Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis

Mutations of the glucokinase gene cause hyperglycaemia or hypoglycaemia. A quantitative understanding of these defects of glucose homeostasis linked to the glucokinase gene was lacking. Therefore a database of kinetic variables of wild-type and 20 missense mutants of glucokinase was developed and us...

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Veröffentlicht in:	Diabetologia 1999-10, Vol.42 (10), p.1175-1186
Hauptverfasser:	DAVIS, E. A, CUESTA-MUNOZ, A, RAOUL, M, BUETTGER, C, SWEET, I, MOATES, M, MAGNUSON, M. A, MATSCHINSKY, F. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adenosine Triphosphate - metabolism Biological and medical sciences Biophysics Blood Glucose - metabolism Carrier Proteins Diabetes Endocrine pancreas Enzyme Activation - drug effects Enzyme Activation - genetics Enzyme Stability Fundamental and applied biological sciences. Psychology Glucokinase - antagonists & inhibitors Glucokinase - genetics Glucokinase - metabolism Glucose Glucose - pharmacology Glucose - physiology Glutathione Transferase - genetics Homeostasis Hormones. Régulation Humans Hyperglycemia Hyperglycemia - blood Hyperglycemia - genetics Hypoglycemia Hypoglycemia - blood Hypoglycemia - genetics Insulin Insulin - blood Kinetics Mathematical models Models, Biological Mutation Phosphorylation Physiology Proteins Proteins - pharmacology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - isolation & purification Recombinant Fusion Proteins - metabolism Sensors Syndrome Vertebrates: endocrinology
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