Transpupillary thermotherapy of occult subfoveal choroidal neovascularization in patients with age-related macular degeneration
To evaluate the efficacy of transpupillary thermotherapy for the treatment of occult subfoveal choroidal neovascularization (CNV) in patients with age-related macular degeneration. A retrospective, noncomparative case series. Sixteen eyes of 15 consecutive patients who presented with occult subfovea...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 1999-10, Vol.106 (10), p.1908-1914 |
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| container_title | Ophthalmology (Rochester, Minn.) |
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| creator | Reichel, Elias Berrocal, Audina M Ip, Michael Kroll, Arnold J Desai, Vinay Duker, Jay S Puliafito, Carmen A |
| description | To evaluate the efficacy of transpupillary thermotherapy for the treatment of occult subfoveal choroidal neovascularization (CNV) in patients with age-related macular degeneration.
A retrospective, noncomparative case series.
Sixteen eyes of 15 consecutive patients who presented with occult subfoveal choroidal neovascularization secondary to age-related macular degeneration.
After informed consent was obtained, 16 eyes of 15 patients were treated with transpupillary thermotherapy. All patients underwent pretreatment fluorescein angiography and were deemed untreatable by the Macular Photocoagulation Study standard. Transpupillary thermotherapy was delivered using a diode laser at 810 nm. A variable spot size of 1.2 mm, 2.0 mm, or 3.0 mm was used depending on the size of CNV. The diode laser was delivered through a contact lens, and treatment was initiated in one spot for 60 seconds’ duration at a power range between 360 and 1000 mW. The end point was an area of no visible color change to a light-gray appearance.
In all eyes, outcome was assessed by Snellen chart visual acuity and clinical examination. In 10 of 16 eyes, preoperative and postoperative fluorescein angiography and optical coherence tomography were available. In the remaining 6 of 16 eyes, exudation was measured by postoperative clinical examination alone.
Three eyes (19%) showed a two-or-more-line improvement in visual acuity over a period of 6 to 25 months. Mean follow-up was 13 months. Visual acuity remained stable (no change or one-line improvement) in nine treated eyes (56%). The remaining four eyes (25%) showed a decline (equal to one-line worsening or greater) in visual acuity. Fifteen eyes (94%) demonstrated decreased exudation on fluorescein angiography, optical coherence tomography, and/or clinical examination.
Transpupillary thermotherapy shows no deleterious side effects in treating occult subfoveal choroidal neovascularization. A randomized, prospective study is necessary to evaluate treatment efficacy. |
| doi_str_mv | 10.1016/S0161-6420(99)90400-1 |
| format | Article |
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A retrospective, noncomparative case series.
Sixteen eyes of 15 consecutive patients who presented with occult subfoveal choroidal neovascularization secondary to age-related macular degeneration.
After informed consent was obtained, 16 eyes of 15 patients were treated with transpupillary thermotherapy. All patients underwent pretreatment fluorescein angiography and were deemed untreatable by the Macular Photocoagulation Study standard. Transpupillary thermotherapy was delivered using a diode laser at 810 nm. A variable spot size of 1.2 mm, 2.0 mm, or 3.0 mm was used depending on the size of CNV. The diode laser was delivered through a contact lens, and treatment was initiated in one spot for 60 seconds’ duration at a power range between 360 and 1000 mW. The end point was an area of no visible color change to a light-gray appearance.
In all eyes, outcome was assessed by Snellen chart visual acuity and clinical examination. In 10 of 16 eyes, preoperative and postoperative fluorescein angiography and optical coherence tomography were available. In the remaining 6 of 16 eyes, exudation was measured by postoperative clinical examination alone.
Three eyes (19%) showed a two-or-more-line improvement in visual acuity over a period of 6 to 25 months. Mean follow-up was 13 months. Visual acuity remained stable (no change or one-line improvement) in nine treated eyes (56%). The remaining four eyes (25%) showed a decline (equal to one-line worsening or greater) in visual acuity. Fifteen eyes (94%) demonstrated decreased exudation on fluorescein angiography, optical coherence tomography, and/or clinical examination.
