Metamorphosis in the Summer Flounder, Paralichthys dentatus: Thyroidal Status Influences Gill Mitochondria-Rich Cells
Metamorphosis in the summer flounder (Paralichthys dentatus) is mediated by thyroid hormones (TH) and is accompanied by changes in gill mitochondria-rich cells (MRCs) and in salinity tolerance. Altered thyroid status during larval development and metamorphosis in this species influences salinity tol...
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| Veröffentlicht in: | General and comparative endocrinology 2000-02, Vol.117 (2), p.238-250 |
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| description | Metamorphosis in the summer flounder (Paralichthys dentatus) is mediated by thyroid hormones (TH) and is accompanied by changes in gill mitochondria-rich cells (MRCs) and in salinity tolerance. Altered thyroid status during larval development and metamorphosis in this species influences salinity tolerance, though the influence of any hormone on MRCs of larval marine teleosts is not known. This study characterized the effect of altered thyroid status on MRC intracellular membranes, mitochondria size and ultrastructure, immunoreactive (ir)-Na+,K+-ATPase, and cell size and density during metamorphosis in summer flounder. Inhibition of metamorphosis with thiourea (30 ppm) (TU, an inhibitor of TH synthesis) inhibited changes in MRCs, producing large “larval” type MRCs with weak reactivity to osmium; large, electron-lucent mitochondria; and weak ir-Na+,K+-ATPase. Replacement of TH with TU + thyroxine–Na salt (100 ppb) rescued the fish from developmental inhibition, producing smaller “juvenile” type MRCs with strong reactivity to osmium; smaller, electron-opaque mitochondria; and strong ir-Na+,K+-ATPase. The findings suggest that TH are necessary for MRCs to change from larval to juvenile form during metamorphosis. |
| doi_str_mv | 10.1006/gcen.1999.7407 |
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Altered thyroid status during larval development and metamorphosis in this species influences salinity tolerance, though the influence of any hormone on MRCs of larval marine teleosts is not known. This study characterized the effect of altered thyroid status on MRC intracellular membranes, mitochondria size and ultrastructure, immunoreactive (ir)-Na+,K+-ATPase, and cell size and density during metamorphosis in summer flounder. Inhibition of metamorphosis with thiourea (30 ppm) (TU, an inhibitor of TH synthesis) inhibited changes in MRCs, producing large “larval” type MRCs with weak reactivity to osmium; large, electron-lucent mitochondria; and weak ir-Na+,K+-ATPase. Replacement of TH with TU + thyroxine–Na salt (100 ppb) rescued the fish from developmental inhibition, producing smaller “juvenile” type MRCs with strong reactivity to osmium; smaller, electron-opaque mitochondria; and strong ir-Na+,K+-ATPase. The findings suggest that TH are necessary for MRCs to change from larval to juvenile form during metamorphosis.</description><identifier>ISSN: 0016-6480</identifier><identifier>EISSN: 1095-6840</identifier><identifier>DOI: 10.1006/gcen.1999.7407</identifier><identifier>PMID: 10642446</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antithyroid Agents - pharmacology ; Brackish ; chloride cell ; flounder ; Flounder - physiology ; Freshwater ; Gills - cytology ; Gills - growth & development ; Gills - ultrastructure ; Image Processing, Computer-Assisted ; Immunohistochemistry ; Larva - physiology ; Marine ; metamorphosis ; Metamorphosis, Biological - physiology ; Microscopy, Electron ; Mitochondria - enzymology ; Mitochondria - physiology ; mitochondria-rich cell ; Osmium ; osmoregulation ; Paralichthys dentatus ; Sodium-Potassium-Exchanging ATPase - metabolism ; Thiourea - pharmacology ; Thyroid Gland - drug effects ; Thyroid Gland - physiology ; thyroid hormone ; Thyroxine - blood ; Water-Electrolyte Balance - physiology</subject><ispartof>General and comparative endocrinology, 2000-02, Vol.117 (2), p.238-250</ispartof><rights>2000 Academic Press</rights><rights>Copyright 2000 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-6256f233ecc8da0e964ef3d08a4f7984324102dfa3ef3bd37b98013eb8206d393</citedby><cites>FETCH-LOGICAL-c437t-6256f233ecc8da0e964ef3d08a4f7984324102dfa3ef3bd37b98013eb8206d393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/gcen.1999.7407$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10642446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schreiber, Alex M.