Effects of sulfonylurea derivatives on ischemia-induced loss of function in the isolated rat heart

This study determined whether sulfonylurea derivatives affect cardiac function prior to and after a mild ischemic incident (stunning). This was investigated using an isolated, erythrocyte-perfused, working rat heart model. In total, 11 groups were studied: five increasing (clinically relevant) conce...

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Veröffentlicht in:	European journal of pharmacology 2001-05, Vol.419 (1), p.85-92
Hauptverfasser:	Legtenberg, Roger J, Houston, Ralph J.F, Oeseburg, Berend, Smits, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - pharmacology Biological and medical sciences Cardiovascular Coronary Circulation - drug effects Coronary Circulation - physiology Diabetes type 2 Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Glyburide - pharmacology Heart Heart - drug effects Heart - physiopathology In Vitro Techniques K ATP channel Male Medical sciences Myocardial Stunning - physiopathology Pharmacology. Drug treatments Rats Rats, Wistar Sulfonylurea Compounds - pharmacology Toxicity: cardiovascular system Ventricular
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