The Putative Morphogen, DIF-1, of Dictyostelium discoideum Activates Akt/PKB in Human Leukemia K562 Cells

The differentiation-inducing factor-1 (DIF-1) is a putative morphogen that induces stalk-cell formation in the lower eukaryote Dictyostelium discoideum. This molecule has been shown to inhibit cell growth and induce erythroid differentiation in human leukemia K562 cells. In the present study, to cla...

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Veröffentlicht in:	Biochemical and biophysical research communications 1999-10, Vol.263 (3), p.790-796
Hauptverfasser:	Kubohara, Yuzuru, Hosaka, Kohei
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Calcimycin - pharmacology Calcium Channel Blockers - pharmacology Cell Differentiation - drug effects Dictyostelium Dictyostelium discoideum Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Erythrocytes - cytology Gallic Acid - analogs & derivatives Gallic Acid - pharmacology Hexanones - chemistry Hexanones - pharmacology Humans K562 Cells Phosphorylation Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - drug effects Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Structure-Activity Relationship Thapsigargin - pharmacology
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