The connective-tissue envelope in revascularisation of patellar tendon grafts
Free patellar tendon grafts used for the intra-articular replacement of ruptured anterior cruciate ligaments (ACL) lack perfusion at the time of implantation. The central core of the graft undergoes a process of ischaemic necrosis which may result in failure. Early reperfusion of the graft may dimin...
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| Veröffentlicht in: | Journal of bone and joint surgery. British volume 1999-09, Vol.81 (5), p.915-920 |
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| container_title | Journal of bone and joint surgery. British volume |
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| creator | SCKELL, A LEUNIG, M FRAITZL, C. R GANZ, R BALLMER, F. T |
| description | Free patellar tendon grafts used for the intra-articular replacement of ruptured anterior cruciate ligaments (ACL) lack perfusion at the time of implantation. The central core of the graft undergoes a process of ischaemic necrosis which may result in failure. Early reperfusion of the graft may diminish the extent of this process. We assessed the role of peritendinous connective tissue in the revascularisation of the patellar tendon graft from the day of implantation up to 24 days in a murine model using intravital microscopy. The peritendinous connective-tissue envelope of the graft was either completely removed, partially removed or not stripped before implantation into dorsal skinfold chambers of recipient mice. Initial revascularisation of the grafts with preserved peritendinous connective tissues began after two days. The process was delayed by five to six times in completely stripped patellar tendons (p < 0.05). Only grafts with preserved connective tissues showed high viability whereas those which were completely stripped appeared to be subvital. The presence of peritendinous connective tissues accelerates the revascularisation of free patellar tendon grafts. |
| doi_str_mv | 10.1302/0301-620X.81B5.0810915 |
| format | Article |
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R ; GANZ, R ; BALLMER, F. T</creator><creatorcontrib>SCKELL, A ; LEUNIG, M ; FRAITZL, C. R ; GANZ, R ; BALLMER, F. T</creatorcontrib><description>Free patellar tendon grafts used for the intra-articular replacement of ruptured anterior cruciate ligaments (ACL) lack perfusion at the time of implantation. The central core of the graft undergoes a process of ischaemic necrosis which may result in failure. Early reperfusion of the graft may diminish the extent of this process. We assessed the role of peritendinous connective tissue in the revascularisation of the patellar tendon graft from the day of implantation up to 24 days in a murine model using intravital microscopy. The peritendinous connective-tissue envelope of the graft was either completely removed, partially removed or not stripped before implantation into dorsal skinfold chambers of recipient mice. Initial revascularisation of the grafts with preserved peritendinous connective tissues began after two days. The process was delayed by five to six times in completely stripped patellar tendons (p < 0.05). Only grafts with preserved connective tissues showed high viability whereas those which were completely stripped appeared to be subvital. The presence of peritendinous connective tissues accelerates the revascularisation of free patellar tendon grafts.</description><edition>British volume</edition><identifier>ISSN: 0301-620X</identifier><identifier>ISSN: 2049-4394</identifier><identifier>EISSN: 2044-5377</identifier><identifier>EISSN: 2049-4408</identifier><identifier>DOI: 10.1302/0301-620X.81B5.0810915</identifier><identifier>PMID: 10530862</identifier><identifier>CODEN: JBSUAK</identifier><language>eng</language><publisher>London: British Editorial Society of Bone and Joint Surgery</publisher><subject>Animals ; Anterior Cruciate Ligament - surgery ; Anterior Cruciate Ligament Injuries ; Biological and medical sciences ; Connective Tissue - transplantation ; Dermatologic Surgical Procedures ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Mice ; Microscopy, Video ; Muscle, Skeletal - surgery ; Necrosis ; Neovascularization, Physiologic - physiology ; Osteoarticular system. Muscles ; Patella - blood supply ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Rupture ; Tendons - blood supply ; Tendons - pathology ; Tendons - transplantation</subject><ispartof>Journal of bone and joint surgery. 