexcitatory inhibition after transcranial magnetic stimulation of the motor cortex in patients with cerebellar ataxia |
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