Effect of Environmental Factors on the Kinetics of Insulin Fibril Formation: Elucidation of the Molecular Mechanism

In the search for the molecular mechanism of insulin fibrillation, the kinetics of insulin fibril formation were studied under different conditions using the fluorescent dye thioflavin T (ThT). The effect of insulin concentration, agitation, pH, ionic strength, anions, seeding, and addition of 1-ani...

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Veröffentlicht in:	Biochem.40:6036,2001 2001, 2001-05, Vol.40 (20), p.6036-6046
Hauptverfasser:	Nielsen, Liza, Khurana, Ritu, Coats, Alisa, Frokjaer, Sven, Brange, Jens, Vyas, Sandip, Uversky, Vladimir N, Fink, Anthony L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilino Naphthalenesulfonates - chemistry Animals Anions - chemistry Cattle Chemistry, Physical - methods Excipients - chemistry Fluorescent Dyes - chemistry Hydrogen-Ion Concentration INSULIN Insulin - chemistry Insulin - metabolism KINETICS Methylamines - chemistry Models, Chemical Osmolar Concentration PARTICLE ACCELERATORS Protein Denaturation Salts - chemistry Sonication STANFORD LINEAR ACCELERATOR CENTER STANFORD SYNCHROTRON RADIATION LABORATORY Sucrose - chemistry Surface Properties SYNCHROTRON RADIATION Thiazoles - chemistry Urea - chemistry
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