Diagnosis of burn depth using laser-induced indocyanine green fluorescence: a preliminary clinical trial
Clinical assessment of burn depth is frequently inaccurate. In order to effectively plan the treatment of burn wounds, an accurate diagnosis of burn depth is desirable. A new method for evaluating the depth of burns by imaging the blood flow through the burned tissue using fluorescence from intraven...
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| Veröffentlicht in: | Burns 2001-06, Vol.27 (4), p.364-371 |
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| container_issue | 4 |
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| container_title | Burns |
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| creator | Still, J.M Law, E.J Klavuhn, K.G Island, T.C Holtz, J.Z |
| description | Clinical assessment of burn depth is frequently inaccurate. In order to effectively plan the treatment of burn wounds, an accurate diagnosis of burn depth is desirable. A new method for evaluating the depth of burns by imaging the blood flow through the burned tissue using fluorescence from intravenously injected indocyanine green (ICG) dye illuminated with a 785-nm, near-infrared diode laser array was evaluated. Nine patients and 15 individual burn sites were studied. Five sites were classified by the ICG study as superficial second degree, four were deep-dermal second degree, and six were third degree. Etiology of the injuries included flame, contact burns, and scalds. The date postburn of the study ranged from 1 to 11 days. In all cases, the relative fluorescence levels (e.g. superficial second-degree burns yielded relatively bright fluorescence, third-degree burns appeared much darker than surrounding normal skin) were found to correlate well with actual burn depth as determined by histologic examination of biopsies and intraoperative clinical assessment. |
| doi_str_mv | 10.1016/S0305-4179(00)00140-6 |
| format | Article |
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In order to effectively plan the treatment of burn wounds, an accurate diagnosis of burn depth is desirable. A new method for evaluating the depth of burns by imaging the blood flow through the burned tissue using fluorescence from intravenously injected indocyanine green (ICG) dye illuminated with a 785-nm, near-infrared diode laser array was evaluated. Nine patients and 15 individual burn sites were studied. Five sites were classified by the ICG study as superficial second degree, four were deep-dermal second degree, and six were third degree. Etiology of the injuries included flame, contact burns, and scalds. The date postburn of the study ranged from 1 to 11 days. In all cases, the relative fluorescence levels (e.g. superficial second-degree burns yielded relatively bright fluorescence, third-degree burns appeared much darker than surrounding normal skin) were found to correlate well with actual burn depth as determined by histologic examination of biopsies and intraoperative clinical assessment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Burn depth</subject><subject>Burns</subject><subject>Burns - pathology</subject><subject>Burns - physiopathology</subject><subject>Coloring Agents</subject><subject>Dermatology</subject><subject>Fluorescence</subject><subject>Fluorescence imaging</subject><subject>Humans</subject><subject>Indocyanine Green</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lasers</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. 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Miscellaneous investigative techniques</topic><topic>Skin - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Still, J.M</creatorcontrib><creatorcontrib>Law, E.J</creatorcontrib><creatorcontrib>Klavuhn, K.G</creatorcontrib><creatorcontrib>Island, T.C</creatorcontrib><creatorcontrib>Holtz, J.Z</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Still, J.M</au><au>Law, E.J</au><au>Klavuhn, K.G</au><au>Island, T.C</au><au>Holtz, J.Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of burn depth using laser-induced indocyanine green fluorescence: a preliminary clinical trial</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>27</volume><issue>4</issue><spage>364</spage><epage>371</epage><pages>364-371</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><coden>BURND8</coden><abstract>Clinical assessment of burn depth is frequently inaccurate. In order to effectively plan the treatment of burn wounds, an accurate diagnosis of burn depth is desirable. A new method for evaluating the depth of burns by imaging the blood flow through the burned tissue using fluorescence from intravenously injected indocyanine green (ICG) dye illuminated with a 785-nm, near-infrared diode laser array was evaluated. Nine patients and 15 individual burn sites were studied. Five sites were classified by the ICG study as superficial second degree, four were deep-dermal second degree, and six were third degree. Etiology of the injuries included flame, contact burns, and scalds. The date postburn of the study ranged from 1 to 11 days. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Biological and medical sciences Burn depth Burns Burns - pathology Burns - physiopathology Coloring Agents Dermatology Fluorescence Fluorescence imaging Humans Indocyanine Green Investigative techniques, diagnostic techniques (general aspects) Lasers Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Skin - blood supply |
| title | Diagnosis of burn depth using laser-induced indocyanine green fluorescence: a preliminary clinical trial |
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