The Effects of Donepezil on the P300 Auditory and Visual Cognitive Evoked Potentials of Patients With Alzheimer's Disease
Donepezil is a cholinesterase inhibitor used for the treatment of patients with mild to moderately severe Alzheimer's disease (AD). The purpose of this study was to determine the effect of treatment with donepezil 5 mg qd on cognitive evoked potentials (EPs) of patients with AD. Although treatm...
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| Veröffentlicht in: | The American journal of geriatric psychiatry 1999, Vol.7 (4), p.349-352 |
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| container_end_page | 352 |
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| container_title | The American journal of geriatric psychiatry |
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| creator | Reeves, Roy R. Struve, Frederick A. Patrick, Gloria Booker, J. Gary Nave, Dennis W. |
| description | Donepezil is a cholinesterase inhibitor used for the treatment of patients with mild to moderately severe Alzheimer's disease (AD). The purpose of this study was to determine the effect of treatment with donepezil 5 mg qd on cognitive evoked potentials (EPs) of patients with AD. Although treatment with donepezil did not normalize EP latencies, treatment was associated with a significant decrease in the auditory P300 latency (mean latency pretreatment=401.5 msec; posttreatment=392.7 msec.; P=0.04), and the visual P300 latency (mean latency pretreatment=605.7 msec; posttreatment=580.3 msec; P=0.04). Treatment with donepezil had no discernible effect on auditory or visual P300 EP amplitudes. |
| doi_str_mv | 10.1097/00019442-199911000-00012 |
| format | Article |
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Treatment with donepezil had no discernible effect on auditory or visual P300 EP amplitudes.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Cholinesterase Inhibitors - therapeutic use</subject><subject>Event-Related Potentials, P300 - drug effects</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Evoked Potentials, Visual - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Indans - therapeutic use</subject><subject>Male</subject><subject>Nootropic Agents - therapeutic use</subject><subject>Piperidines - therapeutic use</subject><subject>Refractory Period, Electrophysiological - drug effects</subject><issn>1064-7481</issn><issn>1545-7214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v3CAQQFHVqknT_IWIU3tyy9gYw3G7ST-kSNlD2hwRhnGW1mu2gFfa_PqQbFrllhPMzJsZzSOEAvsETHWfGWOgOK8rUEoBlLB6SNWvyDG0vK26Gvjr8meCVx2XcETepfS7IEIJ_pYcAWtrAKGOyf56jfRiGNDmRMNAz8OEW7zzIw0TzaW2ahiji9n5HOKemsnRXz7NZqTLcDv57HelfRf-oKOrkHHK3oyPg1Ym-xImeuPzmi7GuzX6DcaPiZ77hCbhe_JmKCyePr0n5OfXi-vl9-ry6tuP5eKysk3HctXzujbCgbFgpHWtEWiVqJnFrhzQcyFdKyV3xlrgnWqwZ62RQgBK1vTcNifkw2HuNoa_M6asNz5ZHEczYZiT7phspGqhgPIA2hhSijjobfQbE_camH7Qrv9p1_-1P6bq0nr2tGPuN-ieNR48F-DLAcBy6c5j1MkWPRadj0W9dsG_vOUeaRKRsQ</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Reeves, Roy R.</creator><creator>Struve, Frederick A.</creator><creator>Patrick, Gloria</creator><creator>Booker, J. 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Gary</creatorcontrib><creatorcontrib>Nave, Dennis W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reeves, Roy R.</au><au>Struve, Frederick A.</au><au>Patrick, Gloria</au><au>Booker, J. Gary</au><au>Nave, Dennis W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Donepezil on the P300 Auditory and Visual Cognitive Evoked Potentials of Patients With Alzheimer's Disease</atitle><jtitle>The American journal of geriatric psychiatry</jtitle><addtitle>Am J Geriatr Psychiatry</addtitle><date>1999</date><risdate>1999</risdate><volume>7</volume><issue>4</issue><spage>349</spage><epage>352</epage><pages>349-352</pages><issn>1064-7481</issn><eissn>1545-7214</eissn><abstract>Donepezil is a cholinesterase inhibitor used for the treatment of patients with mild to moderately severe Alzheimer's disease (AD). The purpose of this study was to determine the effect of treatment with donepezil 5 mg qd on cognitive evoked potentials (EPs) of patients with AD. Although treatment with donepezil did not normalize EP latencies, treatment was associated with a significant decrease in the auditory P300 latency (mean latency pretreatment=401.5 msec; posttreatment=392.7 msec.; P=0.04), and the visual P300 latency (mean latency pretreatment=605.7 msec; posttreatment=580.3 msec; P=0.04). Treatment with donepezil had no discernible effect on auditory or visual P300 EP amplitudes.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>10521169</pmid><doi>10.1097/00019442-199911000-00012</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1064-7481 |
| ispartof | The American journal of geriatric psychiatry, 1999, Vol.7 (4), p.349-352 |
| issn | 1064-7481 1545-7214 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Alzheimer Disease - drug therapy Alzheimer Disease - physiopathology Cholinesterase Inhibitors - therapeutic use Event-Related Potentials, P300 - drug effects Evoked Potentials, Auditory - drug effects Evoked Potentials, Visual - drug effects Female Humans Indans - therapeutic use Male Nootropic Agents - therapeutic use Piperidines - therapeutic use Refractory Period, Electrophysiological - drug effects |
| title | The Effects of Donepezil on the P300 Auditory and Visual Cognitive Evoked Potentials of Patients With Alzheimer's Disease |
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