Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κB
Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia (ATL), as well as for tropical spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM). A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings...
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| Veröffentlicht in: | Cytokine & growth factor reviews 2001-06, Vol.12 (2), p.207-217 |
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| description | Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia (ATL), as well as for tropical spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM). A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings of the virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a transcriptional activator. Its ability to modulate the expression and function of many cellular genes has been reasoned to be a major contributory mechanism explaining HTLV-I-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB/ATF and NF-κB. In this paper, we review aspects of Tax's transcriptional potential with particular focus on recent evidence linking Tax to IKK (IκB-kinase)-complex and MAP3Ks (mitogen-activated protein kinase kinase kinases). |
| doi_str_mv | 10.1016/S1359-6101(00)00028-9 |
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In this paper, we review aspects of Tax's transcriptional potential with particular focus on recent evidence linking Tax to IKK (IκB-kinase)-complex and MAP3Ks (mitogen-activated protein kinase kinase kinases).</description><subject>Adult T-cell leukemia</subject><subject>Animals</subject><subject>AP-1</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cellular transformation</subject><subject>CREB</subject><subject>Cytoplasm - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Gene Products, tax - chemistry</subject><subject>Gene Products, tax - metabolism</subject><subject>HAM/TSP</subject><subject>HTLV</subject><subject>human T-lymphotropic virus 1</subject><subject>Human T-lymphotropic virus 1 - metabolism</subject><subject>Humans</subject><subject>I-kappa B Kinase</subject><subject>Leukemia-Lymphoma, Adult T-Cell - metabolism</subject><subject>Leukemia-Lymphoma, Adult T-Cell - pathology</subject><subject>Leukemia-Lymphoma, Adult T-Cell - 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A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings of the virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a transcriptional activator. Its ability to modulate the expression and function of many cellular genes has been reasoned to be a major contributory mechanism explaining HTLV-I-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB/ATF and NF-κB. In this paper, we review aspects of Tax's transcriptional potential with particular focus on recent evidence linking Tax to IKK (IκB-kinase)-complex and MAP3Ks (mitogen-activated protein kinase kinase kinases).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11325603</pmid><doi>10.1016/S1359-6101(00)00028-9</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult T-cell leukemia Animals AP-1 Cell Nucleus - metabolism Cell Transformation, Neoplastic - metabolism Cellular transformation CREB Cytoplasm - metabolism Gene Expression Regulation Gene Products, tax - chemistry Gene Products, tax - metabolism HAM/TSP HTLV human T-lymphotropic virus 1 Human T-lymphotropic virus 1 - metabolism Humans I-kappa B Kinase Leukemia-Lymphoma, Adult T-Cell - metabolism Leukemia-Lymphoma, Adult T-Cell - pathology Leukemia-Lymphoma, Adult T-Cell - virology MAP kinase kinase kinase MAP Kinase Kinase Kinases - metabolism NF-kappa B - metabolism NF-κB Protein-Serine-Threonine Kinases - metabolism Signal Transduction Tax Transcription Factors - metabolism |
| title | Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κB |
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