Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects

OBJECTIVE: Abnormalities in dopamine neurotransmission in the prefrontal cortex have been implicated in the pathophysiology of schizophrenia. However, the integrity of the dopamine projections to the prefrontal cortex in this disorder has not been directly examined. METHOD: The authors employed immu...

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Veröffentlicht in:	The American journal of psychiatry 1999-10, Vol.156 (10), p.1580-1589
Hauptverfasser:	Akil, Mayada, Pierri, Joseph N., Whitehead, Richard E., Edgar, Christine L., Mohila, Carrie, Sampson, Allan R., Lewis, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Aged Animals Axons - enzymology Axons - metabolism Biological and medical sciences Carrier Proteins - metabolism Delayed-Action Preparations Dopamine - immunology Dopamine - metabolism Dopamine - physiology Dopamine Plasma Membrane Transport Proteins Female Haloperidol - pharmacology Humans Immunohistochemistry Macaca fascicularis Male Medical sciences Membrane Glycoproteins - metabolism Membrane Transport Proteins Middle Aged Nerve Tissue Proteins Neurology Prefrontal Cortex - enzymology Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - metabolism Schizophrenia - physiopathology Serotonin Plasma Membrane Transport Proteins Synaptic Transmission - physiology Tyrosine 3-Monooxygenase - immunology Tyrosine 3-Monooxygenase - metabolism
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