Subacute encephalopathy in a 5-year-old boy
A 5-year-old boy presented with an acute ataxia and altered mental status. Although he initially recovered from these symptoms, he presented a second time with myoclonus and seizures and rapidly became vegetative. Cerebrospinal fluid studies, magnetic resonance imaging, and brain biopsy all confirme...
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| Veröffentlicht in: | Seminars in pediatric neurology 1999-09, Vol.6 (3), p.168-172 |
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| container_title | Seminars in pediatric neurology |
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| creator | Bobele, Gary B. Bale, James F. |
| description | A 5-year-old boy presented with an acute ataxia and altered mental status. Although he initially recovered from these symptoms, he presented a second time with myoclonus and seizures and rapidly became vegetative. Cerebrospinal fluid studies, magnetic resonance imaging, and brain biopsy all confirmed the presence of subacute sclerosing panencephalitis. Despite courses of therapy with cimetidine, amantadine, ribavirin, and inosine, no clinical improvement has been seen. Clinicians need to be alert to the possibility of subacute sclerosing panencephalitis even in the vaccinated child in the appropriate clinical setting. |
| doi_str_mv | 10.1016/S1071-9091(99)80008-4 |
| format | Article |
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Although he initially recovered from these symptoms, he presented a second time with myoclonus and seizures and rapidly became vegetative. Cerebrospinal fluid studies, magnetic resonance imaging, and brain biopsy all confirmed the presence of subacute sclerosing panencephalitis. Despite courses of therapy with cimetidine, amantadine, ribavirin, and inosine, no clinical improvement has been seen. Clinicians need to be alert to the possibility of subacute sclerosing panencephalitis even in the vaccinated child in the appropriate clinical setting.</description><identifier>ISSN: 1071-9091</identifier><identifier>EISSN: 1558-0776</identifier><identifier>DOI: 10.1016/S1071-9091(99)80008-4</identifier><identifier>PMID: 10522334</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute Disease ; Adrenal Cortex Hormones - therapeutic use ; Anticonvulsants - therapeutic use ; Ataxia - diagnosis ; Ataxia - drug therapy ; Ataxia - etiology ; Biopsy ; Brain - pathology ; Child, Preschool ; Electroencephalography ; Epilepsies, Myoclonic - diagnosis ; Epilepsies, Myoclonic - drug therapy ; Epilepsies, Myoclonic - etiology ; Humans ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Male ; Measles - prevention & control ; Measles Vaccine - adverse effects ; Persistent Vegetative State - diagnosis ; Persistent Vegetative State - etiology ; Severity of Illness Index ; Subacute Sclerosing Panencephalitis - complications ; Subacute Sclerosing Panencephalitis - diagnosis ; Subacute Sclerosing Panencephalitis - virology</subject><ispartof>Seminars in pediatric neurology, 1999-09, Vol.6 (3), p.168-172</ispartof><rights>1999 W.B. 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Although he initially recovered from these symptoms, he presented a second time with myoclonus and seizures and rapidly became vegetative. Cerebrospinal fluid studies, magnetic resonance imaging, and brain biopsy all confirmed the presence of subacute sclerosing panencephalitis. Despite courses of therapy with cimetidine, amantadine, ribavirin, and inosine, no clinical improvement has been seen. Clinicians need to be alert to the possibility of subacute sclerosing panencephalitis even in the vaccinated child in the appropriate clinical setting.</description><subject>Acute Disease</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Ataxia - diagnosis</subject><subject>Ataxia - drug therapy</subject><subject>Ataxia - etiology</subject><subject>Biopsy</subject><subject>Brain - pathology</subject><subject>Child, Preschool</subject><subject>Electroencephalography</subject><subject>Epilepsies, Myoclonic - diagnosis</subject><subject>Epilepsies, Myoclonic - drug therapy</subject><subject>Epilepsies, Myoclonic - etiology</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Male</subject><subject>Measles - prevention & control</subject><subject>Measles Vaccine - adverse effects</subject><subject>Persistent Vegetative State - diagnosis</subject><subject>Persistent Vegetative State - etiology</subject><subject>Severity of Illness Index</subject><subject>Subacute Sclerosing Panencephalitis - complications</subject><subject>Subacute Sclerosing Panencephalitis - diagnosis</subject><subject>Subacute Sclerosing Panencephalitis - virology</subject><issn>1071-9091</issn><issn>1558-0776</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN9LwzAQgIMobk7_BKVPokj00iZp8iQy_AUDH6bPIUuurNKtM2mF_vd26wTffLo77rs77iPknMEtAybv5gxyRjVodqX1tQIARfkBGTMhFIU8l4d9_ouMyEmMnwAZ76tjMmIg0jTL-JjczNuFdW2DCa4dbpa2qje2WXZJuU5sImiHNtC68smi7k7JUWGriGf7OCEfT4_v0xc6e3t-nT7MqMtS1VBvtcy54qkunC9k7oXUKAqlpPCp1Ra8cqLoG-jyIkOruCw8QyUY9AvAZhNyOezdhPqrxdiYVRkdVpVdY91Gk4PKpOTQg2IAXahjDFiYTShXNnSGgdlaMjtLZqvAaG12lgzv5y72B9rFCv2fqUFLD9wPAPZvfpcYTHTlVpAvA7rG-Lr858QPuWZ1gw</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>Bobele, Gary B.</creator><creator>Bale, James F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>Subacute encephalopathy in a 5-year-old boy</title><author>Bobele, Gary B. ; Bale, James F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-da96748429fcdf67d569e5f8865d2a9a0d8c5ff67ec7f3ea846fd1e8510c320a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acute Disease</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Ataxia - diagnosis</topic><topic>Ataxia - drug therapy</topic><topic>Ataxia - etiology</topic><topic>Biopsy</topic><topic>Brain - pathology</topic><topic>Child, Preschool</topic><topic>Electroencephalography</topic><topic>Epilepsies, Myoclonic - diagnosis</topic><topic>Epilepsies, Myoclonic - drug therapy</topic><topic>Epilepsies, Myoclonic - etiology</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>Male</topic><topic>Measles - prevention & control</topic><topic>Measles Vaccine - adverse effects</topic><topic>Persistent Vegetative State - diagnosis</topic><topic>Persistent Vegetative State - etiology</topic><topic>Severity of Illness Index</topic><topic>Subacute Sclerosing Panencephalitis - complications</topic><topic>Subacute Sclerosing Panencephalitis - diagnosis</topic><topic>Subacute Sclerosing Panencephalitis - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bobele, Gary B.</creatorcontrib><creatorcontrib>Bale, James F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in pediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bobele, Gary B.</au><au>Bale, James F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subacute encephalopathy in a 5-year-old boy</atitle><jtitle>Seminars in pediatric neurology</jtitle><addtitle>Semin Pediatr Neurol</addtitle><date>1999-09</date><risdate>1999</risdate><volume>6</volume><issue>3</issue><spage>168</spage><epage>172</epage><pages>168-172</pages><issn>1071-9091</issn><eissn>1558-0776</eissn><abstract>A 5-year-old boy presented with an acute ataxia and altered mental status. Although he initially recovered from these symptoms, he presented a second time with myoclonus and seizures and rapidly became vegetative. Cerebrospinal fluid studies, magnetic resonance imaging, and brain biopsy all confirmed the presence of subacute sclerosing panencephalitis. Despite courses of therapy with cimetidine, amantadine, ribavirin, and inosine, no clinical improvement has been seen. Clinicians need to be alert to the possibility of subacute sclerosing panencephalitis even in the vaccinated child in the appropriate clinical setting.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10522334</pmid><doi>10.1016/S1071-9091(99)80008-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-9091 |
| ispartof | Seminars in pediatric neurology, 1999-09, Vol.6 (3), p.168-172 |
| issn | 1071-9091 1558-0776 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute Disease Adrenal Cortex Hormones - therapeutic use Anticonvulsants - therapeutic use Ataxia - diagnosis Ataxia - drug therapy Ataxia - etiology Biopsy Brain - pathology Child, Preschool Electroencephalography Epilepsies, Myoclonic - diagnosis Epilepsies, Myoclonic - drug therapy Epilepsies, Myoclonic - etiology Humans Immunoglobulin G - blood Immunoglobulin M - blood Male Measles - prevention & control Measles Vaccine - adverse effects Persistent Vegetative State - diagnosis Persistent Vegetative State - etiology Severity of Illness Index Subacute Sclerosing Panencephalitis - complications Subacute Sclerosing Panencephalitis - diagnosis Subacute Sclerosing Panencephalitis - virology |
| title | Subacute encephalopathy in a 5-year-old boy |
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