Peritoneal washing cytology: Prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection
Background and Objectives Free cancer cells in the abdominal cavity exfoliated from a tumor are considered to be responsible for peritoneal dissemination, the most frequent pattern of failure in gastric carcinoma patients treated with curative surgery. Methods A prospective survival analysis was per...
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| Veröffentlicht in: | Journal of surgical oncology 1999-10, Vol.72 (2), p.60-64 |
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| container_title | Journal of surgical oncology |
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| creator | Kodera, Yasuhiro Yamamura, Yoshitaka Shimizu, Yasuhiro Torii, Akihito Hirai, Takashi Yasui, Kenzo Morimoto, Takeshi Kato, Tomoyuki |
| description | Background and Objectives
Free cancer cells in the abdominal cavity exfoliated from a tumor are considered to be responsible for peritoneal dissemination, the most frequent pattern of failure in gastric carcinoma patients treated with curative surgery.
Methods
A prospective survival analysis was performed with 91 gastric carcinoma patients treated by potentially curative resection. Cytology was performed for all the patients. The method of Kaplan and Meier was used to construct curves with diagnosis of peritoneal dissemination and cancer death as the end points. Multivariate analysis by Cox's proportional hazards model was performed to identify independent prognostic factors of significance.
Results
Patients with a positive cytology result were confirmed to have a greater risk for recurrence in the pattern of peritoneal carcinomatosis and hence a significantly inferior prognosis. Positive cytology was the only significant independent prognostic factor among the curatively resected patients with advanced gastric carcinoma.
Conclusions
Peritoneal lavage cytology should be employed for all advanced cancer undergoing potentially curative resection for added accuracy in the stage classification. The results should also reflect the eligibility of the patients for future clinical trials involving perioperative intraperitoneal chemotherapy. J. Surg. Oncol. 1999;72:60–65. © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-9098(199910)72:2<60::AID-JSO3>3.0.CO;2-1 |
| format | Article |
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Free cancer cells in the abdominal cavity exfoliated from a tumor are considered to be responsible for peritoneal dissemination, the most frequent pattern of failure in gastric carcinoma patients treated with curative surgery.
Methods
A prospective survival analysis was performed with 91 gastric carcinoma patients treated by potentially curative resection. Cytology was performed for all the patients. The method of Kaplan and Meier was used to construct curves with diagnosis of peritoneal dissemination and cancer death as the end points. Multivariate analysis by Cox's proportional hazards model was performed to identify independent prognostic factors of significance.
Results
Patients with a positive cytology result were confirmed to have a greater risk for recurrence in the pattern of peritoneal carcinomatosis and hence a significantly inferior prognosis. Positive cytology was the only significant independent prognostic factor among the curatively resected patients with advanced gastric carcinoma.
Conclusions
Peritoneal lavage cytology should be employed for all advanced cancer undergoing potentially curative resection for added accuracy in the stage classification. The results should also reflect the eligibility of the patients for future clinical trials involving perioperative intraperitoneal chemotherapy. J. Surg. Oncol. 1999;72:60–65. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/(SICI)1096-9098(199910)72:2<60::AID-JSO3>3.0.CO;2-1</identifier><identifier>PMID: 10518099</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Ascitic Fluid - cytology ; Humans ; Multivariate Analysis ; Neoplasm Staging ; peritoneal dissemination ; Peritoneal Lavage ; Peritoneal Neoplasms - pathology ; Prognosis ; Prospective Studies ; recurrence ; stage classification ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Survival Analysis</subject><ispartof>Journal of surgical oncology, 1999-10, Vol.72 (2), p.60-64</ispartof><rights>Copyright © 1999 Wiley‐Liss, Inc.</rights><rights>Copyright 1999 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3973-9bc4f6a28c4a133b7692cdaf02af467c0bfcf2c40204912a4c98667bc81031e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-9098%28199910%2972%3A2%3C60%3A%3AAID-JSO3%3E3.0.CO%3B2-1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-9098%28199910%2972%3A2%3C60%3A%3AAID-JSO3%3E3.0.CO%3B2-1$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10518099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kodera, Yasuhiro</creatorcontrib><creatorcontrib>Yamamura, Yoshitaka</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><creatorcontrib>Torii, Akihito</creatorcontrib><creatorcontrib>Hirai, Takashi</creatorcontrib><creatorcontrib>Yasui, Kenzo</creatorcontrib><creatorcontrib>Morimoto, Takeshi</creatorcontrib><creatorcontrib>Kato, Tomoyuki</creatorcontrib><title>Peritoneal washing cytology: Prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objectives
Free cancer cells in the abdominal cavity exfoliated from a tumor are considered to be responsible for peritoneal dissemination, the most frequent pattern of failure in gastric carcinoma patients treated with curative surgery.
Methods
A prospective survival analysis was performed with 91 gastric carcinoma patients treated by potentially curative resection. Cytology was performed for all the patients. The method of Kaplan and Meier was used to construct curves with diagnosis of peritoneal dissemination and cancer death as the end points. Multivariate analysis by Cox's proportional hazards model was performed to identify independent prognostic factors of significance.
Results
Patients with a positive cytology result were confirmed to have a greater risk for recurrence in the pattern of peritoneal carcinomatosis and hence a significantly inferior prognosis. Positive cytology was the only significant independent prognostic factor among the curatively resected patients with advanced gastric carcinoma.