</creatorcontrib><creatorcontrib>Specker, Jennifer L.</creatorcontrib><title>Metamorphosis in the Summer Flounder, Paralichthys dentatus: Thyroidal Status Influences Gill Mitochondria-Rich Cells</title><title>General and comparative endocrinology</title><addtitle>Gen Comp Endocrinol</addtitle><description>Metamorphosis in the summer flounder (Paralichthys dentatus) is mediated by thyroid hormones (TH) and is accompanied by changes in gill mitochondria-rich cells (MRCs) and in salinity tolerance. Altered thyroid status during larval development and metamorphosis in this species influences salinity tolerance, though the influence of any hormone on MRCs of larval marine teleosts is not known. This study characterized the effect of altered thyroid status on MRC intracellular membranes, mitochondria size and ultrastructure, immunoreactive (ir)-Na+,K+-ATPase, and cell size and density during metamorphosis in summer flounder. Inhibition of metamorphosis with thiourea (30 ppm) (TU, an inhibitor of TH synthesis) inhibited changes in MRCs, producing large “larval” type MRCs with weak reactivity to osmium; large, electron-lucent mitochondria; and weak ir-Na+,K+-ATPase. Replacement of TH with TU + thyroxine–Na salt (100 ppb) rescued the fish from developmental inhibition, producing smaller “juvenile” type MRCs with strong reactivity to osmium; smaller, electron-opaque mitochondria; and strong ir-Na+,K+-ATPase. The findings suggest that TH are necessary for MRCs to change from larval to juvenile form during metamorphosis.</description><subject>Animals</subject><subject>Antithyroid Agents - pharmacology</subject><subject>Brackish</subject><subject>chloride cell</subject><subject>flounder</subject><subject>Flounder - physiology</subject><subject>Freshwater</subject><subject>Gills - cytology</subject><subject>Gills - growth & development</subject><subject>Gills - ultrastructure</subject><subject>Image Processing, Computer-Assisted</subject><subject>Immunohistochemistry</subject><subject>Larva - physiology</subject><subject>Marine</subject><subject>metamorphosis</subject><subject>Metamorphosis, Biological - physiology</subject><subject>Microscopy, Electron</subject><subject>Mitochondria - enzymology</subject><subject>Mitochondria - physiology</subject><subject>mitochondria-rich cell</subject><subject>Osmium</subject><subject>osmoregulation</subject><subject>Paralichthys dentatus</subject><subject>Sodium-Potassium-Exchanging ATPase - metabolism</subject><subject>Thiourea - pharmacology</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - physiology</subject><subject>thyroid hormone</subject><subject>Thyroxine - blood</subject><subject>Water-Electrolyte Balance - physiology</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQRi0EokvhyhH5xIks49jrONzQqi2VWrWi5Wx57QkxcuLFdirtvydhe-il6mmkT28-jeYR8pHBmgHIr78tjmvWtu26EdC8IisG7aaSSsBrsgJgspJCwQl5l_MfANhwyd6SEwZS1ELIFZmusZghpn0fs8_Uj7T0SO-mYcBEz0OcRofpC701yQRv-9IfMnU4FlOm_I3e94cUvTOB3v1P6OXYhQlHi5le-BDotS_R9nF0yZvq51xAtxhCfk_edCZk_PA4T8mv87P77Y_q6ubicvv9qrKCN6WS9UZ2NedorXIGsJUCO-5AGdE1rRK8Fgxq1xk-xzvHm12rgHHcqRqk4y0_JZ-PvfsU_06Yix58tvMFZsQ4Zd2AEqJtmhdBptjMynoG10fQpphzwk7vkx9MOmgGejGiFyN6MaIXI_PCp8fmaTege4IfFcyAOgI4P-LBY9LZ-uWFzie0Rbvon-v-B-Emm8E</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Schreiber, Alex M.