Transpupillary thermotherapy shows no deleterious side effects in treating occult subfoveal choroidal neovascularization. A randomized, prospective study is necessary to evaluate treatment efficacy.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(99)90400-1</identifier><identifier>PMID: 10519584</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Choroidal Neovascularization - etiology ; Choroidal Neovascularization - pathology ; Choroidal Neovascularization - therapy ; Diseases of the eye ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Fovea Centralis ; Fundus Oculi ; Humans ; Hyperthermia, Induced ; Macular Degeneration - complications ; Macular Degeneration - pathology ; Male ; Medical sciences ; Pupil ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Tomography ; Treatment Outcome ; Visual Acuity</subject><ispartof>Ophthalmology (Rochester, Minn.), 1999-10, Vol.106 (10), p.1908-1914</ispartof><rights>1999 American Academy of Ophthalmology, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-11272adb792ca75c135b8ca3c7c60a31d882f2aab64e30b3182b2a48d80204303</citedby><cites>FETCH-LOGICAL-c390t-11272adb792ca75c135b8ca3c7c60a31d882f2aab64e30b3182b2a48d80204303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161642099904001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1991815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10519584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reichel, Elias</creatorcontrib><creatorcontrib>Berrocal, Audina M</creatorcontrib><creatorcontrib>Ip, Michael</creatorcontrib><creatorcontrib>Kroll, Arnold J</creatorcontrib><creatorcontrib>Desai, Vinay</creatorcontrib><creatorcontrib>Duker, Jay S</creatorcontrib><creatorcontrib>Puliafito, Carmen A</creatorcontrib><title>Transpupillary thermotherapy of occult subfoveal choroidal neovascularization in patients with age-related macular degeneration</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>To evaluate the efficacy of transpupillary thermotherapy for the treatment of occult subfoveal choroidal neovascularization (CNV) in patients with age-related macular degeneration.
A retrospective, noncomparative case series.
Sixteen eyes of 15 consecutive patients who presented with occult subfoveal choroidal neovascularization secondary to age-related macular degeneration.
After informed consent was obtained, 16 eyes of 15 patients were treated with transpupillary thermotherapy. All patients underwent pretreatment fluorescein angiography and were deemed untreatable by the Macular Photocoagulation Study standard. Transpupillary thermotherapy was delivered using a diode laser at 810 nm. A variable spot size of 1.2 mm, 2.0 mm, or 3.0 mm was used depending on the size of CNV. The diode laser was delivered through a contact lens, and treatment was initiated in one spot for 60 seconds’ duration at a power range between 360 and 1000 mW. The end point was an area of no visible color change to a light-gray appearance.
In all eyes, outcome was assessed by Snellen chart visual acuity and clinical examination. In 10 of 16 eyes, preoperative and postoperative fluorescein angiography and optical coherence tomography were available. In the remaining 6 of 16 eyes, exudation was measured by postoperative clinical examination alone.
Three eyes (19%) showed a two-or-more-line improvement in visual acuity over a period of 6 to 25 months. Mean follow-up was 13 months. Visual acuity remained stable (no change or one-line improvement) in nine treated eyes (56%). The remaining four eyes (25%) showed a decline (equal to one-line worsening or greater) in visual acuity. Fifteen eyes (94%) demonstrated decreased exudation on fluorescein angiography, optical coherence tomography, and/or clinical examination.
Transpupillary thermotherapy shows no deleterious side effects in treating occult subfoveal choroidal neovascularization. A randomized, prospective study is necessary to evaluate treatment efficacy.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Choroidal Neovascularization - etiology</subject><subject>Choroidal Neovascularization - pathology</subject><subject>Choroidal Neovascularization - therapy</subject><subject>Diseases of the eye</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Follow-Up Studies</subject><subject>Fovea Centralis</subject><subject>Fundus Oculi</subject><subject>Humans</subject><subject>Hyperthermia, Induced</subject><subject>Macular Degeneration - complications</subject><subject>Macular Degeneration - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pupil</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Tomography</subject><subject>Treatment Outcome</subject><subject>Visual Acuity</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1TAQRi0EoreFnwDyAqGyCPiVh1cVqnhJlVhQ1tbEnvQaJXGwnYvKhr-O70PAjs14JJ_P4zmEPOPsNWe8efOlFF41SrBLrV9pphir-AOy4bXSlWq5fEg2f5Azcp7SN8ZY00j1mJxxVnNdd2pDft1GmNOyLn4cId7TvMU4hX2F5Z6GgQZr1zHTtPZD2CGM1G5DDN6Vbsawg1SuIfqfkH2YqZ_pUjqcc6I_fN5SuMMq4ggZHZ3gwFKHdziXAfvEE_JogDHh09N5Qb6-f3d7_bG6-fzh0_Xbm8pKzXLFuWgFuL7VwkJbWy7rvrMgbWsbBpK7rhODAOgbhZL1kneiF6A61zHBlGTygrw8vrvE8H3FlM3kk8WydNliTaZlnRJayQLWR9DGkFLEwSzRT0WN4czszZuDebPXarQ2B_OGl9zz04C1n9D9kzqqLsCLE1CcwTgU79anv5zWvON1wa6OGBYbO4_RJFt8WnQ-os3GBf-fn_wGox6i9A</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Reichel, Elias</creator><creator>Berrocal, Audina