Hepatocellular carcinoma associated with focal nodular hyperplasia : Report of a case with clonal analysis
We describe a hepatocellular carcinoma partially surrounded by focal nodular hyperplasia in a 65-year-old female patient. In order to clarify the relationship of the hepatocellular carcinoma and the adjacent focal nodular hyperplasia, clonal analysis was conducted. The clonal analysis was based on t...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2001-04, Vol.438 (4), p.408-411 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | CHEN, Tse-Ching CHOU, Tze-Bin NG, Kwai-Fong HSIEH, Ling-Ling CHOU, Yah-Huei Wu |
| description | We describe a hepatocellular carcinoma partially surrounded by focal nodular hyperplasia in a 65-year-old female patient. In order to clarify the relationship of the hepatocellular carcinoma and the adjacent focal nodular hyperplasia, clonal analysis was conducted. The clonal analysis was based on the methylation pattern of the polymorphic X-chromosome-linked androgen receptor gene (HUMARA). The allelic bands from the amplification of the focal nodular hyperplasia and of the hepatocellular carcinoma showed a significant reduction in the intensity of one of the two alleles as compared with two alleles of equal intensity in the buff coat after HhaI digestion, which indicated that these two parts were monoclonal. However, the inactivated allele in the focal nodular hyperplasia and that in the hepatocellular carcinoma were not identical. Therefore, the focal nodular hyperplasia and hepatocellular carcinoma probably derived from the clonal expansion of two different clones. |
| doi_str_mv | 10.1007/s004280000348 |
| format | Article |
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In order to clarify the relationship of the hepatocellular carcinoma and the adjacent focal nodular hyperplasia, clonal analysis was conducted. The clonal analysis was based on the methylation pattern of the polymorphic X-chromosome-linked androgen receptor gene (HUMARA). The allelic bands from the amplification of the focal nodular hyperplasia and of the hepatocellular carcinoma showed a significant reduction in the intensity of one of the two alleles as compared with two alleles of equal intensity in the buff coat after HhaI digestion, which indicated that these two parts were monoclonal. However, the inactivated allele in the focal nodular hyperplasia and that in the hepatocellular carcinoma were not identical. Therefore, the focal nodular hyperplasia and hepatocellular carcinoma probably derived from the clonal expansion of two different clones.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s004280000348</identifier><identifier>PMID: 11355178</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Clone Cells - metabolism ; DNA Primers - chemistry ; DNA, Neoplasm - analysis ; Female ; Focal Nodular Hyperplasia - complications ; Focal Nodular Hyperplasia - genetics ; Focal Nodular Hyperplasia - metabolism ; Focal Nodular Hyperplasia - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver Neoplasms - complications ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Polymerase Chain Reaction ; Receptors, Androgen - metabolism ; Tropical medicine ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2001-04, Vol.438 (4), p.408-411</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=964621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11355178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEN, Tse-Ching</creatorcontrib><creatorcontrib>CHOU, Tze-Bin</creatorcontrib><creatorcontrib>NG, Kwai-Fong</creatorcontrib><creatorcontrib>HSIEH, Ling-Ling</creatorcontrib><creatorcontrib>CHOU, Yah-Huei Wu</creatorcontrib><title>Hepatocellular carcinoma associated with focal nodular hyperplasia : Report of a case with clonal analysis</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><description>We describe a hepatocellular carcinoma partially surrounded by focal nodular hyperplasia in a 65-year-old female patient. In order to clarify the relationship of the hepatocellular carcinoma and the adjacent focal nodular hyperplasia, clonal analysis was conducted. The clonal analysis was based on the methylation pattern of the polymorphic X-chromosome-linked androgen receptor gene (HUMARA). The allelic bands from the amplification of the focal nodular hyperplasia and of the hepatocellular carcinoma showed a significant reduction in the intensity of one of the two alleles as compared with two alleles of equal intensity in the buff coat after HhaI digestion, which indicated that these two parts were monoclonal. However, the inactivated allele in the focal nodular hyperplasia and that in the hepatocellular carcinoma were not identical. Therefore, the focal nodular hyperplasia and hepatocellular carcinoma probably derived from the clonal expansion of two different clones.