Amyloid beta peptide 25-35 modulates hydrolysis of phosphoinositides by membrane phospholipase(s) C of adult brain cortex

Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in signal transduction. A subset of muscarinic cholinergic receptors are linked to G-proteins that activate phospholipase C. Cholinergic pathways are important in learning and memory, and deficits in cholinergic transmission have been i...

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Veröffentlicht in:	Journal of molecular neuroscience 1999-04, Vol.12 (2), p.101-109
Hauptverfasser:	Strosznajder, J B, Zambrzycka, A, Kacprzak, M D, Strosznajder, R P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Acetylcholine receptors (muscarinic) Age Factors Agonists Alzheimer's disease Amyloid beta-Peptides - pharmacology Animals Brain Calcium chloride Calcium Chloride - pharmacology Calcium ions Carbachol Cell Membrane - drug effects Cell Membrane - enzymology Cerebral Cortex - enzymology Cholinergic transmission Cholinergics Cytosol Cytosol - drug effects Cytosol - enzymology Degradation Enzyme Activation - drug effects Enzyme Activation - physiology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Hydrolysis Inositol 1,4,5-trisphosphate receptors Inositol trisphosphate Inositols Membranes Neurodegenerative diseases Peptide Fragments - pharmacology Peptides Phosphatidylinositol 4,5-diphosphate Phosphatidylinositols - metabolism Phosphoinositides Phospholipase Phospholipase C Phospholipids Plasma membranes Proteins Rats Rats, Wistar Receptors Rodents Signal transduction Signal Transduction - physiology Synaptic Membranes - drug effects Synaptic Membranes - enzymology Type C Phospholipases - metabolism β-Amyloid
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