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R</creatorcontrib><creatorcontrib>GANZ, R</creatorcontrib><creatorcontrib>BALLMER, F. T</creatorcontrib><title>The connective-tissue envelope in revascularisation of patellar tendon grafts</title><title>Journal of bone and joint surgery. British volume</title><addtitle>J Bone Joint Surg Br</addtitle><description>Free patellar tendon grafts used for the intra-articular replacement of ruptured anterior cruciate ligaments (ACL) lack perfusion at the time of implantation. The central core of the graft undergoes a process of ischaemic necrosis which may result in failure. Early reperfusion of the graft may diminish the extent of this process. We assessed the role of peritendinous connective tissue in the revascularisation of the patellar tendon graft from the day of implantation up to 24 days in a murine model using intravital microscopy. The peritendinous connective-tissue envelope of the graft was either completely removed, partially removed or not stripped before implantation into dorsal skinfold chambers of recipient mice. Initial revascularisation of the grafts with preserved peritendinous connective tissues began after two days. The process was delayed by five to six times in completely stripped patellar tendons (p < 0.05). Only grafts with preserved connective tissues showed high viability whereas those which were completely stripped appeared to be subvital. The presence of peritendinous connective tissues accelerates the revascularisation of free patellar tendon grafts.</description><subject>Animals</subject><subject>Anterior Cruciate Ligament - surgery</subject><subject>Anterior Cruciate Ligament Injuries</subject><subject>Biological and medical sciences</subject><subject>Connective Tissue - transplantation</subject><subject>Dermatologic Surgical Procedures</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microscopy, Video</subject><subject>Muscle, Skeletal - surgery</subject><subject>Necrosis</subject><subject>Neovascularization, Physiologic - physiology</subject><subject>Osteoarticular system. Muscles</subject><subject>Patella - blood supply</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Rupture</subject><subject>Tendons - blood supply</subject><subject>Tendons - pathology</subject><subject>Tendons - transplantation</subject><issn>0301-620X</issn><issn>2049-4394</issn><issn>2044-5377</issn><issn>2049-4408</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLw0AUhQdRtFb_Qgki7lLvPDNZavEFFTcV3A3TyY2mpJM6kxT89ya0qLi6cPjO4fIRMqEwpRzYNXCgqWLwNtX0Vk5BU8ipPCAjBkKkkmfZIRn9QCfkNMYVAAgp-TE5oSA5aMVG5HnxgYlrvEfXVltM2yrGDhP0W6ybDSaVTwJubXRdbUMVbVs1PmnKZGNbrPsoadEXffQebNnGM3JU2jri-f6Oyev93WL2mM5fHp5mN_PUMQosZUqzXEMhrC4QuJJL4eSSatAOtRVlqYqMMotOyQyWwHOqKINSK5lbR13Gx-Rqt7sJzWeHsTXrKrrhIY9NF00GmmdMsB68-Aeumi74_jfDWK6UFAJ6SO0gF5oYA5ZmE6q1DV-Gghlsm0GkGUSawbbZ2-6Lk_16t1xj8ae209sDl3ugN2jrMljvqvjL5ULnmebfZK6Glw</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>SCKELL, A</creator><creator>LEUNIG, M</creator><creator>FRAITZL, C. 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British volume</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCKELL, A</au><au>LEUNIG, M</au><au>FRAITZL, C. R</au><au>GANZ, R</au><au>BALLMER, F. T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The connective-tissue envelope in revascularisation of patellar tendon grafts</atitle><jtitle>Journal of bone and joint surgery. British volume</jtitle><addtitle>J Bone Joint Surg Br</addtitle><date>1999-09</date><risdate>1999</risdate><volume>81</volume><issue>5</issue><spage>915</spage><epage>920</epage><pages>915-920</pages><issn>0301-620X</issn><issn>2049-4394</issn><eissn>2044-5377</eissn><eissn>2049-4408</eissn><coden>JBSUAK</coden><abstract>Free patellar tendon grafts used for the intra-articular replacement of ruptured anterior cruciate ligaments (ACL) lack perfusion at the time of implantation. The central core of the graft undergoes a process of ischaemic necrosis which may result in failure. Early reperfusion of the graft may diminish the extent of this process. We assessed the role of peritendinous connective tissue in the revascularisation of the patellar tendon graft from the day of implantation up to 24 days in a murine model using intravital microscopy. The peritendinous connective-tissue envelope of the graft was either completely removed, partially removed or not stripped before implantation into dorsal skinfold chambers of recipient mice. Initial revascularisation of the grafts with preserved peritendinous connective tissues began after two days. The process was delayed by five to six times in completely stripped patellar tendons (p < 0.05). Only grafts with preserved connective tissues showed high viability whereas those which were completely stripped appeared to be subvital. The presence of peritendinous connective tissues accelerates the revascularisation of free patellar tendon grafts.</abstract><cop>London</cop><pub>British Editorial Society of Bone and Joint Surgery</pub><pmid>10530862</pmid><doi>10.1302/0301-620X.81B5.0810915</doi><tpages>6</tpages><edition>British volume</edition></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Anterior Cruciate Ligament - surgery Anterior Cruciate Ligament Injuries Biological and medical sciences Connective Tissue - transplantation Dermatologic Surgical Procedures Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mice Microscopy, Video Muscle, Skeletal - surgery Necrosis Neovascularization, Physiologic - physiology Osteoarticular system. Muscles Patella - blood supply Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rupture Tendons - blood supply Tendons - pathology Tendons - transplantation |
| title | The connective-tissue envelope in revascularisation of patellar tendon grafts |
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