Conclusions
Peritoneal lavage cytology should be employed for all advanced cancer undergoing potentially curative resection for added accuracy in the stage classification. The results should also reflect the eligibility of the patients for future clinical trials involving perioperative intraperitoneal chemotherapy. J. Surg. Oncol. 1999;72:60–65. © 1999 Wiley‐Liss, Inc.</description><subject>Ascitic Fluid - cytology</subject><subject>Humans</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>peritoneal dissemination</subject><subject>Peritoneal Lavage</subject><subject>Peritoneal Neoplasms - pathology</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>recurrence</subject><subject>stage classification</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Survival Analysis</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1v0zAUhiMEYmPwF5Cv0HaRcvwxJ-4Q0hRgK5ropPJ1d-S6TmeWxsV2Vvoz-Mck6zSQQFxZx3rP80rnybITCiMKwF4ezibV5IiCkrkCVR5SpRSFo4KN2SsJ4_Hp5E3-fjblr_kIRtX0hOX0QbZ_n3-Y7fcUlotCwV72JMZvAKCUFI-zPQrHtOyH_eznpQ0u-dbqhmx0vHLtkpht8o1fbsfkMvhl62NyhtzoprPE12Tto0vuxpLatYs-HolryVonZ9sUycalK7LUMYV-x-hgXOtXmnTtwoalH-i6J6Q-63TTbInpgr6lBRutSc63T7NHtW6ifXb3HmSf3r39WJ3nF9OzSXV6kRuuCp6ruRG11Kw0QlPO54VUzCx0DUzXQhYG5rWpmRHAQCjKtDCqlLKYm5ICp1bwg-zFjrsO_ntnY8KVi8Y2jW6t7yIWUHLBFe2Ds13QBB9jsDWug1vpsEUKOJhCHEzhcHkcLo87U1gwZCgBsTeFgynkCFhN-9-B-vyuvpuv7OIP5k7N79qNa-z2r87_V_6j8XbuqfmO6mKyP-6pOlyjLHhxjF8-nOFnJen510qg4L8A3MvAqQ</recordid><startdate>199910</startdate><enddate>199910</enddate><creator>Kodera, Yasuhiro</creator><creator>Yamamura, Yoshitaka</creator><creator>Shimizu, Yasuhiro</creator><creator>Torii, Akihito</creator><creator>Hirai, Takashi</creator><creator>Yasui, Kenzo</creator><creator>Morimoto, Takeshi</creator><creator>Kato, Tomoyuki</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199910</creationdate><title>Peritoneal washing cytology: Prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection</title><author>Kodera, Yasuhiro ; Yamamura, Yoshitaka ; Shimizu, Yasuhiro ; Torii, Akihito ; Hirai, Takashi ; Yasui, Kenzo ; Morimoto, Takeshi ; Kato, Tomoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3973-9bc4f6a28c4a133b7692cdaf02af467c0bfcf2c40204912a4c98667bc81031e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Ascitic Fluid - cytology</topic><topic>Humans</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>peritoneal dissemination</topic><topic>Peritoneal Lavage</topic><topic>Peritoneal Neoplasms - pathology</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>recurrence</topic><topic>stage classification</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kodera, Yasuhiro</creatorcontrib><creatorcontrib>Yamamura, Yoshitaka</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><creatorcontrib>Torii, Akihito</creatorcontrib><creatorcontrib>Hirai, Takashi</creatorcontrib><creatorcontrib>Yasui, Kenzo</creatorcontrib><creatorcontrib>Morimoto, Takeshi</creatorcontrib><creatorcontrib>Kato, Tomoyuki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kodera, Yasuhiro</au><au>Yamamura, Yoshitaka</au><au>Shimizu, Yasuhiro</au><au>Torii, Akihito</au><au>Hirai, Takashi</au><au>Yasui, Kenzo</au><au>Morimoto, Takeshi</au><au>Kato, Tomoyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peritoneal washing cytology: Prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>1999-10</date><risdate>1999</risdate><volume>72</volume><issue>2</issue><spage>60</spage><epage>64</epage><pages>60-64</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
Free cancer cells in the abdominal cavity exfoliated from a tumor are considered to be responsible for peritoneal dissemination, the most frequent pattern of failure in gastric carcinoma patients treated with curative surgery.
Methods
A prospective survival analysis was performed with 91 gastric carcinoma patients treated by potentially curative resection. Cytology was performed for all the patients. The method of Kaplan and Meier was used to construct curves with diagnosis of peritoneal dissemination and cancer death as the end points. Multivariate analysis by Cox's proportional hazards model was performed to identify independent prognostic factors of significance.
Results
Patients with a positive cytology result were confirmed to have a greater risk for recurrence in the pattern of peritoneal carcinomatosis and hence a significantly inferior prognosis. Positive cytology was the only significant independent prognostic factor among the curatively resected patients with advanced gastric carcinoma.
Conclusions
Peritoneal lavage cytology should be employed for all advanced cancer undergoing potentially curative resection for added accuracy in the stage classification. The results should also reflect the eligibility of the patients for future clinical trials involving perioperative intraperitoneal chemotherapy. J. Surg. Oncol. 1999;72:60–65. © 1999 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10518099</pmid><doi>10.1002/(SICI)1096-9098(199910)72:2<60::AID-JSO3>3.0.CO;2-1</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of surgical oncology, 1999-10, Vol.72 (2), p.60-64 |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Ascitic Fluid - cytology Humans Multivariate Analysis Neoplasm Staging peritoneal dissemination Peritoneal Lavage Peritoneal Neoplasms - pathology Prognosis Prospective Studies recurrence stage classification Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Survival Analysis |
| title | Peritoneal washing cytology: Prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection |
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