M</creator><creator>Ip, Michael</creator><creator>Kroll, Arnold J</creator><creator>Desai, Vinay</creator><creator>Duker, Jay S</creator><creator>Puliafito, Carmen A</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Transpupillary thermotherapy of occult subfoveal choroidal neovascularization in patients with age-related macular degeneration</title><author>Reichel, Elias ; Berrocal, Audina M ; Ip, Michael ; Kroll, Arnold J ; Desai, Vinay ; Duker, Jay S ; Puliafito, Carmen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-11272adb792ca75c135b8ca3c7c60a31d882f2aab64e30b3182b2a48d80204303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Choroidal Neovascularization - etiology</topic><topic>Choroidal Neovascularization - pathology</topic><topic>Choroidal Neovascularization - therapy</topic><topic>Diseases of the eye</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Follow-Up Studies</topic><topic>Fovea Centralis</topic><topic>Fundus Oculi</topic><topic>Humans</topic><topic>Hyperthermia, Induced</topic><topic>Macular Degeneration - complications</topic><topic>Macular Degeneration - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pupil</topic><topic>Radiotherapy. 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Diet therapy and various other treatments (general aspects)</topic><topic>Tomography</topic><topic>Treatment Outcome</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reichel, Elias</creatorcontrib><creatorcontrib>Berrocal, Audina M</creatorcontrib><creatorcontrib>Ip, Michael</creatorcontrib><creatorcontrib>Kroll, Arnold J</creatorcontrib><creatorcontrib>Desai, Vinay</creatorcontrib><creatorcontrib>Duker, Jay S</creatorcontrib><creatorcontrib>Puliafito, Carmen A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reichel, Elias</au><au>Berrocal, Audina M</au><au>Ip, Michael</au><au>Kroll, Arnold J</au><au>Desai, Vinay</au><au>Duker, Jay S</au><au>Puliafito, Carmen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transpupillary thermotherapy of occult subfoveal choroidal neovascularization in patients with age-related macular degeneration</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>106</volume><issue>10</issue><spage>1908</spage><epage>1914</epage><pages>1908-1914</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>To evaluate the efficacy of transpupillary thermotherapy for the treatment of occult subfoveal choroidal neovascularization (CNV) in patients with age-related macular degeneration.
A retrospective, noncomparative case series.
Sixteen eyes of 15 consecutive patients who presented with occult subfoveal choroidal neovascularization secondary to age-related macular degeneration.
After informed consent was obtained, 16 eyes of 15 patients were treated with transpupillary thermotherapy. All patients underwent pretreatment fluorescein angiography and were deemed untreatable by the Macular Photocoagulation Study standard. Transpupillary thermotherapy was delivered using a diode laser at 810 nm. A variable spot size of 1.2 mm, 2.0 mm, or 3.0 mm was used depending on the size of CNV. The diode laser was delivered through a contact lens, and treatment was initiated in one spot for 60 seconds’ duration at a power range between 360 and 1000 mW. The end point was an area of no visible color change to a light-gray appearance.
In all eyes, outcome was assessed by Snellen chart visual acuity and clinical examination. In 10 of 16 eyes, preoperative and postoperative fluorescein angiography and optical coherence tomography were available. In the remaining 6 of 16 eyes, exudation was measured by postoperative clinical examination alone.
Three eyes (19%) showed a two-or-more-line improvement in visual acuity over a period of 6 to 25 months. Mean follow-up was 13 months. Visual acuity remained stable (no change or one-line improvement) in nine treated eyes (56%). The remaining four eyes (25%) showed a decline (equal to one-line worsening or greater) in visual acuity. Fifteen eyes (94%) demonstrated decreased exudation on fluorescein angiography, optical coherence tomography, and/or clinical examination.
Transpupillary thermotherapy shows no deleterious side effects in treating occult subfoveal choroidal neovascularization. A randomized, prospective study is necessary to evaluate treatment efficacy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10519584</pmid><doi>10.1016/S0161-6420(99)90400-1</doi><tpages>7</tpages></addata></record> |
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| ispartof | Ophthalmology (Rochester, Minn.), 1999-10, Vol.106 (10), p.1908-1914 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Biological and medical sciences Choroidal Neovascularization - etiology Choroidal Neovascularization - pathology Choroidal Neovascularization - therapy Diseases of the eye Female Fluorescein Angiography Follow-Up Studies Fovea Centralis Fundus Oculi Humans Hyperthermia, Induced Macular Degeneration - complications Macular Degeneration - pathology Male Medical sciences Pupil Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Tomography Treatment Outcome Visual Acuity |
| title | Transpupillary thermotherapy of occult subfoveal choroidal neovascularization in patients with age-related macular degeneration |
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