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - complications</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Clone Cells - metabolism</subject><subject>DNA Primers - chemistry</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Focal Nodular Hyperplasia - complications</subject><subject>Focal Nodular Hyperplasia - genetics</subject><subject>Focal Nodular Hyperplasia - metabolism</subject><subject>Focal Nodular Hyperplasia - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Polymerase Chain Reaction</subject><subject>Receptors, Androgen - metabolism</subject><subject>Tropical medicine</subject><subject>Tumors</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRbK0evcqC4C26X8luvElRKxQE0XOYbHZpSpqNOwnSf29qi-IcZi7P-8I8hFxydssZ03fImBKGjSOVOSJTrqRIhGT6mExZrtIkk1xPyBnimjHBDc9OyYRzmaZcmylZL1wHfbCuaYYGIrUQbd2GDVBADLaG3lX0q-5X1AcLDW1D9cOttp2LXQNYA72nb64LsafBUxgb0O0TtgntGIFxbbHGc3LioUF3cbgz8vH0-D5fJMvX55f5wzKxQss-KdPMltqb3KSl5pUR2nqf61zkmSw5KMGZMOCdSJ1LFbiqVFpJbRWzOs2rXM7Izb63i-FzcNgXmxp3D0LrwoCFZkYpzuQIJnvQxoAYnS-6WG8gbgvOip3c4p_ckb86FA_lxlV_9MHmCFwfAMBRlo_Q2hp_uTxTmeDyG2yUgaQ</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>CHEN, Tse-Ching</creator><creator>CHOU, Tze-Bin</creator><creator>NG, Kwai-Fong</creator><creator>HSIEH, Ling-Ling</creator><creator>CHOU, Yah-Huei Wu</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Hepatocellular carcinoma associated with focal nodular hyperplasia : Report of a case with clonal analysis</title><author>CHEN, Tse-Ching ; CHOU, Tze-Bin ; NG, Kwai-Fong ; HSIEH, Ling-Ling ; CHOU, Yah-Huei Wu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-b56cb7f8985b71d827cff9792963b1a421028afe25ee54aedb47437c40c759d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - complications</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Clone Cells - metabolism</topic><topic>DNA Primers - chemistry</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Focal Nodular Hyperplasia - complications</topic><topic>Focal Nodular Hyperplasia - genetics</topic><topic>Focal Nodular Hyperplasia - metabolism</topic><topic>Focal Nodular Hyperplasia - pathology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Polymerase Chain Reaction</topic><topic>Receptors, Androgen - metabolism</topic><topic>Tropical medicine</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEN, Tse-Ching</creatorcontrib><creatorcontrib>CHOU, Tze-Bin</creatorcontrib><creatorcontrib>NG, Kwai-Fong</creatorcontrib><creatorcontrib>HSIEH, Ling-Ling</creatorcontrib><creatorcontrib>CHOU, Yah-Huei Wu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEN, Tse-Ching</au><au>CHOU, Tze-Bin</au><au>NG, Kwai-Fong</au><au>HSIEH, Ling-Ling</au><au>CHOU, Yah-Huei Wu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocellular carcinoma associated with focal nodular hyperplasia : Report of a case with clonal analysis</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><addtitle>Virchows Arch</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>438</volume><issue>4</issue><spage>408</spage><epage>411</epage><pages>408-411</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>We describe a hepatocellular carcinoma partially surrounded by focal nodular hyperplasia in a 65-year-old female patient. In order to clarify the relationship of the hepatocellular carcinoma and the adjacent focal nodular hyperplasia, clonal analysis was conducted. The clonal analysis was based on the methylation pattern of the polymorphic X-chromosome-linked androgen receptor gene (HUMARA). The allelic bands from the amplification of the focal nodular hyperplasia and of the hepatocellular carcinoma showed a significant reduction in the intensity of one of the two alleles as compared with two alleles of equal intensity in the buff coat after HhaI digestion, which indicated that these two parts were monoclonal. However, the inactivated allele in the focal nodular hyperplasia and that in the hepatocellular carcinoma were not identical. Therefore, the focal nodular hyperplasia and hepatocellular carcinoma probably derived from the clonal expansion of two different clones.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11355178</pmid><doi>10.1007/s004280000348</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Clone Cells - metabolism DNA Primers - chemistry DNA, Neoplasm - analysis Female Focal Nodular Hyperplasia - complications Focal Nodular Hyperplasia - genetics Focal Nodular Hyperplasia - metabolism Focal Nodular Hyperplasia - pathology Gastroenterology. Liver. Pancreas. Abdomen Humans Liver Neoplasms - complications Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Polymerase Chain Reaction Receptors, Androgen - metabolism Tropical medicine Tumors |
| title | Hepatocellular carcinoma associated with focal nodular hyperplasia : Report of a case with clonal analysis |
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