</creator><creator>Specker, Jennifer L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Metamorphosis in the Summer Flounder, Paralichthys dentatus: Thyroidal Status Influences Gill Mitochondria-Rich Cells</title><author>Schreiber, Alex M. ; Specker, Jennifer L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-6256f233ecc8da0e964ef3d08a4f7984324102dfa3ef3bd37b98013eb8206d393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antithyroid Agents - pharmacology</topic><topic>Brackish</topic><topic>chloride cell</topic><topic>flounder</topic><topic>Flounder - physiology</topic><topic>Freshwater</topic><topic>Gills - cytology</topic><topic>Gills - growth & development</topic><topic>Gills - ultrastructure</topic><topic>Image Processing, Computer-Assisted</topic><topic>Immunohistochemistry</topic><topic>Larva - physiology</topic><topic>Marine</topic><topic>metamorphosis</topic><topic>Metamorphosis, Biological - physiology</topic><topic>Microscopy, Electron</topic><topic>Mitochondria - enzymology</topic><topic>Mitochondria - physiology</topic><topic>mitochondria-rich cell</topic><topic>Osmium</topic><topic>osmoregulation</topic><topic>Paralichthys dentatus</topic><topic>Sodium-Potassium-Exchanging ATPase - metabolism</topic><topic>Thiourea - pharmacology</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - physiology</topic><topic>thyroid hormone</topic><topic>Thyroxine - blood</topic><topic>Water-Electrolyte Balance - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schreiber, Alex M.</creatorcontrib><creatorcontrib>Specker, Jennifer L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schreiber, Alex M.</au><au>Specker, Jennifer L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metamorphosis in the Summer Flounder, Paralichthys dentatus: Thyroidal Status Influences Gill Mitochondria-Rich Cells</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>117</volume><issue>2</issue><spage>238</spage><epage>250</epage><pages>238-250</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>Metamorphosis in the summer flounder (Paralichthys dentatus) is mediated by thyroid hormones (TH) and is accompanied by changes in gill mitochondria-rich cells (MRCs) and in salinity tolerance. Altered thyroid status during larval development and metamorphosis in this species influences salinity tolerance, though the influence of any hormone on MRCs of larval marine teleosts is not known. This study characterized the effect of altered thyroid status on MRC intracellular membranes, mitochondria size and ultrastructure, immunoreactive (ir)-Na+,K+-ATPase, and cell size and density during metamorphosis in summer flounder. Inhibition of metamorphosis with thiourea (30 ppm) (TU, an inhibitor of TH synthesis) inhibited changes in MRCs, producing large “larval” type MRCs with weak reactivity to osmium; large, electron-lucent mitochondria; and weak ir-Na+,K+-ATPase. Replacement of TH with TU + thyroxine–Na salt (100 ppb) rescued the fish from developmental inhibition, producing smaller “juvenile” type MRCs with strong reactivity to osmium; smaller, electron-opaque mitochondria; and strong ir-Na+,K+-ATPase. The findings suggest that TH are necessary for MRCs to change from larval to juvenile form during metamorphosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10642446</pmid><doi>10.1006/gcen.1999.7407</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Antithyroid Agents - pharmacology Brackish chloride cell flounder Flounder - physiology Freshwater Gills - cytology Gills - growth & development Gills - ultrastructure Image Processing, Computer-Assisted Immunohistochemistry Larva - physiology Marine metamorphosis Metamorphosis, Biological - physiology Microscopy, Electron Mitochondria - enzymology Mitochondria - physiology mitochondria-rich cell Osmium osmoregulation Paralichthys dentatus Sodium-Potassium-Exchanging ATPase - metabolism Thiourea - pharmacology Thyroid Gland - drug effects Thyroid Gland - physiology thyroid hormone Thyroxine - blood Water-Electrolyte Balance - physiology |
| title | Metamorphosis in the Summer Flounder, Paralichthys dentatus: Thyroidal Status Influences Gill Mitochondria-Rich Cells |
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